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List of works by Kwok Ho Lam

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

scientific article

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

scientific article published in Nature Communications

Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery.

scientific article published on 15 April 2015

Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component

scientific article published on 12 February 2014

Crystal Structure of Activated CheY1 from Helicobacter pylori

scientific article

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

scientific article published on 08 March 2017

Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease

scientific article

Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin.

scientific article published on 19 February 2015

High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex

scientific article

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

scientific article

Massively parallel de novo protein design for targeted therapeutics.

scientific article published on 27 September 2017

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

scientific article published on 13 June 2016

Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies

scientific article published on 06 January 2022

Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.

scientific article published on 23 April 2018

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.

scientific article

Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.

scientific article

Structure of the full-length Clostridium difficile toxin B

scientific article published on 15 July 2019

Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins.

scientific article published in February 2018

The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.

scientific article published on 14 October 2017

Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in Helicobacter pylori

scientific article published on 10 July 2018

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