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List of works by J G Coen van Hasselt

A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.

scientific article published on 7 November 2017

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

scientific article published on 18 November 2016

Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans.

scientific article published on 13 May 2009

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors

scientific article published on 01 July 2019

Clinical Pharmacokinetics of Amikacin in Pediatric Patients: A Comprehensive Review of Population Pharmacokinetic Analyses.

scientific article

Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis

scientific article published on 15 January 2025

Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".

scientific article published on 30 March 2015

Crowdsourced Asparagus Urinary Odor Population Kinetics.

scientific article published on 14 December 2017

Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.

scientific article published on 30 August 2014

Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error

scientific article published on 02 May 2014

Development of a framework for cohort simulation in cost-effectiveness analyses using a multistep ordinary differential equation solver algorithm in R.

scientific article published on 20 March 2013

Disease Progression/Clinical Outcome Model for Castration-Resistant Prostate Cancer in Patients Treated With Eribulin

scientific article

Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

scientific article published on 03 May 2019

Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study.

scientific article

Evaluating renal function and age as predictors of amikacin clearance in neonates: model-based analysis and optimal dosing strategies.

scientific article published on 20 May 2016

Evidence-based drug treatment for special patient populations through model-based approaches.

scientific article published on 11 May 2017

Host-response biomarkers for the diagnosis of bacterial respiratory tract infections

scientific article published on 01 March 2019

Integrated Simulation Framework for Toxicity, Dose Intensity, Disease Progression, and Cost Effectiveness for Castration-Resistant Prostate Cancer Treatment With Eribulin

scientific article

Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

scientific article published on May 2015

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine

scientific article

Leveraging physiological data from literature into a pharmacokinetic model to support informative clinical study design in pregnant women.

scientific article

Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures.

scientific article

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

scientific article published on 8 September 2017

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

scientific article

Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab

scientific article published on 21 August 2012

Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations

scientific article published in 2022

Novel Δ(9) -tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects.

scientific article

Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel

scientific article published on 8 April 2014

Optimizing drug development of anti‐cancer drugs in children using modelling and simulation ⬇️

scientific article published on July 1, 2013

Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens

scientific article published on 10 February 2018

Pharmacokinetic-pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects.

scientific article published on June 2011

Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach.

scientific article published in October 2012

Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

scientific article published on 06 February 2016

Population Pharmacokinetic-Pharmacodynamic Analysis of Trastuzumab-Associated Cardiotoxicity

scientific article published on June 1, 2011

Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass to optimize dosing regimens for children undergoing cardiac surgery.

scientific article published on 20 December 2016

Population pharmacokinetics of lamotrigine in Indian epileptic patients.

scientific article

Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects.

scientific article published on 17 May 2017

Population pharmacokinetic–pharmacodynamic analysis for eribulin mesilate‐associated neutropenia ⬇️

scientific article published on September 1, 2013

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model

scientific article published on 11 September 2017

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

scientific article

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

scientific article published on 10 May 2016

Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction

scientific article published on 10 July 2018

Real world cost of human epidermal receptor 2-positive metastatic breast cancer patients: a longitudinal incidence-based observational costing study in the Netherlands and Belgium.

scientific article published on 21 November 2014

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care

scientific article published on 4 January 2016

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy

scientific article published on 3 February 2014

Severe cannabinoid intoxication in a patient with non-small-cell lung cancer

scientific article published on 01 January 2012

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

scientific article published on 09 April 2013

Special issue: mathematical pharmacology.

scientific article

Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid.

scientific article published on December 2015

Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits Δ9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans

scientific article

Systems Pharmacology: Defining the Interactions of Drug Combinations

scientific article published on 27 September 2018

The impact of structural uncertainty on cost-effectiveness models for adjuvant endocrine breast cancer treatments: the need for disease-specific model standardization and improved guidance

scientific article published on January 2014

Time-dependent resource use and costs associated with different states of disease in patients diagnosed with HER-2-positive metastatic breast cancer ⬇️

scientific article published on May 5, 2013

Towards integrative systems pharmacology models in oncology drug development.

scientific article published on 16 July 2015

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

scientific article

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

scientific article published on 23 September 2020

Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans.

scientific article published on 8 January 2018

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