List of works - Herbert Spapen

'Biomarking' infection during continuous renal replacement therapy: still relevant?

scientific article published on 21 May 2015

A Double Catheter Approach for Extracorporeal CO Removal Integrated Within a Continuous Renal Replacement Circuit

scientific article published on 31 December 2018

A fresh look into the pathophysiology of ischemia-induced complications in patients with chronic kidney disease undergoing hemodialysis.

scientific article published on 13 March 2015

A newly developed tracheal tube offering 'pressurised sealing' outperforms currently available tubes in preventing cuff leakage: A benchtop study.

scientific article published on 29 July 2016

A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients

scientific article published on 04 February 2017

AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital

scientific article

Adjuvant vitamin C in cardiac arrest patients undergoing renal replacement therapy: an appeal for a higher high-dose

scientific article published on 16 August 2018

Adjuvant vitamin C treatment in sepsis-how many oranges a day keep (vasopressor-dependent) septic shock away?

scientific article published on September 2016

An endotracheal tube providing "pressurized sealing" prevents fluid leakage in mechanically ventilated critically ill patients: a pilot study

scientific article published on 05 November 2019

An unusual case of acute psychosis in an adolescent.

scientific article published on March 2013

An update on membranes and cartridges for extracorporeal blood purification in sepsis and septic shock

scientific article published on 01 December 2018

Anidulafungin dosing during CRRT: do not underestimate adsorption!

scientific article published on 30 October 2014

BPI fold-containing family a member 2 as a biomarker of acute kidney injury-close but no (clinical) cigar?

scientific article

Balanced crystalloids for the critically ill: knowledge on the rise but confusion still reigns!

scientific article published in October 2017

Beneficial effects of antioxidant therapy in crush syndrome in a rodent model: enough evidences to be used in humans?

scientific article published on 27 September 2018

Biomarker validity in the critically ill: all must face the (continuous) renal replacement challenge!

scientific article

Biomarkers in critical illness: have we made progress?

scientific article

Biomarkers of inflammation during continuous renal replacement therapy: sensors, players, or targets? A reply to the letter by Villa et al.

scientific article published on 17 October 2014

CO2 and O2 removal during continuous veno-venous hemofiltration: a pilot study

scientific article published on 17 June 2019

Cefepime-induced neurotoxicity in critically ill patients undergoing continuous renal replacement therapy: beware of dose reduction!

scientific article published on 30 December 2015

Chest physiotherapy in mechanically ventilated patients without pneumonia-a narrative review

scientific article published on January 2017

Chloride content of solutions used for regional citrate anticoagulation might be responsible for blunting correction of metabolic acidosis during continuous veno-venous hemofiltration.

scientific article

Citrate Formulation Determines Filter Lifespan during Continuous Veno-Venous Hemofiltration: A Prospective Cohort Study.

scientific article published on 22 August 2015

Citrate: How to get started and what, when, and how to monitor?

scientific article published on 01 September 2018

Clinical benefit of high-volume hemofiltration in severe burn injury: is it removing bad humors or actually avoiding hypervolemia?

scientific article published in November 2018

Colistin pharmacokinetics/pharmacodynamics and acute kidney injury: A difficult but reasonable marriage.

scientific article published on July 2014

Con: Dialy- and continuous renal replacement (CRRT) trauma during renal replacement therapy: still under-recognized but on the way to better diagnostic understanding and prevention.

scientific article published in November 2013

Condensation of humidified air in the inflation line of a polyurethane cuff precludes correct continuous pressure monitoring during mechanical ventilation.

scientific article published on 23 May 2014

Continuous renal replacement therapy for safe and adequate voriconazole intravenous treatment: enough reason to be confident?

scientific article published on 27 May 2015

Correction to: CO2 and O2 removal during continuous veno-venous hemofiltration: a pilot study

scientific article published on 08 August 2019

Correction to: Chloride content of solutions used for regional citrate anticoagulation might be responsible for blunting correction of metabolic acidosis during continuous venovenous hemofiltration

scientific article published on 24 March 2020

Dexmedetomidine: the first new kid on the block for preventing cardiac surgery-associated acute kidney injury?

scientific article published on 5 June 2018

Diffuse alveolar haemorrhage with predominant upper lung lobe involvement associated with congestive heart failure: a case series.

scientific article published in October 2017

Do Statins Induce or Protect from Acute Kidney Injury and Chronic Kidney Disease: An Update Review in 2018

scientific article published on 28 March 2018

Dosing adjuvant vitamin C in critically ill patients undergoing continuous renal replacement therapy: We are not there yet!

