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List of works by M C Valadares

4-Fluorobenzaldehyde limonene-based thiosemicarbazone induces apoptosis in PC-3 human prostate cancer cells.

scientific article published on 16 April 2018

4-Nerolidylcatechol analogues as promising anticancer agents

scientific article published on 19 August 2015

4-Nerolidylcatechol and its synthetic analogues: antioxidant activity and toxicity evaluation.

scientific article published on 20 December 2012

4-Nerolidylcatechol: apoptosis by mitochondrial mechanisms with reduction in cyclin D1 at G0/G1 stage of the chronic myelogenous K562 cell line

scientific article

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis.

scientific article published on 08 December 2015

A novel chalcone derivative, LQFM064, induces breast cancer cells death via p53, p21, KIT and PDGFRA.

scientific article published on 13 June 2017

Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone.

scientific article published on 20 August 2017

Antifungal potential of punicalagin against Cryptococcus neoformans species complex

scientific article published on 22 October 2018

Antinociceptive and Anti-Inflammatory Activities of the Ethanolic Extract fromSynadenium umbellatumPax. (Euphorbiaceae) Leaves and Its Fractions ⬇️

scientific article published on January 21, 2013

Antinociceptive and antiinflammatory activities of grandisin extracted from Virola surinamensis

scientific article published on 01 January 2010

Antiproliferative Activity and VEGF Expression Reduction in MCF7 and PC-3 Cancer Cells by Paclitaxel and Imatinib Co-encapsulation in Folate-Targeted Liposomes.

scientific article

Application of the adverse outcome pathway (AOP) framework for investigating skin sensitization potential of nanomaterials using new approach methods

scientific article published on 19 July 2020

Ascorbic acid encapsulated into negatively charged liposomes exhibits increased skin permeation, retention and enhances collagen synthesis by fibroblasts

scientific article published in Scientific Reports

Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalis L.), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale R.) Essential Oils in Cervical Cancer Cells (HeLa).

scientific article published on 30 November 2016

Bioconversion of quercetin and rutin and the cytotoxicity activities of the transformed products.

scientific article

Biodegradable nanoparticles designed for drug delivery: The number of nanoparticles impacts on cytotoxicity.

scientific article published on 13 January 2015

Brazil Moves Toward the Replacement of Animal Experimentation

scientific article published on 01 May 2019

Campomanesia adamantium (Myrtaceae) fruits protect HEPG2 cells against carbon tetrachloride-induced toxicity.

scientific article published on 16 December 2014

Carbendazim induces death in alveolar epithelial cells: A comparison between submerged and at the air-liquid interface cell culture

scientific article published on 06 March 2019

Chemopreventive effects of FITOPROT against 5-fluorouracil-induced toxicity in HaCaT cells.

scientific article published on 26 September 2017

Chemoprotective effect of the tetrahydrofuran lignan grandisin in the in-vivo rodent micronucleus assay.

scientific article published on March 2011

Corneal histomorphometric analysis: The depth of damage induced in the bovine cornea correlates with the severity of the ocular toxicity

scientific article published on 04 July 2019

Cytotoxicity and antiangiogenic activity of grandisin.

scientific article published in December 2009

Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release.

scientific article

Differential infiltration of CD8+and NK cells in lip and oral cavity squamous cell carcinoma

scientific article published on 14 September 2009

Diuretic activity and acute oral toxicity of Palicourea coriacea (Cham.) K Schum.

scientific article

Ecotoxicological assessment of glyphosate-based herbicides: Effects on different organisms

scientific article published on 12 August 2016

Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients.

scientific article published on 30 March 2015

Effect of photobiomodulation on the severity of oral mucositis and molecular changes in head and neck cancer patients undergoing radiotherapy: a study protocol for a cost-effectiveness randomized clinical trial

scientific article published on 01 February 2019

Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clini

scientific article published on 29 June 2017

Effects of hair dye ingredients on the oxidative stress response: Modulation of the mRNA expressions of NRF2, HO-1, and FOS in HaCaT keratinocytes

scientific article published on 22 January 2020

Electrochemical remediation of amoxicillin: detoxification and reduction of antimicrobial activity

scientific article published on 18 June 2018

Eugenia dysenterica DC. (Myrtaceae) exerts chemopreventive effects against hexavalent chromium-induced damage in vitro and in vivo.

