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List of works by Melissa Sykes

(-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata ⬇️

scientific article

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

scientific article published on 16 May 2013

3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition

scientific article published on 20 March 2018

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

scientific article published on 6 August 2015

7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.

scientific article published on 25 May 2010

Alkaloids from the Chinese vine Gnetum montanum ⬇️

scientific article

Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia.

scientific article published on 26 June 2010

Antitrypanosomal cyclic polyketide peroxides from the Australian marine sponge Plakortis sp.

scientific article published in April 2010

Approaches to protozoan drug discovery: phenotypic screening.

scientific article published on 20 August 2013

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

scientific article (publication date: 17 November 2016)

Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa.

scientific article

Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity

scientific article published on 11 December 2018

Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes

scientific article

Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

scientific article published in October 2009

Ianthelliformisamines A-C, antibacterial bromotyrosine-derived metabolites from the marine sponge Suberea ianthelliformis. ⬇️

scientific article

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

scientific article

Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites

scientific article published on 12 March 2020

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp. ⬇️

scientific article published on 17 May 2012

Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata ⬇️

scientific article published on 25 December 2007

New galloylated flavanonols from the Australian plant Glochidion sumatranum. ⬇️

scientific article published in July 2010

Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.

scientific article published on 17 August 2011

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.

scientific article

Screening a Natural Product-Based Library against Kinetoplastid Parasites.

scientific article published on 12 October 2017

Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

scientific article

Solving the supply of resveratrol tetramers from Papua New Guinean rainforest anisoptera species that inhibit bacterial type III secretion systems ⬇️

scientific article

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

scientific article published on 01 July 2019

Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone

scientific article published on 09 July 2019

Trypanocidal activity of marine natural products

scientific article

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni

article

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