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List of works by Charles A. Dinarello

12

scientific article published in 2013

A 36-year-old woman with recurrent high-grade fevers, hypotension, and hypertriglyceridemia

scientific article published on January 2010

A Critical Role for STAT-3 Dependent Induction of Indoleamine 2, 3 Dioxygenase in Histone Deacetylase Inhibitors Mediated the Regulation of GVHD. ⬇️

scholarly article

A clinical perspective of IL‐1β as the gatekeeper of inflammation ⬇️

scientific article published on May 1, 2011

A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

scientific article

A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development

scientific article published on 3 November 2003

A guiding map for inflammation

scientific article published on July 2017

A new micromethod for determination of interleukin-1 production from frozen human blood mononuclear cells

scientific article

A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18.

scientific article

A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis

scientific article published on 01 January 2006

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist

scientific article (publication date: March 2014)

A primate model for the study of human fever

scientific article published on August 1, 1975

A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma

scientific article published on 13 March 2013

A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures.

scientific article published in September 2000

A signal for the caspase-1 inflammasome free of TLR

scientific article published on 01 April 2007

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits ⬇️

scientific article published on March 1, 1991

A surface amebic cysteine proteinase inactivates interleukin-18.

scientific article

A switch to high-flux helixone membranes reverses suppressed interferon-gamma production in patients on low-flux dialysis

scientific article

ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions

scientific article published on 12 February 2015

Ability of Human Leukocytic Pyrogen to Stimulate Brain Prostaglandin Synthesis In Vitro ⬇️

scientific article published on September 1, 1981

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

scientific article

Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways

scientific article published on 24 January 2008

Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells

scientific article published on February 2000

Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

scientific article published in 2022

Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance

scientific article published on 16 May 2016

Acute inflammation in gram-negative infection: endotoxin, interleukin 1, tumor necrosis factor, and neutrophils.

scientific article

Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion

scientific article published on 23 April 2014

Adenosine Reduces Cardiac TNF-α Production and Human Myocardial Injury Following Ischemia-Reperfusion ⬇️

scientific article published on May 1, 1998

Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen ⬇️

scientific article published on September 19, 1979

Adult-onset Still's disease with myocarditis successfully treated with the interleukin-1 receptor antagonist anakinra

scientific article published on 30 October 2010

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

scientific article

Alarmins: Feel the Stress.

scientific article published on February 2017

Allo-Antigen Expression on Both APCS and Tumor Is Required To Elicit an Effective GVL Response after Experimental Allogeneic BMT. ⬇️

scholarly article

Alpha 1 Anti-Trypsin (AAT) Offers Potent Therapy for Steroid Resistant Gut Gvhd: Interim Results of a Phase I/II Clinical Study ⬇️

scholarly article

Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

scientific article

Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans

scientific article published on 22 July 2020

Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury

scientific article published on 12 May 2011

Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

scientific article published on 14 July 2015

Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood

scientific article published on 05 February 2009

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation ⬇️

scientific article published on December 27, 2011

Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis.

scientific article published in August 2013

Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice

scientific article

Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits

scientific article published on July 1994

Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines

scientific article published on 17 December 2015

Alveolar type II cells inhibit fibroblast proliferation: role of IL-1alpha

scientific article published on 16 September 2005

An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor

scientific article published on 01 November 2005

An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism

scientific article

An antibody to a 17 amino acid synthetic peptide of the type I interleukin-1 receptor preferentially blocks interleukin-1 beta binding

scientific article published on December 1996

An overview on interleukin-1 as a therapeutic agent

scientific article published on January 1989

Anakinra Therapy for Non-cancer Inflammatory Diseases

Anakinra treatment in drug-resistant Behcet’s disease: a case series

Anti-cytokine strategies

scientific article published on January 1, 1992

Anti-cytokine therapeutics and infections

scientific article

Anti-inflammatory Agents: Present and Future

scientific article published on March 2010

Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase

scientific article published on 23 August 2013

Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution?

scientific article

Anti-interleukin-1 reactive cells in Hodgkin's disease

scientific article

Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein ⬇️

scientific article published on April 1, 1998

Antigen presentation by EBV-B cells to resting and activated T cells: role of interleukin 1.

scientific article

Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha

scholarly article

Atherogenic effects of chlamydia pneumoniae: refuting the innocent bystander hypothesis ⬇️

scientific article published on September 1, 2003

Author Correction: A guiding map for inflammation

scientific article published on 07 December 2020

Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo

scientific article published on 19 January 2016

Bacterial lipopolysaccharide induction of IL-6 in rat telencephalic cells is mediated in part by IL-1.

scientific article

Beneficial effects of IL-37 after spinal cord injury in mice

scientific article published on 19 January 2016

Biologic activities of interleukin-1 relevant to rheumatic diseases

scientific article published on January 1987

Biologic basis for interleukin-1 in disease

scientific article (publication date: 15 March 1996)

Biological consequences of monocyte activation during hemodialysis

scientific article published on January 1987

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons ⬇️

scientific article published on June 15, 1998

Biology of IL-38 and its role in disease

scientific article published in January 2018

Biology of interleukin 1.

scientific article published on February 1988

Biology of tumor necrosis factor-alpha- implications for psoriasis

scientific article published on April 2004

Blocking IL-1 in systemic inflammation

scientific article

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro ⬇️

scientific article published on November 1, 1991

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation

scientific article published on 13 December 2018

Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.

