List of works - Toshiro Takai

Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation.

scientific article published on 31 January 2018

Allergens in modern society: Updated catalogs and future prospects

scientific article published in October 2015

Barrier Dysfunction Caused by Environmental Proteases in the Pathogenesis of Allergic Diseases ⬇️

scientific article published on December 25, 2011

Cedar allergen harvest from tobacco: plant biotechnology for recombinant allergens

scientific article published on 14 July 2010

Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo

scientific article published on 28 October 2009

Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33

scientific article published on 15 July 2019

Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.

scientific article

Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA

scientific article published on 03 December 2008

Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies ⬇️

scientific article published on February 1, 1997

Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy ⬇️

scientific article published on August 1, 1997

Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: a useful tool for the study of allergies in mouse models.

scientific article published on 25 March 2009

Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

scientific article published on 14 March 2016

Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner.

scientific article published on 25 March 2014

Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB-dependent pathway in human keratinocytes

scientific article published on 30 June 2011

Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via toll-like receptor 5

scientific article published on 25 November 2010

Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S ⬇️

scientific article published on July 1, 1998

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.

scientific article

Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin e synthesis

scientific article published on 15 May 2012

Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.

scientific article published on 27 March 2009

Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain

scientific article published on 17 December 2015

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines - secondary publication.

scientific article published on 4 March 2015

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes

scientific article published on 30 March 2012

Missions of Protease Allergens in the Epithelium ⬇️

scientific article published on July 24, 2010

Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes.

scientific article

Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand.

scientific article published in December 2009

NADPH oxidase activity in allergenic pollen grains of different plant species.

scientific article published on 10 July 2009

Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern

scientific article published on 15 May 2015

Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice

scientific article published on 12 August 2015

Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression

scientific article published on 29 March 2011

Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets

scientific article published on 29 August 2014

Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice

scientific article published on 01 March 2017

Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction.

scientific article published on 8 October 2009

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway

scientific article published on 01 November 2010

Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes.

scientific article published on 21 March 2016

TSLP expression induced via Toll-like receptor pathways in human keratinocytes

scientific article published on 01 January 2014

TSLP expression: cellular sources, triggers, and regulatory mechanisms.

scientific article published on 25 January 2012

The epithelium takes center stage in allergic keratoconjunctivitis.

scientific article

Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocytes

scientific article published on 26 February 2011

List of works by Toshiro Takai

Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation.

Allergens in modern society: Updated catalogs and future prospects

Barrier Dysfunction Caused by Environmental Proteases in the Pathogenesis of Allergic Diseases ⬇️

Cedar allergen harvest from tobacco: plant biotechnology for recombinant allergens

Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo

Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33

Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.

Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA

Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies ⬇️

Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy ⬇️

Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: a useful tool for the study of allergies in mouse models.

Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner.

Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB-dependent pathway in human keratinocytes

Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via toll-like receptor 5

Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S ⬇️

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.

Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin e synthesis

Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.

Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines - secondary publication.

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes

Missions of Protease Allergens in the Epithelium ⬇️

Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes.

Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand.

NADPH oxidase activity in allergenic pollen grains of different plant species.

Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern

Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice

Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression

Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets

Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice

Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction.

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway

Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes.

TSLP expression induced via Toll-like receptor pathways in human keratinocytes

TSLP expression: cellular sources, triggers, and regulatory mechanisms.

The epithelium takes center stage in allergic keratoconjunctivitis.

Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocytes