List of works - Jianxin Dai

A bispecific antibody effectively neutralizes all four serotypes of dengue virus by simultaneous blocking virus attachment and fusion

scientific article published on 23 February 2016

A chimeric SM5-1 antibody inhibits hepatocellular carcinoma cell growth and induces caspase-dependent apoptosis

scientific article published on 23 October 2007

A functional motif QLYxxYP is essential for osteopontin induced T lymphocyte activation and migration

scientific article published on 29 January 2009

A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo

scientific article

A humanized anti-osteopontin antibody protects from Concanavalin A induced-liver injury in mice ⬇️

scientific article published on February 25, 2011

A novel functional motif of osteopontin for human lymphocyte migration and survival

scientific article published on 15 July 2008

Acid-induced aggregation propensity of nivolumab is dependent on the Fc.

scientific article published on 16 June 2016

Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis.

scientific article

Antibody-targeted immunoliposomes for cancer treatment

scientific article published on December 2013

Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance

article

CD20 Antibody-Conjugated Immunoliposomes for Targeted Chemotherapy of Melanoma Cancer Initiating Cells

scientific article published on November 2015

Cancer immunotherapy using in vitro genetically modified targeted dendritic cells

scientific article

Characterization of alanine to valine sequence variants in the Fc region of nivolumab biosimilar produced in Chinese hamster ovary cells

scientific article published on 6 April 2016

Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles ⬇️

scientific article published on April 28, 2012

Combating non-Hodgkin lymphoma by targeting both CD20 and HLA-DR through CD20-243 CrossMab

scientific article

Combination of dextran sulfate and recombinant trypsin on aggregation of Chinese hamster ovary cells

scientific article

Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody

scientific article published on 17 April 2007

Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions

scientific article published on 01 December 2005

Development of SM5-1-conjugated ultrasmall superparamagnetic iron oxide nanoparticles for hepatoma detection

scientific article

Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity

scientific article

Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis.

scientific article published on 7 May 2008

Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU.

scientific article

Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP.

scientific article published on 31 October 2013

Expression, purification, and characterization of an immunotoxin containing a humanized anti-CD25 single-chain fragment variable antibody fused to a modified truncated Pseudomonas exotoxin A.

scientific article published on 19 September 2007

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

scientific article

Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab

scientific article

Functional and stable expression of recombinant human FOXP3 in bacterial cells and development of antigen-specific monoclonal antibodies

scientific article published on 30 August 2007

Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency

scientific article

Genetically targeted T cells eradicate established breast cancer in syngeneic mice

scientific article

In-Depth Characterization of a Pro-Antibody-Drug Conjugate by LC-MS.

scientific article published on 5 July 2016

Increased expression of iASPP, regulated by hepatitis B virus X protein-mediated NF-κB activation, in hepatocellular carcinoma

scientific article

Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA.

scientific article published on 20 September 2013

Lysosome-dependent necrosis specifically evoked in cancer cells by gold nanorods

scientific article published on 8 May 2017

Molecular Basis of Recognition of Human Osteopontin by 23C3, a Potential Therapeutic Antibody for Treatment of Rheumatoid Arthritis

scientific article

Nano polymeric carrier fabrication technologies for advanced antitumor therapy

scientific article

Novel Dual-Control Poly( N -Isopropylacrylamide- Co -Chlorophyllin) Nanogels for Improving Drug Release ⬇️

scientific article published on March 1, 2012

PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumor progression with reduced toxicity and immunogenicity

scientific article

Phase I trial of a humanized, Fc receptor nonbinding anti-CD3 antibody, hu12F6mu in patients receiving renal allografts

scientific article

Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma

scientific article published on 31 May 2013

Potent Neutralization of Botulinum Neurotoxin/B by Synergistic Action of Antibodies Recognizing Protein and Ganglioside Receptor Binding Domain ⬇️

scientific article published on August 29, 2012

Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy

scientific article published on 13 January 2016

Preparation and Characterization of Paclitaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody

scientific article

Preparation and characterization of recombinant protein ScFv(CD11c)-TRP2 for tumor therapy from inclusion bodies in Escherichia coli

scientific article

Regulation of cell growth and apoptosis through lactate dehydrogenase C over-expression in Chinese hamster ovary cells

scientific article published on 3 February 2016

Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors

scientific article

Structural Basis for Treating Tumor Necrosis Factor (TNF )-associated Diseases with the Therapeutic Antibody Infliximab

scientific article

Suppression of Rituximab-resistant B-cell lymphoma with a novel multi-component anti-CD20 mAb nanocluster

scientific article

TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU.