scientific article published on 09 September 2008

Blocking interleukin-1 in disease

scientific article

Blocking interleukin-1 receptors

scientific article published on January 1994

Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells

scientific article

Both inflammatory and endocrine mediators stimulate host responses to sepsis

scientific article published on February 1986

Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep

scientific article published on January 1986

Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans

scientific article published in April 2009

C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma

scientific article

CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells

scientific article published on 01 December 2005

Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis

scientific article published in December 2004

Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells

scientific article

Cell-Death Dependent Interleukin-1α Release Activates Host NLRP3 Inflammasome and Promotes Epithelial-Mesenchymal Transition in Metastatic Breast Cancer

scientific article published in 2022

Central effects of vasopressin and 1-desamino-8-D-arginine vasopressin (DDAVP) on interleukin-1 fever in the rat.

scientific article

Characteristics of pyrogen fevers are altered in the aged rabbit ⬇️

scientific article published on January 1, 1988

Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens

scientific article published on November 1989

Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood

scientific article published in October 1995

Chemotactic cytokines: the role of leukocytic pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis ⬇️

scientific article published on February 1, 1984

Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release

scientific article published on July 2004

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

scientific article published in 2021

Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice

scientific article published on February 1995

Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans

scientific article published on October 1, 1992

Circulating interleukin-38 concentrations in healthy adults

scientific article published in 2022

Circulating leptin during experimental endotoxemia in humans

scientific article published in May 1999

Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney

scientific article published on 30 March 2007

Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes

scientific article published on September 1984

Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression

scientific article published on September 2006

Clinical predictors of response to anakinra in patients with heart failure

scientific article published on 15 March 2014

Coagulation of whole blood stimulates interleukin-1 beta gene expression

scientific article published on July 1995

Colchicine therapy for familial mediterranean fever. A double-blind trial

scientific article

Colchicine therapy of familial Mediterranean fever

scientific article published on January 1, 1974

Combined anti-tumor necrosis factor-α therapy and DMARD therapy in rheumatoid arthritis patients reduces inflammatory gene expression in whole blood compared to DMARD therapy alone

scientific article (publication date: 2012)

Comment on "Power of Rare Diseases: Found in Translation"

Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation

scientific article published on 31 January 2013

Comparison of granulocyte-macrophage colony stimulating factor and interleukin-1 production from human peripheral blood mononuclear cells as measured by specific radioimmunoassays

scientific article published on July 1, 1992

Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro

scientific article published in March 1988

Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation

scientific article

Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta

scientific article

Controlling the production of interleukin-1 and tumor necrosis factor in disease

scientific article

Correction to: Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease

scholarly article published in Arthritis Research and Therapy

Correlation of serum levels of interleukin-1 family members with disease activity and response to treatment in hairy cell leukemia

scientific article published on March 1, 1998

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.

scientific article published in January 1990

Corrigendum: Anakinra Therapy for Non-cancer Inflammatory Diseases

scholarly article published in Frontiers in Pharmacology

Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

scientific article published on 11 January 2016

Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.

scientific article published in May 2009

Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells

scientific article published on January 1991

Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial

scientific article published on 7 March 2017

Cytokine accumulations in CSF of multiple sclerosis patients: frequent detection of interleukin-1 and tumor necrosis factor but not interleukin-6.

scientific article published in November 1990

Cytokine gene expression and synthesis by human megakaryocytic cells

scientific article published on March 1992

Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial

scientific article

Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line

scientific article published in November 1987

Cytokine-processing enzymes. Stopping the cuts

scientific article published on June 1995

Cytokines and biocompatibility

scientific article published on January 1990

Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species

scientific article

Cytokines as endogenous pyrogens

scientific article

Cytokines as potential therapeutic targets for inflammatory skin diseases

scientific article

Cytokines in Acute Myocardial Infarction

Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts

scientific article published on March 1995

Cytokines in human renal interstitial fibrosis. II. Intrinsic interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts

scientific article published on March 1995

Cytokines in the pathogenesis of fever

scientific article

Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia

scientific article

Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

scientific article published on 01 October 2003

Cytokines: agents provocateurs in hemodialysis?

scientific article

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

scientific article published on 08 April 2020

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

scientific article published on 28 May 2006

Deficient autophagy unravels the ROS paradox in chronic granulomatous disease

scientific article published on June 2014

Demonstration and characterization of two distinct human leukocytic pyrogens ⬇️

scientific article published on June 1, 1974

Demonstration of a bacterial structure in two human mediators: a sleep facilitating factor and a monokine

scientific article

Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans.

scientific article

Demonstration of circulating leukocytic pyrogen/interleukin-1 during fever

scientific article published in March 1984

Detection of circulating tumor necrosis factor after endotoxin administration.

scientific article

Detection of tumor necrosis factor soluble receptor p55 in blood samples from healthy and endotoxemic humans.

scientific article

Development of Anti-IL-1R3 Monoclonal Antibodies for Treating Cancer and IL-1 Family-Mediated Inflammation ⬇️

scholarly article

Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment.

scientific article

Differences in signaling pathways by IL-1beta and IL-18.

scholarly article

Differential effects of IL-1 alpha and IL-1 beta on tumorigenicity patterns and invasiveness

scientific article published on December 2003

Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells

scientific article published on July 2007

Differential effects of interleukin-1 alpha and interleukin-1 beta on human peripheral blood eosinophils

scientific article

Differential effects of platelets and platelet inhibition by ticagrelor on TLR2- and TLR4-mediated inflammatory responses

scientific article published on 26 February 2015

Differential gene expression for IL-1 receptor antagonist, IL-1, and TNF receptors and IL-1 and TNF synthesis may explain IL-1-induced resistance to infection.

scientific article

Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

scientific article

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

scientific article published on 22 December 2008

Differential role and tissue specificity of interleukin-1α gene expression in atherogenesis and lipid metabolism

article

Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I.

scientific article published on 11 October 2010

Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin, and acute-phase protein synthesis

scientific article published on February 1985

Dissociation of transcription from translation of human IL-1-beta: the induction of steady state mRNA by adherence or recombinant C5a in the absence of translation

scientific article published on January 1990

Does blocking cytokines in sepsis work?

scientific article published on 01 November 2002

Down modulation of IL-18 expression by human papillomavirus type 16 E6 oncogene via binding to IL-18.

scientific article

Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma

scientific article

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function

scholarly article

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

scientific article published on 22 July 2020

Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects

scientific article published on 26 June 2007

Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells

scientific article

Effect of indomethacin on increased resistance to bacterial infection and on febrile responses induced by muramyl dipeptide

scientific article published on November 1980

Effect of interleukin-18 on mouse core body temperature

scientific article published on March 2002

Effect of prophylactic colchicine therapy on leukocyte function in patients with familial Mediterranean fever

scientific article published on May 1, 1976

Effect of protein depletion and short-term parenteral refeeding on the host response to interleukin 1 administration

scientific article

Effect of recombinant α1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes

scientific article published on 20 May 2013

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

scientific article

Effects of leukocytic pyrogen (interleukin-1) on local cerebral glucose utilization in rats with and without premedication with indomethacin or dexamethasone

scientific article

Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease

scientific article published on 13 February 2019

Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia

scientific article published on February 1993

Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury.

scientific article

Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: Correlations with markers of inflammation and joint destruction ⬇️

scientific article published on June 1, 1998

Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease

scientific article published on 01 January 2005

Endogenous IL-32 controls cytokine and HIV-1 production

scientific article

Endogenous pyrogens.

scientific article

Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice

scientific article published on 11 January 2005

Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.

scientific article published in December 1992

Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure

scientific article (publication date: 2012)

Enhancement of growth of virulent strains of Escherichia coli by interleukin-1.

scientific article published in October 1991

Erratum: Corrigendum: IL-37 protects against obesity-induced inflammation and insulin resistance

scientific article published on 12 January 2015

Erratum: IL-1 family nomenclature

scholarly article by Charles A. Dinarello et al published March 2011 in Nature Immunology

Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease.

scientific article published on 29 November 2017

Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injury

scientific article published in November 2008

Evidence for two classes of cytokines that stimulate hepatic lipogenesis: relationships among tumor necrosis factor, interleukin-1 and interferon-alpha

scientific article published on July 1990

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

scientific article published on 17 October 2007

Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells

scientific article published on February 1993

Extracellular and nuclear roles of IL-37 after spinal cord injury

scientific article published on 28 September 2020

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8.

scientific article

Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality

scientific article published on 23 October 2008

Fever Produced in the Squirrel Monkey by Human Leukocytic Pyrogen ⬇️

scientific article published on April 1, 1979

Fever, interleukin-1 and host defense against malignancy

scientific article published on January 1, 1982

Fibroblast stimulation in schistosomiasis. V. Egg granuloma macrophages spontaneously secrete a fibroblast-stimulating factor.

scientific article published in June 1984

Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein

scientific article

Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain

scientific article

GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines

scientific article published on 01 January 2002

Generation and characterization of mice transgenic for human IL-18-binding protein isoform a

scientific article (publication date: November 2003)

Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood

scientific article published in January 1994

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

scientific article published on 16 November 2016

Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1.

scientific article published on August 1992

Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation

scientific article published on 11 December 2017

Grand Challenge in Inflammation ⬇️

scientific article published on February 14, 2012

Granulocyte-macrophage colony-stimulating factor synthesis during experimental endotoxemia in humans.

scientific article

Growth-promoting effect of recombinant interleukin 1 and tumor necrosis factor for a human astrocytoma cell line.

scientific article published in May 1987

High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein

scientific article published on 22 August 2009

High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis

scientific article published on 01 April 2004

Histone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer ⬇️

scientific article published on May 5, 2011

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.

scientific article published in February 2018

Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice

scientific article

Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans

scientific article

Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury

scientific article

Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

scholarly article

Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes

scientific article

Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir

scientific article

Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules

scientific article published on 9 May 2006

Histone hyperacetylation is associated with amelioration of experimental colitis in mice

scientific article published on 01 April 2006

Historical insights into cytokines

scientific article

Host and Environmental Factors Influencing Individual Human Cytokine Responses

scientific article published on November 2016

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells

scientific article

How interleukin-1β induces gouty arthritis

scientific article

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury

scientific article

Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis

scientific article published on 27 March 2015

Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice

scientific article published on 26 February 2018

Human leukocytic pyrogen induces release of specific granule contents from human neutrophils ⬇️

scientific article published on May 1, 1978

Human leukocytic pyrogen: purification and development of a radioimmunoassay ⬇️

scientific article published on October 1, 1977

Human myocardial tissue TNFalpha expression following acute global ischemia in vivo

scientific article published on September 1998

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease

scientific article published on 28 October 2020

Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation

scientific article published on May 2009

IL-1 Inhibition and Vascular Function in CKD.

