Search filters

List of works by K-U Wagner

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

scientific article

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.

scientific article published on December 2008

AKT3 drives adenoid cystic carcinoma development in salivary glands

scientific article published on 28 December 2017

Acceleration of Bcr-Abl+ leukemia induced by deletion of JAK2.

scientific article published on 5 May 2014

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

scientific article

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies

scientific article published on 26 March 2014

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.

scientific article

Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

scientific article published on 05 December 2016

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

scientific article published on 27 March 2013

Cre-mediated gene deletion in the mammary gland ⬇️

scientific article published on November 1, 1997

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

scientific article

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

scientific article

Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression ⬇️

scientific article published on October 28, 2011

Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

scientific article

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

scientific article published on 20 December 2012

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

scientific article

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

scientific article published on 6 March 2013

ESCRT proteins: Double-edged regulators of cellular signaling ⬇️

scientific article published on January 1, 2011

Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus

scientific article published on 14 January 2020

Erythropoietin protects against diabetes through direct effects on pancreatic β cells ⬇️

scientific article published on December 13, 2010

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax

scientific article published on 03 January 2011

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

scientific article published on 2 April 2013

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung

scientific article

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

scientific article published on 27 September 2016

Generation of a Novel MMTV-tTA Transgenic Mouse Strain for the Targeted Expression of Genes in the Embryonic and Postnatal Mammary Gland ⬇️

scientific article published on August 31, 2012

Generation of conditional knockout mice.

scientific article published in January 2014

Genetically engineered mucin mouse models for inflammation and cancer.

scientific article published on 30 January 2015

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

scientific article published on 7 October 2016

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

scientific article published on 20 July 2017

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance ⬇️

scientific article published on January 24, 2012

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice.

scientific article

IRF4 is a suppressor of c-Myc induced B cell leukemia.

scientific article

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

scientific article published on October 2011

Jak2 is necessary for neuroendocrine control of female reproduction

scientific article

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

scientific article published on 04 April 2016

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

scientific article published on 01 November 2018

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

scientific article published on 18 January 2017

Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer

scientific journal article

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

scientific article

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

scientific article

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.

scientific article published on April 2009

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

scientific journal article

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

scientific article published on 6 June 2013

Loss of Jak2 protects cardiac allografts from chronic rejection by attenuating Th1 response along with increased regulatory T cells

scientific article published on 15 February 2019

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

scientific article

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

scientific article published on 10 February 2017

Mouse models of breast cancer

scientific article published on January 2015

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

scientific article

Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis

scientific article published on 08 October 2012

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.

scientific article published on 13 October 2015

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

scientific article published on 15 September 2021

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells

scientific article

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

scientific article published on 12 July 2021

Regulation and New Treatment Strategies in Breast Cancer

scientific article published on 01 December 2019

Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.

scientific article published on 7 February 2014

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

scientific article published on June 2012

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

scientific article

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

scientific article published on 27 January 2014

Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

scientific article published on 30 July 2020

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

scientific article

The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease

scientific article published on 14 February 2020

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

scientific article

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling ⬇️

scientific article published on October 25, 2010

Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity

scientific article published on 01 March 2021

Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R

scientific article published on 18 March 2019

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

scientific article

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species ⬇️

scientific article published on February 24, 2011

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

scientific article

Paulina is supported by:

About Paulina

Help