List of works - Jessica K Holien

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

scientific article

A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.

scientific article published on 20 December 2016

A mechanism for the extension and unfolding of parallel G-quadruplexes by human telomerase at single-molecule resolution

scientific article published on 29 July 2020

A structural view of PA2G4 isoforms with opposing functions in cancer

scientific article published on 20 September 2020

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

scientific article published on 5 May 2014

AMP and adenosine are both ligands for adenosine 2B receptor signaling.

scientific article published on 20 November 2017

Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase

scientific article published on 27 July 2011

An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia

scientific article published on 09 June 2011

Computational Analysis of Amiloride Analogue Inhibitors of Coxsackievirus B3 RNA Polymerase

scientific article

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.

scientific article

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

scientific article published on 26 December 2014

Direct involvement of the TEN domain at the active site of human telomerase

scientific article

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

scientific article

Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V

scientific article

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

scientific article published on 09 September 2019

Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency

scientific article published on 7 September 2015

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

scientific article

Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma

scientific article published on 19 July 2020

Improvements, trends, and new ideas in molecular docking: 2012-2013 in review.

scientific article published on 21 March 2015

In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.

scientific article published on 03 August 2009

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

scientific article

Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin

scientific article

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

scientific article published on 20 November 2015

Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34

scientific article published on 08 May 2013

Oncogenic protein interfaces: small molecules, big challenges.

scientific article published on 13 March 2014

Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses.

scientific article

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

scientific article published on 13 July 2010

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

scientific article published on 5 April 2013

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

scientific article published in 2021

Sequence comparisons of cytochrome P450 aromatases from Australian animals predict differences in enzymatic activity and/or efficiency

scientific article published on 17 March 2020

Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity

scientific article

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

scientific article published on 7 February 2014

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

scientific article

The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.

scientific article

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

scientific article

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.

scientific article

Zanamivir-resistant influenza viruses with a novel neuraminidase mutation

scientific article

List of works by Jessica K Holien

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.

A mechanism for the extension and unfolding of parallel G-quadruplexes by human telomerase at single-molecule resolution

A structural view of PA2G4 isoforms with opposing functions in cancer

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

AMP and adenosine are both ligands for adenosine 2B receptor signaling.

Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase

An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia

Computational Analysis of Amiloride Analogue Inhibitors of Coxsackievirus B3 RNA Polymerase

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

Direct involvement of the TEN domain at the active site of human telomerase

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma

Improvements, trends, and new ideas in molecular docking: 2012-2013 in review.

In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34

Oncogenic protein interfaces: small molecules, big challenges.

Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses.

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Sequence comparisons of cytochrome P450 aromatases from Australian animals predict differences in enzymatic activity and/or efficiency

Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.

Zanamivir-resistant influenza viruses with a novel neuraminidase mutation