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List of works by Claudio D'Amore

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

scientific article published on 20 January 2012

An NBD Derivative of the Selective Rat Toxicant Norbormide as a New Probe for Living Cell Imaging

scientific article

An intracellular adrenomedullin system reduces IL-6 release via a NF-kB-mediated, cAMP-independent transcriptional mechanism in rat thymic epithelial cells.

scientific article published on 9 September 2016

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.

scientific article published on 28 May 2014

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

scientific article

CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination.

scientific article

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

scientific article

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

scientific article published on 17 January 2014

Diethylstilbestrol-scaffold-based pregnane X receptor modulators

scientific article published on 08 September 2015

Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.

scientific article published on 08 July 2013

Dopamine-mediated immunomodulation affects choroid plexus function

scientific article published on 05 June 2019

Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice.

scientific article published on 30 April 2013

Epigenetic Modulation by Methionine Deficiency Attenuates the Potential for Gastric Cancer Cell Dissemination ⬇️

scientific article published on September 5, 2012

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

scientific article

FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity ⬇️

scientific article published on September 15, 2011

FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.

scientific article published in September 2013

Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.

scientific article published on 4 February 2011

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.

scientific article published on 23 March 2012

HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes.

scientific article

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

scientific article published on 15 July 2015

In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors

scientific article published on 4 December 2013

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists.

scientific article

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

scientific article

Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei.

scientific article published on 15 June 2013

Live applications of norbormide-based fluorescent probes in Drosophila melanogaster

scientific article published on 08 April 2019

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation

scientific article

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

scientific article

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)

scientific article published on 07 September 2014

New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.

scientific article published on 13 August 2013

Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.

scientific article published on 2 July 2013

Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata.

scientific article published on 18 June 2016

Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor.

scientific article published on 3 April 2014

Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor.

scientific article

Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner

scientific article published on 25 January 2012

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts ⬇️

scientific article published on January 29, 2011

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

scientific article published on 24 December 2013

The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.

scientific article

The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes ⬇️

scientific article published on April 30, 2012

The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines.

scientific article published on 07 July 2016

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate

scientific article

Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.

scientific article

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation ⬇️

scientific article published on September 21, 2012

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