List of works - Frans Gorus

A composite immune signature parallels disease progression across T1D subjects

scientific article published on 05 December 2019

A novel LIPS assay for insulin autoantibodies.

scientific article

A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes

scientific article published on 04 November 2020

Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A24 and -B18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.

scientific article published on 15 March 2018

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65.

scientific article published on 8 March 2018

Clusters of conserved beta cell marker genes for assessment of beta cell phenotype

scientific article

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D

scientific article published on 01 February 2019

Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

scientific article published on June 2017

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death

scientific article

Early alteration of kidney function in nonuremic type 1 diabetic islet transplant recipients under tacrolimus-mycophenolate therapy

scientific article

Evaluation of the Sebia Capillarys 3 Tera and the Bio-Rad D-100 Systems for the Measurement of Hemoglobin A1c.

scientific article

HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft

scientific article published on 26 April 2016

Hyperglycemic clamp and oral glucose tolerance test for 3-year prediction of clinical onset in persistently autoantibody-positive offspring and siblings of type 1 diabetic patients.

scientific article published on 18 November 2014

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review

scientific article published on 01 September 2019

Minimal functional β-cell mass in intraportal implants that reduces glycemic variability in type 1 diabetic recipients.

scientific article published on 16 September 2013

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

scientific article published on 27 March 2015

Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.

scientific article

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio.

scientific article

Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts.

scientific article published in July 2013

Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease:

scientific article

Predictors of progression to Type 1 diabetes: preparing for immune interventions in the preclinical disease phase

scientific article published on December 2013

Preexisting insulin autoantibodies predict efficacy of otelixizumab in preserving residual β-cell function in recent-onset type 1 diabetes

scientific article

Protein markers for insulin-producing beta cells with higher glucose sensitivity

scientific article (publication date: 6 December 2010)

Relationship between glycaemic variability and hyperglycaemic clamp-derived functional variables in (impending) type 1 diabetes.

scientific article published on 26 September 2015

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients

scientific article published on 20 April 2018

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes.

scientific article published on 12 July 2017

List of works by Frans Gorus

A composite immune signature parallels disease progression across T1D subjects

A novel LIPS assay for insulin autoantibodies.

A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes

Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65.

Clusters of conserved beta cell marker genes for assessment of beta cell phenotype

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D

Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death

Early alteration of kidney function in nonuremic type 1 diabetic islet transplant recipients under tacrolimus-mycophenolate therapy

Evaluation of the Sebia Capillarys 3 Tera and the Bio-Rad D-100 Systems for the Measurement of Hemoglobin A1c.

HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft

Hyperglycemic clamp and oral glucose tolerance test for 3-year prediction of clinical onset in persistently autoantibody-positive offspring and siblings of type 1 diabetic patients.

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review

Minimal functional β-cell mass in intraportal implants that reduces glycemic variability in type 1 diabetic recipients.

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio.

Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts.

Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease:

Predictors of progression to Type 1 diabetes: preparing for immune interventions in the preclinical disease phase

Preexisting insulin autoantibodies predict efficacy of otelixizumab in preserving residual β-cell function in recent-onset type 1 diabetes

Protein markers for insulin-producing beta cells with higher glucose sensitivity

Relationship between glycaemic variability and hyperglycaemic clamp-derived functional variables in (impending) type 1 diabetes.

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes.

Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A24 and -B18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.