scientific article published on 19 September 2016

IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation

scientific article published on 8 July 2015

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

scientific article

IL-1 family cytokines as drivers and inhibitors of trained immunity

scientific article published in 2022

IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

scientific article

IL-1 family nomenclature

scientific article

IL-1 induction-capacity of defined lipopolysaccharide partial structures.

scientific article published on May 1989

IL-1 is required for tumor invasiveness and angiogenesis ⬇️

scientific journal article

IL-1 production by T6 (CD1a) positive cord blood mononuclear cells (Langerhan's cell precursors?).

scientific article published on January 1989

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

scientific article published on 14 March 2016

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

scientific article published on 18 February 2014

IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia

scientific article published in January 2002

IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components

scientific article published on 01 July 2002

IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response

scientific article published on 24 August 2005

IL-18 activity in systemic lupus erythematosus

scientific article published on September 2009

IL-18 and infections: Is there a role for targeted therapies?

scientific article published on 13 August 2020

IL-18 binding protein reverses the life-threatening hyperinflammation of a baby with the NLRC4 mutation

scientific article published on 28 April 2017

IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction

scientific article published on 25 September 2009

IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease

scientific article

IL-18 in autoimmunity: review

scientific article

IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis

scientific article

IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease

scientific article (publication date: April 2002)

IL-1: discoveries, controversies and future directions

scientific article published on March 2010

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

scientific article published on 19 August 2019

IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation ⬇️

scientific article published on September 19, 2011

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

scientific article

IL-1β mediates leptin induction during inflammation ⬇️

scientific article published on January 1, 1998

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.

scientific article

IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor.

scientific article published in April 1988

IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease ⬇️

scientific article published on October 27, 2011

IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages

scientific article

IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis

scientific article published on 30 January 2017

IL-32 promotes angiogenesis

scientific article

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism

scientific article

IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease.

scientific article published on 14 August 2008

IL-32, a proinflammatory cytokine in rheumatoid arthritis ⬇️

scholarly article

IL-32-dependent effects of IL-1beta on endothelial cell functions

scholarly article

IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2

IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis.

scientific article

IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia.

scientific article published on 10 June 2017

IL-37 Expression Is Downregulated in Lesional Psoriasis Skin

scientific article published on 25 November 2020

IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake

scientific article published on 02 August 2018

IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8

scientific article published on 01 January 2021

IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis

scientific article (publication date: November 2014)

IL-37 is a fundamental inhibitor of innate immunity

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IL-37 protects against obesity-induced inflammation and insulin resistance

scientific article published on 3 September 2014

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

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IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells

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IL-37: a new anti-inflammatory cytokine of the IL-1 family.

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IL-38 Gene Deletion Worsens Murine Colitis

scientific article published in 2022

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

scientific article published on 6 February 2012

IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment

scientific article published on 30 October 2018

IL-6 and APPs: anti-inflammatory and immunosuppressive mediators ⬇️

scientific article published on September 1, 1997

IL‐38 prevents induction of trained immunity by inhibition of mTOR signaling

scientific article published in 2021

Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex

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Identification of amino acid residues critical for biological activity in human interleukin-18.

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Identification of the most active interleukin-32 isoform

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Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha

scientific article published on 17 May 2006

Immunological and inflammatory functions of the interleukin-1 family

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Immunoreactive interleukin-1 beta localization in the rat forebrain

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Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones

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Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain

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Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

scientific article published on 25 May 2021

Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease

scientific article published on 01 January 2008

Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes

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In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD

scientific article published on December 1, 1992

Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?

scientific article published on 01 June 2003

Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling

scientific article published on 10 July 2009

Increased plasma interleukin-1 activity in women after ovulation

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Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level

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Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254.

scientific article published in May 2011

Induction by toxic-shock-syndrome toxin-1 of a circulating tumor necrosis factor-like substance in rabbits and of immunoreactive tumor necrosis factor and interleukin-1 from human mononuclear cells

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Induction of interleukin-1 during CAPD.

scientific article published on January 1987

Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids

scientific article published in August 2005

Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed

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Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

scientific article published on 04 September 2020

Inflammasome activation and IL-1β and IL-18 processing during infection

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Inflammasome-independent regulation of IL-1-family cytokines

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Inflammation in human disease: anticytokine therapy

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Inflammation in rheumatology in 2015: New tools to tackle inflammatory arthritis

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Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta

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Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases ⬇️

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Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study

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Inflammatory markers and the risk of Alzheimer disease: the Framingham Study

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Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model ⬇️

scientific article published on September 6, 2011

Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans

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Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness

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Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

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Inhibitors of histone deacetylases as anti-inflammatory drugs.

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Inhibitory effects of elevated temperature on human cytokine production and natural killer activity

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Innate cytokines dictate the fate of acute intestinal inflammation

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Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

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Innate immune response of human alveolar macrophages during influenza A infection

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Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study

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Interferon alpha-2 enhances slow-wave sleep in rabbits

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Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis

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Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro

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Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process

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Interleukin 1 and myelin basic protein synergistically augment adoptive transfer activity of lymphocytes mediating experimental autoimmune encephalomyelitis in Lewis rats

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Interleukin 1 as mediator of the acute-phase response.

