List of works - Fulvio Saccoccia

Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target

scientific article

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.

scientific article published on 6 October 2017

Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy

scientific article published on 12 October 2020

Evolution of the p53-MDM2 pathway.

scientific article

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

scientific article published on 27 December 2018

Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography

scientific article

Moonlighting by Different Stressors: Crystal Structure of the Chaperone Species of a 2-Cys Peroxiredoxin

scientific article

On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases

scientific article

One ring (or two) to hold them all – on the structure and function of protein nanotubes.

scientific article published on 23 June 2015

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

scientific article published on 12 November 2019

Selenocysteine robustness versus cysteine versatility: a hypothesis on the evolution of the moonlighting behaviour of peroxiredoxins.

scientific article

Switching between the alternative structures and functions of a 2-Cys peroxiredoxin, by site-directed mutagenesis

scientific article

The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures

scientific article

Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability

scientific article published on 27 November 2019

Thioredoxin reductase and its inhibitors.

scientific article published on January 2014

Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target.

scientific article published on 18 March 2016

List of works by Fulvio Saccoccia

Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.

Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy

Evolution of the p53-MDM2 pathway.

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography

Moonlighting by Different Stressors: Crystal Structure of the Chaperone Species of a 2-Cys Peroxiredoxin

On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases

One ring (or two) to hold them all – on the structure and function of protein nanotubes.

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

Selenocysteine robustness versus cysteine versatility: a hypothesis on the evolution of the moonlighting behaviour of peroxiredoxins.

Switching between the alternative structures and functions of a 2-Cys peroxiredoxin, by site-directed mutagenesis

The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures

Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability

Thioredoxin reductase and its inhibitors.

Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target.