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List of works by Xue-Ru Wu

A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.

scientific article

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability

scientific article published on 22 February 2019

Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells.

scientific article

Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis

scientific article published on 18 June 2018

Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection

scientific article

Attention to Detail by Single-cell Sequencing.

scientific article published on 12 September 2016

Bladder cancers arise from distinct urothelial sub-populations.

scientific article

Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice

scientific article

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.

scientific article published on 28 September 2015

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

scientific article published on 01 October 2019

Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice ⬇️

scientific article published on November 10, 2010

Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

scientific article

Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.

scientific article published on 30 May 2013

DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells

scientific article published in 2022

Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor.

scientific article published on 13 March 2013

Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis.

scientific article published on December 2009

Distinct Glycan Structures of Uroplakins Ia and Ib

scientific article published in Journal of Biological Chemistry

Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

scientific article published on 01 December 2019

Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli

scientific article

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells.

scientific article

E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity

scientific article

Early detection and measurement of urothelial tumors in mice.

scientific article

Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis

scientific article

Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice

scientific article published on 07 October 2019

Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo

scientific article

FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma

scientific article published on 9 May 2016

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum

scientific article published on 26 February 2016

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

scientific article published on 21 October 2019

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

scientific article published on 14 May 2015

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).

scientific article published on 15 April 2016

Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin.

scientific article published on 05 April 2017

Interstitial calcinosis in renal papillae of genetically engineered mouse models: relation to Randall's plaques

scientific article

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.

scientific article published on 18 April 2011

Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.

scientific article published on 11 October 2013

Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer

scientific article published on May 2015

Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration.

scientific article

Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation.

scientific article

Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

scientific article published in Scientific Reports

Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes ⬇️

scientific article published on 02 October 2019

Molecular and Cellular Effects of Tamm-Horsfall Protein Mutations and Their Rescue by Chemical Chaperones ⬇️

scientific article published on November 22, 2011

Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment.

scientific article published on 22 September 2010

On a FOX hunt: functions of FOX transcriptional regulators in bladder cancer.

scientific article published on 29 November 2016

Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas

scientific article published on 20 March 2015

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

scientific article published on 21 June 2018

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

scientific article published on 16 November 2017

Progress made in the use of animal models for the study of high-risk, nonmuscle invasive bladder cancer

scientific article

Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein

scientific article

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis ⬇️

scientific article

Renal tubule-specific expression and urinary secretion of human growth hormone: a kidney-based transgenic bioreactor growth

scientific article published on 01 April 2003

RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.

scientific article published on 5 March 2012

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

scientific article published on 16 March 2016

SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells

scientific journal article

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

scientific article published on 23 March 2016

TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma

scientific article published on 15 September 2015

Tamm-Horsfall Protein Regulates Circulating and Renal Cytokines by Affecting Glomerular Filtration Rate and Acting as a Urinary Cytokine Trap ⬇️

scientific article published on March 27, 2012

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

scientific article published on 2 January 2015

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

scientific article published on 27 November 2017

Tamm-Horsfall Protein/Uromodulin Deficiency Elicits Tubular Compensatory Responses Leading to Hypertension and Hyperuricemia.

scientific article published on 10 January 2018

Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury

scientific article published on 6 February 2013

Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.

scientific article published on 12 January 2011

Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo

scientific article published on 17 November 2015

Temporally and spatially controllable gene expression and knockout in mouse urothelium.

scientific article

The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

scientific article

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

scientific article published on 12 July 2013

The Epithelium—Molecular Landscaping for an Interactive Barrier ⬇️

scientific article published on January 1, 2010

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells

scientific article published on 28 February 2019

Tumorigenicity of RTK/RAS in urothelium

scientific article published on 10 August 2015

Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis

scientific article published on 01 January 2020

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.

scientific article

Uromodulin in kidney injury: an instigator, bystander, or protector?

scientific article published on 23 January 2012

Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)

scientific article published on 23 August 2018

Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells.

scientific article published on 22 July 2017

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

scientific article

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