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Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

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Interleukin 1 receptors and biological responses

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Interleukin 1 reduces opioid binding in guinea pig brain

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Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle

scientific article published on May 1991

Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure.

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Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.

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Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection

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Interleukin 37 expression protects mice from colitis

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Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

scientific article published on 13 February 2017

Interleukin 4 (IL) 4 up-regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells

scientific article published on January 1, 1992

Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-alpha

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Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells ⬇️

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Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study.

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Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial

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Interleukin-1 Receptor Blockade Rescues Myocarditis-Associated End-Stage Heart Failure.

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Interleukin-1 activation and acute phase response during hemodialysis.

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Interleukin-1 alpha and interleukin-1 beta in preterm and term human parturition

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Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

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Interleukin-1 and dialysis

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Interleukin-1 and inhibition of interleukin-1 in hemodialysis patients

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Interleukin-1 and interleukin-1 antagonism ⬇️

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Interleukin-1 and interleukin-1 receptor antagonist production during haemodialysis: which cytokine is a surrogate marker for dialysis-related complications?

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Interleukin-1 and interleukin-1 receptor antagonist.

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Interleukin-1 and its biologically related cytokines

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Interleukin-1 and its receptor.

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Interleukin-1 and its relevance in patients treated with hemodialysis.

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Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

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Interleukin-1 and the Pathogenesis of the Acute-Phase Response ⬇️

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Interleukin-1 and the effects of cyclooxygenase inhibitors on its biological activities

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Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis

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Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases

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Interleukin-1 as a mediator of fatigue in disease: a narrative review

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Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain ⬇️

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Interleukin-1 beta in human plasma: optimization of blood collection, plasma extraction, and radioimmunoassay methods

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Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain

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Interleukin-1 blockade in rheumatoid arthritis and heart failure: a missed opportunity?

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Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).

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Interleukin-1 gene expression in rabbit vascular tissue in vivo.

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Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

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Interleukin-1 immunoreactive innervation of the human hypothalamus

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases ⬇️

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Interleukin-1 in the pathogenesis of and protection from inflammatory bowel disease

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Interleukin-1 in the pathogenesis of fever

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Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition

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Interleukin-1 induces natriuresis in conscious rats: role of renal prostaglandins

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Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits

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Interleukin-1 is a chemotactic factor for human T-lymphocytes

scientific article published in January 1987

Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone

scientific article published on 30 January 2004

Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease.

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Interleukin-1 receptor antagonist inhibits subcutaneous B16 melanoma growth in vivo.

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Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer

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Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells

scientific article published in May 1998

Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia

scientific article published in October 2003

Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases

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Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

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Interleukin-1 stimulates prostaglandin biosynthesis by human amnion

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Interleukin-1 stimulation in the ESRD patient: potential long-term consequences.

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Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist ⬇️

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Interleukin-1, anorexia, and dietary fatty acids

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Interleukin-1--its multiple biological effects and its association with hemodialysis

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Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative

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Interleukin-1.

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Interleukin-1.

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Interleukin-1.

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Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response

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Interleukin-10 enhances human immunodeficiency virus type 1 expression in a chronically infected promonocytic cell line (U1) by a tumor necrosis factor alpha-independent mechanism

scientific article published on June 1995

Interleukin-10 in patients with ST-segment elevation myocardial infarction

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Interleukin-18 and IL-18 binding protein

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Interleukin-18 and host defense against infection

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Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

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Interleukin-18 and the pathogenesis of inflammatory diseases

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Interleukin-18 and the treatment of rheumatoid arthritis

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Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium

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Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury

scientific article published on 27 August 2008

Interleukin-18 does not modulate the acute-phase response

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Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells

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Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma

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Interleukin-18 mediates interleukin-1-induced cardiac dysfunction

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Interleukin-18 treatment options for inflammatory diseases

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Interleukin-18, interleukin-18 binding protein and impaired production of interferon-gamma in chronic renal failure

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Interleukin-18, more than a Th1 cytokine

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Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice

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Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin).

scientific article published on January 1986

Interleukin-1beta

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Interleukin-1beta and the autoinflammatory diseases

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Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse

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Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

scientific article published in June 1998

Interleukin-1α as an intracellular alarmin in cancer biology

scientific article published on 01 August 2018

Interleukin-1β in innate inflammation, autophagy and immunity

scientific article published on 22 November 2013

Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: an open-label pilot study

scientific article published on 14 November 2011

Interleukin-1β–Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen–Induced Tumors

scientific article published on 01 February 2007

Interleukin-32 in chronic inflammatory conditions is associated with a higher risk of cardiovascular diseases

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Interleukin-32 induces the differentiation of monocytes into macrophage-like cells

scholarly article

Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA.

scientific article published on 28 January 2008

Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes

scientific article published on 2 March 2018

Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death ⬇️

scientific article published on 09 August 2012

Interleukin-32: a cytokine and inducer of TNFalpha

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Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis

scientific article published on 14 May 2011

Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir

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Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

scientific article published on 08 November 2019

Interleukin-37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome

scientific article published on 16 May 2019

Interleukin-37 monomer is the active form for reducing innate immunity

scientific article published on 28 February 2019

Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice

scientific article published on 23 February 2017

Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice

scientific article published on 30 January 2017

Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

scientific article published on 13 July 2018

Interleukin-37.

