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List of works by Stephen J Pettitt

A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

scientific article

ATR Is a Therapeutic Target in Synovial Sarcoma.

scientific article published on 16 October 2017

Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

scientific article published in Scientific Reports

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

scientific article published on 13 July 2018

Clinical BRCA1/2 reversion analysis identifies hotspot mutations and predicted neoantigens associated with therapy resistance

scientific article published on 22 July 2020

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

scientific article

Dissecting PARP inhibitor resistance with functional genomics

scientific article published on 01 February 2019

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

scientific article published in April 2018

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

scientific article

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

scientific article published in 2022

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

scientific article published on 10 May 2018

Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

scientific article

Genome-wide forward genetic screens in mouse ES cells.

scientific article

Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer

scientific article published on 18 June 2018

Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system.

scientific article published on 29 November 2011

Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR

scientific article published on 20 November 2019

Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer

scientific article

Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

scientific article published on 15 June 2017

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

article by Roman M Chabanon et al published 1 March 2019 in Journal of Clinical Investigation

Phase I trial of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib and AKT inhibitor capivasertib in patients with BRCA1/2 and non-BRCA1/2 mutant cancers

scientific article published on 12 June 2020

Structural basis for allosteric PARP-1 retention on DNA breaks

scientific article

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

scientific article published in May 2018

The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites

scientific article published on 28 January 2013

The shieldin complex mediates 53BP1-dependent DNA repair

scientific article published in Nature

piggyBac transposon-based insertional mutagenesis in mouse haploid embryonic stem cells

scientific article

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