scientific article published on July 2006

TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression

scientific article published on 13 November 2006

The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors ⬇️

scientific article published on March 5, 2011

The finely regulating well-defined functional polymeric nanocarriers for anti-tumor immunotherapy

scientific article published on April 2013

Therapeutic efficacy of an anti-PD-L1 antibody based immunocytokine in a metastatic mouse model of colorectal cancer

scientific article

Thirty-kilodalton Tat-interacting protein suppresses tumor metastasis by inhibition of osteopontin transcription in human hepatocellular carcinoma

scientific article

Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

scientific article

Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome

scientific article published on 13 April 2007

Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments

scientific article published on 01 October 2008

Treatment of hepatocellular carcinoma with adenoviral vector-mediated Flt3 ligand gene therapy

scientific article

List of works by Jianxin Dai

A bispecific antibody effectively neutralizes all four serotypes of dengue virus by simultaneous blocking virus attachment and fusion

A chimeric SM5-1 antibody inhibits hepatocellular carcinoma cell growth and induces caspase-dependent apoptosis

A functional motif QLYxxYP is essential for osteopontin induced T lymphocyte activation and migration

A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo

A humanized anti-osteopontin antibody protects from Concanavalin A induced-liver injury in mice ⬇️

A novel functional motif of osteopontin for human lymphocyte migration and survival

Acid-induced aggregation propensity of nivolumab is dependent on the Fc.

Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis.

Antibody-targeted immunoliposomes for cancer treatment

Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance

CD20 Antibody-Conjugated Immunoliposomes for Targeted Chemotherapy of Melanoma Cancer Initiating Cells

Cancer immunotherapy using in vitro genetically modified targeted dendritic cells

Characterization of alanine to valine sequence variants in the Fc region of nivolumab biosimilar produced in Chinese hamster ovary cells

Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles ⬇️

Combating non-Hodgkin lymphoma by targeting both CD20 and HLA-DR through CD20-243 CrossMab

Combination of dextran sulfate and recombinant trypsin on aggregation of Chinese hamster ovary cells

Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody

Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions

Development of SM5-1-conjugated ultrasmall superparamagnetic iron oxide nanoparticles for hepatoma detection

Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity

Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis.

Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU.

Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP.

Expression, purification, and characterization of an immunotoxin containing a humanized anti-CD25 single-chain fragment variable antibody fused to a modified truncated Pseudomonas exotoxin A.

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab

Functional and stable expression of recombinant human FOXP3 in bacterial cells and development of antigen-specific monoclonal antibodies

Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency

Genetically targeted T cells eradicate established breast cancer in syngeneic mice

In-Depth Characterization of a Pro-Antibody-Drug Conjugate by LC-MS.

Increased expression of iASPP, regulated by hepatitis B virus X protein-mediated NF-κB activation, in hepatocellular carcinoma

Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA.

Lysosome-dependent necrosis specifically evoked in cancer cells by gold nanorods

Molecular Basis of Recognition of Human Osteopontin by 23C3, a Potential Therapeutic Antibody for Treatment of Rheumatoid Arthritis

Nano polymeric carrier fabrication technologies for advanced antitumor therapy

Novel Dual-Control Poly( N -Isopropylacrylamide- Co -Chlorophyllin) Nanogels for Improving Drug Release ⬇️

PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumor progression with reduced toxicity and immunogenicity

Phase I trial of a humanized, Fc receptor nonbinding anti-CD3 antibody, hu12F6mu in patients receiving renal allografts

Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma

Potent Neutralization of Botulinum Neurotoxin/B by Synergistic Action of Antibodies Recognizing Protein and Ganglioside Receptor Binding Domain ⬇️

Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy

Preparation and Characterization of Paclitaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody

Preparation and characterization of recombinant protein ScFv(CD11c)-TRP2 for tumor therapy from inclusion bodies in Escherichia coli

Regulation of cell growth and apoptosis through lactate dehydrogenase C over-expression in Chinese hamster ovary cells

Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors

Structural Basis for Treating Tumor Necrosis Factor (TNF )-associated Diseases with the Therapeutic Antibody Infliximab

Suppression of Rituximab-resistant B-cell lymphoma with a novel multi-component anti-CD20 mAb nanocluster

TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU.

TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression

The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors ⬇️

The finely regulating well-defined functional polymeric nanocarriers for anti-tumor immunotherapy

Therapeutic efficacy of an anti-PD-L1 antibody based immunocytokine in a metastatic mouse model of colorectal cancer

Thirty-kilodalton Tat-interacting protein suppresses tumor metastasis by inhibition of osteopontin transcription in human hepatocellular carcinoma

Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome

Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments

Treatment of hepatocellular carcinoma with adenoviral vector-mediated Flt3 ligand gene therapy