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Interleukin-38 in Health and Disease

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Interleukin-6 and tumor necrosis factor in cerebrospinal fluid: changes during pyrogen fever

scientific article published on May 1993

Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells

scientific article published on October 1991

Interplay between redox status and inflammasome activation ⬇️

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Intestinal production of interleukin-1 alpha during endotoxemia in the mouse.

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Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans ⬇️

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Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model

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Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide

scientific article published on June 1990

Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity

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Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus

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Is there a role for interleukin-1 blockade in intravenous immunoglobulin therapy?

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Is there an interleukin-1 genetic predisposition to developing severe sepsis?

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Isolation of an interleukin-1-like factor from human joint effusions

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Keep up the heat on IL-1 ⬇️

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Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice ⬇️

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Leptin deficiency enhances sensitivity to endotoxin-induced lethality.

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Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra

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Leukocyte endogenous mediator fails to alter protein dynamics in a model of liver dysfunction

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Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus

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Low-flux hemodialysis suppresses interferon-gamma production: the possible role of beta2-microglobulin.

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Lymphoblastoid B cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1.

scientific article published in January 1986

Lymphokines

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Lymphokines and bile secretion in the rat.

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Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

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MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: a Randomized Study

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MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo

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Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine ⬇️

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Maladie de Still de l’adulte avec myocardite traitée avec succès par anakinra, antagoniste du récepteur à l’interleukine-1

Measurement of immunoreactive interleukin-1 beta from human mononuclear cells: optimization of recovery, intrasubject consistency, and comparison with interleukin-1 alpha and tumor necrosis factor

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Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein

scientific article published on 01 February 2003

Mechanisms of loss of lean body mass in patients on chronic dialysis

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Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling

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Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses

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Modalities for reducing interleukin 1 activity in disease

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Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells

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Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade

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Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria

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More than inflammation: interleukin-1beta polymorphisms and the lipid metabolism

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Multiple cytokines stimulate hepatic lipid synthesis in vivo

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Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene

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Mutations in cryopyrin: bypassing roadblocks in the caspase 1 inflammasome for interleukin-1beta secretion and disease activity

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Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism

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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

scientific article published on 9 May 2017

NIH conference. Immunomodulators in clinical medicine

scientific article published on March 1987

NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome ⬇️

scientific article published on February 4, 2013

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

scientific article published on 03 August 2018

Neonatal interleukin-1 beta, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production

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Neuroinflammation in Alzheimer's disease

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Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction

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Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia

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Neutralization of IL-1α ameliorates Crohn's disease-like ileitis by functional alterations of the gut microbiome

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Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

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Neutrophil-mediated inhibition of proinflammatory cytokine responses

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New concepts on the pathogenesis of fever

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Nocardiosis in a child with chronic granulomatous disease ⬇️

scientific article published on July 1, 1973

Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways

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Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

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Normal free interleukin-18 (IL-18) plasma levels in dengue virus infection and the need to measure both total IL-18 and IL-18 binding protein levels

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Novel insights into the biology of interleukin-32 ⬇️

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Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911.

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OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis

scientific article published on 01 November 2019

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

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Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat.

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Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease

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Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity

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Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women

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Overview of interleukin-18: more than an interferon-γ inducing factor ⬇️

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Overview of the IL-1 family in innate inflammation and acquired immunity

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Overview of the interleukin-1 family of ligands and receptors

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Oxidation of low-density lipoproteins by acellular components of Chlamydia pneumoniae

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Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha

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P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.

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PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis

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PS21 - 102. IL-37 protects against obesity-induced inflammation and insulin resistance in mice

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PS4 - 4. Proteinase 3: a new link between inflammation, obesity and Type 2 Diabetes

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Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

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Paradoxical effects of constitutive human IL-32γ in transgenic mice during experimental colitis ⬇️

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Pathogenesis of Fever in Man ⬇️

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Pathogenesis of fever during hemodialysis

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Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

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Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept

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Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans

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Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from a polymeric guidance channel ⬇️

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Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat) ⬇️

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Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans

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Phorbol myristate acetate-protein complex mimics bioactivity of human IL-1. 1. Direct evidence that PMA temporarily enters and is released from cellular compartment during superinduction protocol

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Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.

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Plasma interleukin-1 activity in humans undergoing hemodialysis with regenerated cellulosic membranes

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Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease

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Plasmapheresis for fulminant meningococcemia

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Pre-treatment endogenous interleukin-1 receptor antagonist (IL-1Ra) levels in metastatic colorectal cancer (mCRC) patients are associated with clinical outcomes after anti-interleukin-1a therapy (MABp1)

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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

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Production of cytokines and cytokine inhibitory proteins in patients on dialysis.

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Production of cytokines by peripheral blood monocytes/macrophages infected with human immunodeficiency virus type 1 (HIV-1).

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Production of endogenous pyrogen

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Proinflammatory and Anti-inflammatory Cytokines as Mediators in the Pathogenesis of Septic Shock ⬇️

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Proinflammatory cytokines

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Proinflammatory cytokines in heart disease

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Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat.

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Prostaglandin formation in feline cerebral microvessels: effect of endotoxin and interleukin-1.

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Protection from RNA and DNA viruses by IL-32.

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Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein

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Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1.

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Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37.

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Proteinase 3 is an IL-32 binding protein

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Proteinase 3-processed form of the recombinant IL-32 separate domain

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Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury

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Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1.