scientific article published on 30 May 2016

Evaluation of Caesalpinia ferrea extract on bone marrow hematopoiesis in the murine models of listeriosis and Ehrlich ascites tumor ⬇️

scientific article published on 01 August 2001

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: The case of henna-based hair-colouring products containing p-phenylenediamine

scientific article published on 20 June 2019

Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats

scientific article published on 24 April 2019

Identification of crotamine in the venom of Crotalus durissus collilineatus by three different methods

scientific article published on 30 December 2014

Impact of ultrasound-assisted extraction on quality and photostability of the Pothomorphe umbellata extracts

scientific article published in September 2011

In vitro assessment of skin sensitization, photosensitization and phototoxicity potential of commercial glyphosate-containing formulations.

scientific article published on 4 April 2017

In vitro safety and efficacy evaluations of a complex botanical mixture of Eugenia dysenterica DC. (Myrtaceae): Prospects for developing a new dermocosmetic product

scientific article published on 4 April 2017

Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma

scientific article published on 01 July 2019

Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor - LQFM030.

scientific article published on 28 June 2016

Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity

scientific article published in November 2018

Investigation of Ehrlich ascites tumor cell death mechanisms induced by Synadenium umbellatum Pax.

scientific article published on 29 April 2011

Involvement of the monoamine system in antidepressant-like properties of 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester

scientific article published on 10 November 2015

In vitro genotoxicity and in vivo subchronic evaluation of the anti-inflammatory pyrazole compound LQFM021.

scientific article published on 7 September 2017

LQFM030 reduced Ehrlich ascites tumor cell proliferation and VEGF levels.

scientific article

Liposomal Entrapment of 4-Nerolidylcatechol: Impact on Phospholipid Dynamics, Drug Stability and Bioactivity.

scientific article published on January 2015

Mechanistic-based non-animal assessment of eye toxicity: Inflammatory profile of human keratinocytes cells after exposure to eye damage/irritant agents

scientific article published on 25 June 2018

Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositis induced by 5-fluorouracil in hamsters

scientific article published on 23 January 2019

Mucoadhesive formulation of Bidens pilosa L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice

scientific article published on 23 March 2015

Mucopenetrating lipoplexes modified with PEG and hyaluronic acid for CD44-targeted local siRNA delivery to the lungs

scientific article published on 29 July 2019

Multicompartimental nanoparticles for co-encapsulation and multimodal drug delivery to tumor cells and neovasculature

scientific article published on 30 October 2013

New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities.

scientific article published on 16 August 2016

Pharmacological evaluation and molecular docking of new di-tert-butylphenol compound, LQFM-091, a new dual 5-LOX/COX inhibitor

scientific article published on 06 June 2017

Photoprotective effect and acute oral systemic toxicity evaluation of the novel heterocyclic compound LQFM048.

scientific article published on 2 April 2016

Polymorphonuclear Phagocytosis and Killing in Workers Occupationally Exposed to Hexachlorobenzene ⬇️

scientific article published on 01 August 1998

Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells

scientific article published on 04 August 2019

Radical Scavenger Capacity of Jabuticaba Fruit (Myrciaria cauliflora) and Its Biological Effects in Hypertensive Rats.

scientific article published on 20 December 2017

Randomized clinical trial of a mucoadhesive formulation containing curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae) extract (FITOPROT) for prevention and treatment of oral mucositis - phase I study

scientific article published in August 2018

Short Time Exposure (STE) test in conjunction with Bovine Corneal Opacity and Permeability (BCOP) assay including histopathology to evaluate correspondence with the Globally Harmonized System (GHS) eye irritation classification of textile dyes

scientific article published on 27 May 2015

Small-molecule MDM2 inhibitor LQFM030-induced apoptosis in p53-null K562 chronic myeloid leukemia cells

scientific article published on 03 February 2020

Synthesis, Docking Studies, Pharmacological Activity and Toxicity of a Novel Pyrazole Derivative (LQFM 021)—Possible Effects on Phosphodiesterase ⬇️

scientific article published on January 1, 2013

The 21st Century movement within the area of skin sensitization assessment: From the animal context towards current human-relevant in vitro solutions

scientific article published on 17 August 2019

The Effect of Photobiomodulation on Nitrite and Inflammatory Activity in Radiotherapy-Induced Oral Mucositis: A Randomized Clinical Trial

scientific article published on 30 September 2020

The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.

scientific article published on 23 March 2018

Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers

scientific article published on 13 July 2017

Toxicity evaluation of the photoprotective compound LQFM048: Eye irritation, skin toxicity and genotoxic endpoints.

scientific article published on 26 April 2016

Toxico-pharmacological evaluations of the small-molecule LQFM166: Inducer of apoptosis and MDM2 antagonist

article

Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma

scientific article published on 22 October 2012

Zidovudine Glycosylation by Filamentous Fungi Leads to Better Redox Stability and Improved Cytotoxicity on B16F10 Murine Melanoma Cells

scientific article published on 24 April 2020

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