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List of works by Hermann Altmeppen

Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment.

scientific article published on 25 January 2012

Aluminium per se and in the anti-acid drug sucralfate promotes sensitization via the oral route.

scientific article published on 5 February 2009

Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake

scientific article published on 27 August 2020

Diverse functions of the prion protein - Does proteolytic processing hold the key?

scientific article

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.

scientific article published on 28 December 2015

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

scientific article published on 04 January 2019

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease.

scientific article published on 10 February 2014

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.

scientific article published on 8 March 2018

Infectious prions do not induce Aβ deposition in an in vivo seeding model

scientific article published on 16 April 2018

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

scientific journal article

Misfolding leads the way to unraveling signaling pathways in the pathophysiology of prion diseases.

scientific article published on 21 November 2016

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

scientific article published on 30 August 2018

N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells.

scientific article

NeuroCOVID: Insights into Neuroinvasion and Pathophysiology

scientific article published on 05 April 2022

Pharmacological inactivation of the prion protein by targeting a folding intermediate

scientific article published on 12 January 2021

Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

scientific article published in August 2013

Proteolytic processing of the prion protein in health and disease.

scientific article published on 15 May 2012

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.

scientific article published on 13 March 2013

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

scientific article published on 27 April 2016

Shedding light on prion disease.

scientific article published on 17 July 2015

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

scientific article published on 6 April 2018

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.

scientific article published on 3 November 2016

The GPI-anchoring of PrP: implications in sorting and pathogenesis.

scientific article published on January 2014

The cellular prion protein and its derived fragments in human prion diseases and their role as potential biomarkers

scientific article published on 26 September 2019

The sheddase ADAM10 is a potent modulator of prion disease.

scientific article

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

scientific article published on 04 May 2020

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