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Purification and characterization of a unique human interleukin 1 from the tumor cell line U937.

scientific article published on May 1986

Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia

scientific article

Rapid responses to anakinra in patients with refractory adult-onset Still's disease

scientific article

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout

scientific article published on 29 February 2020

Rat interleukin-18 binding protein: cloning, expression, and characterization

scientific journal article

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

scientific article

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

scientific article published on 24 March 2013

Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition

scientific article

Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia

scientific article

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α ⬇️

scientific article published on 08 January 2011

Reduced concentrations of the B cell cytokine Interleukin 38 are associated with cardiovascular disease risk in overweight subjects

scientific article published on 30 October 2020

Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma

scientific article published on 06 March 2016

Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism

scientific article published on January 1, 1992

Regulation of Staphylococcus epidermidis-induced IFN-γ in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF

scientific article published on 01 January 2003

Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin

scientific article

Regulation of class III major histocompatibility complex gene products by interleukin-1.

scientific article

Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans

scientific article published on May 1986

Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis

scientific article

Resistant Behçet disease responsive to anakinra

scientific article published in August 2008

Response of Steroid-Refractory Acute GVHD to α1-Antitrypsin

scientific article

Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor

scholarly article

Review of Tissue-Protective Cytokines

article

Role for interleukin-1 in the pathogenesis of hypersensitivity diseases

scientific article

Role for nuclear interleukin-37 in the suppression of innate immunity

scientific article published on 21 February 2019

Role of IL-18 in second-hand smoke-induced emphysema

scientific article published on June 2013

Role of IL-1beta in type 2 diabetes

scientific article published on August 2010

Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1.

scientific article

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses.

scientific article published on 30 January 2014

Role of glutathione metabolism in host defense against Borrelia burgdorferi infection

scientific article published on 14 February 2018

Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits

scientific article

Role of interleukin-1 in infectious diseases

scientific article published on June 1, 1992

Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia

scientific article

Role of interleukin-18 in host defense against disseminated Candida albicans infection

scientific article

Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings

scientific article published on July 1, 1997

Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication.

scientific article

Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa: A Randomized Clinical Trial

scientific article

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis

scientific article published on 01 May 2011

Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes

scientific article published on November 2003

Self-regulation of procoagulant events on the endothelial cell surface

scientific article

Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus

scientific article published on 03 December 2010

Serum interleukin-1 (IL-1) activity in alcoholic hepatitis

scientific article

Setting the cytokine trap for autoimmunity

scientific article published on 01 January 2003

Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

scientific article published on 14 July 2005

Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice

scientific article published on 21 November 2019

Sleep-promoting effects of endogenous pyrogen (interleukin-1).

scientific article

Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha

scientific article published in September 2006

Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo

scientific article

Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation

scientific article published on March 1, 1998

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α

scientific article published on 5 December 2011

Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis

scientific article published on January 1, 1992

Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever

scientific article

Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen ⬇️

scientific article published on October 1, 1979

Studies on the ability of hemodialysis membranes to induce, bind, and clear human interleukin-1.

scientific article

Studies on the biological properties of purified and recombinant human interleukin-1.

scientific article published in February 1986

Studies on the molecular nature of human interleukin 1.

scientific article

Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta

scientific article published on 31 October 2009

Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

scientific article

Suppression of endotoxin-inducible cytokines in whole blood from human subjects following single dose of recombinant human interleukin-11

Suppression of inflammation and acquired immunity by IL-37.

scientific article

Suppression of innate inflammation and immunity by interleukin-37.

scientific article published on 09 April 2016

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases

scientific article published on 14 January 2015

Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock

scientific article

Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases

scientific article

Synthesis of tumor necrosis factor alpha and interleukin-1 receptor antagonist, but not interleukin-1, by human mononuclear cells is enhanced by exposure of whole blood to shear stress.

scientific article published in January 1996

Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.

scientific article published in June 1989

T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha

scientific article

TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization

scientific article published on 05 September 2018

TREM-1 interaction with the LPS/TLR4 receptor complex

scientific article published on 01 March 2011

Targeting innate immune mediators in type 1 and type 2 diabetes

scientific article published on 09 September 2019

Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease

scientific article published in February 2009

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

scientific article published in 2021

Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells

scientific article

Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB.

scientific article published on December 2004

The C3a receptor, caspase-1, and release of IL-1β.

scientific article published on November 2013

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice

scientific article

The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines

scientific article

The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses

scientific article

The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans

scientific article published on 19 November 2018

The Interleukin-1 Family

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

scientific article

The Jeremiah Metzger Lecture. The pathogenesis of fever in human subjects ⬇️

scientific article published on January 1, 1980

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease

scientific article published on 30 November 2020

The Pathogenic Th17 Cell Response to Major Schistosome Egg Antigen Is Sequentially Dependent on IL-23 and IL-1β ⬇️

scientific article published on October 14, 2011

The Production of Antibody against Human Leukocytic Pyrogen ⬇️

scientific article published on August 1, 1977

The Pyrogenicity of the Synthetic Adjuvant Muramyl Dipeptide and Two Structural Analogues ⬇️

scientific article published on December 1, 1978

The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering ⬇️

scientific article published on May 31, 2011

The Role of IL-1β in the Early Tumor Cell–Induced Angiogenic Response ⬇️

scientific article published on March 8, 2013

The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis

scientific article published on 05 July 2019

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

scientific article published in 2021

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

scientific article

The association of peripheral monocyte derived interleukin 1beta (IL-1beta), IL-1 receptor antagonist, and tumor necrosis factor-alpha with osteoarthritis in the elderly

scientific article published on September 1, 1998

The biological properties of interleukin-1.

scientific article published on November 1994

The biology of SAA: identification of the inducer, in vitro synthesis, and heterogeneity demonstrated with monoclonal antibodies

scientific article published on January 1982

The biology of interleukin 1 and comparison to tumor necrosis factor

scientific article

The biology of interleukin-1.

scientific article published in January 1992

The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma.

scientific article

The effect of interleukin 1 on IgG synthesis in systemic lupus erythematosus

scientific article published in December 1987

The effect of whole body hyperthermia on the immune cell activity of cancer patients

scientific article

The endogenous pyrogens in host-defense interactions

scientific article

The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro

scientific article published on May 2010

The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo

scientific article

The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients

scientific article

The history of fever, leukocytic pyrogen and interleukin-1

scientific article published on January 2015

The in vivo and in vitro effects of interleukin-1 and tumor necrosis factor on murine cytomegalovirus infection

scientific article

The induction of interleukin-1 in humans and its metabolic effects

scientific article published on August 1985

The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice.

scientific article published on April 1996

The influence of lipoxygenase inhibitors on the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (interleukin-1).

scientific article

The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression

scientific article published on June 2007

The interleukin 1 receptor

scientific article published on February 1989

The interleukin-1 family: 10 years of discovery

scientific article (publication date: December 1994)

The interleukin-1 family: back to the future

scientific article

The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

scientific article published in November 2012

The many worlds of reducing interleukin-1

scientific article published on 01 July 2005

The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro

scientific article

The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment

scientific article published in August 2001

The paradox of pro-inflammatory cytokines in cancer

scientific article

The pathophysiology of the pro-inflammatory cytokines

scientific article published on January 1990

The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription

scholarly article

The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome

scientific article published on June 1991

The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures

scientific article published on 11 March 2002

The role of interleukin 1 (IL 1) in tumor-NK cell interactions: correction of defective NK cell activity in cancer patients by treating target cells with IL 1.

scientific article published in October 1985

The role of interleukin-1 in disease

scientific article

The role of interleukin-1 in host responses to infectious diseases

scientific article published on October 1, 1992

The role of interleukin-32 against tuberculosis

scientific article published on 2 July 2015

The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis

scientific article published on 14 September 2009

The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity.

scientific article published on September 1990

The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1.

scientific article

The role of the liver in the production of fever and in pyrogenic tolerance

scientific article published on January 1968

The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6

scientific article published on 21 September 2018

The specific IL-1 inhibitor from the human M20 cell line is distinct from the IL-1 receptor antagonist

scientific article published on December 1, 1991

The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

scientific article

Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis ⬇️

scientific article published on December 1, 2001

Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation

scientific article published in August 2004

Thermoregulation and the pathogenesis of fever

scientific article published on June 1996

Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation

scientific article published on June 1996

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

scientific article published on 12 May 2016

Towards a role of interleukin-32 in atherosclerosis ⬇️

scientific article published on May 30, 2013

Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement

scientific article published in January 1990

Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor ⬇️

scientific article published on February 1, 1991

Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis

scientific article

Treating Life-Threatening Myocarditis by Blocking Interleukin-1.

scientific article

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

scientific article published on 26 August 2016

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

scientific article published on 01 December 2017

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases ⬇️

scientific article published on August 1, 2012

Treating inflammation by blocking interleukin-1 in humans

scientific article

Treating pulmonary silicosis by blocking interleukin 1

scientific article published on 01 March 2015

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

scientific article (publication date: December 2015)

Treatment of Dilated Cardiomyopathy With Interleukin-1 Inhibition

scientific article published on 31 July 2018

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

scientific article published in January 2018

Treatment of Inflammatory Diseases with IL-1 Blockade

scientific article published on 07 March 2018

Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors

scientific article

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

scientific article published in 2021

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines

scientific article published on April 1988

Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings

scientific article

Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function

scientific article published in July 1999

Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils

scientific article

Tumor necrosis factor-alpha, interleukin-1, and interferon alpha stimulate triglyceride synthesis in HepG2 cells

scientific article published on September 1991

Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade ⬇️

scholarly article by B. Heinhuis et al published April 2011 in Annals of the Rheumatic Diseases

Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture

scientific article

Ultrafiltration to remove endotoxins and other cytokine-inducing materials from tissue culture media and parenteral fluids.

scientific article

Understanding human immune function using the resources from the Human Functional Genomics Project

scientific article published on August 2016

Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation

scientific article published in March 2004

Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway

scientific article published on 8 May 2017

Ventricular fluid interleukin-1 activity in patients with head injury

scientific article

Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial

scientific article

Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT.

scientific article published on 7 August 2017

Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels

scientific article published on 18 January 2007

Why not treat human cancer with interleukin-1 blockade?

scientific article

alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice

scholarly article

α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics

scientific article

α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils

scientific article published on 13 July 2016

α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression.

scientific article published on 11 September 2015

α1-Antitrypsin Infusion for treatment of Steroid Resistant Acute Graft-versus-Host Disease

scientific article published on 2 February 2018

α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes

scientific article

β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo

scientific article

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