scientific article published on 09 January 2019

Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002.

scientific article published on February 2017

Editorial over the Many Faces of Vitamin D in Chronic Kidney Disease: from Mineral to Immune-Inflammatory Modulator

scientific article published on 24 November 2017

Efficacy of polymyxin B hemoperfusion in and beyond septic shock: is an "endotoxin severity score" needed?

scientific article published on 17 August 2018

Efficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients-a randomized clinical trial

scientific article published on 04 March 2020

Eliminating endotoxin by polymyxin B hemoperfusion and/or continuous renal replacement therapy: should the focus be on timing, dosing, and type of renal epuration?

scientific article published on 08 March 2019

Energy expenditure of patients on ECMO: A prospective pilot study

scientific article published on 06 November 2018

Eravacycline for treatment of complicated intra-abdominal infections: the fire is not ignited!

scientific article

Evolution of Vascular Access and Anticoagulation

scientific article published on 29 March 2018

Facing acid-base disorders in the third millennium - the Stewart approach revisited.

scientific article

Feasibility of cerebral magnetic resonance imaging in patients with externalised spinal cord stimulator.

scientific article published on 22 October 2011

Fondaparinux: another potential treatment for heparin-induced thrombocytopenia type II?

scientific article published on 27 January 2016

Fulminant myocarditis in children. Continuous renal replacement therapy to the rescue?

scientific article published in November 2017

Hemoadsorption therapy in the critically ill: solid base but clinical haze

scientific article published on 31 January 2019

Heparin-binding protein in sepsis: player! predictor! positioning?

scientific article published on 20 June 2019

High-frequency percussive ventilation in acute respiratory distress syndrome: knocking at the door but can it be let in?

scientific article published on 2 March 2018

Higher colistin dose during continuous renal replacement therapy: look before leaping!

scientific article published on 8 June 2015

How to deal with severe acute pancreatitis in the critically ill

scientific article published on 01 April 2019

Hyperchloremia-associated acute chronic kidney injury: beware of confounders!

scientific article published on 10 January 2019

Immunoadsorption versus therapeutic plasma exchange. Will fibrinogen make the difference?

scientific article published on 04 December 2014

Impact of maintenance, resuscitation and unintended fluid therapy on global fluid load after elective coronary artery bypass surgery

scientific article published on 01 November 2018

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project.

scientific article published on 14 June 2019

Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

scientific article

Intertwining extracorporeal membrane oxygenation and continuous renal replacement therapy: sense or nonsense?

scientific article published on 25 March 2015

Is neutrophil gelatinase-associated lipocalin unaffected by convective continuous renal replacement therapy? Definitely … maybe.

scientific article published on 17 November 2015

Lactate: the Black Peter in high-risk gastrointestinal surgery patients.

scientific article published on June 2016

Look before leaping into combining extracorporeal techniques to improve oxygenation!

scientific article published on 22 September 2015

Measuring resting energy expenditure during extracorporeal membrane oxygenation: preliminary clinical experience with a proposed theoretical model

scientific article published on 5 June 2015

Meropenem therapy in extracorporeal membrane oxygenation patients: an ongoing pharmacokinetic challenge

scientific article published on 22 June 2015

Metabolic and coagulation effects of citrate: down to the last detail!

scientific article published on 12 December 2015

Nebulized colistin for treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: we still need to straighten out the dose!

scientific article published on 26 June 2015

Neutrophil gelatinase-associated lipocalin elimination by renal replacement therapy: minding the membrane!

scientific article published on 5 April 2016

New generation indirect calorimeters for measuring energy expenditure in the critically ill: a rampant or reticent revolution?

scientific article published on 5 June 2016

Nobiletin: A Citrus Isolate to Make Sepsis Less Sour.

scientific article

Normal saline as resuscitation fluid in critically ill patients: not dead yet!

scientific article published on 28 December 2016

Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial

scientific article published on 22 April 2015

Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?

scientific article

Optimizing citrate dose for regional anticoagulation in continuous renal replacement therapy: measuring citrate concentrations instead of ionized calcium?

scientific article published on 6 November 2015

Optimizing micafungin dosing in critically ill patients: what about extracorporeal therapies?

scientific article published on 01 November 2018

Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?

scientific article published on 2 June 2017

Outcome Prediction of Acute Kidney Injury Biomarkers at Initiation of Dialysis in Critical Units

scientific article published on 06 August 2018

Oxidative stress markers and septic acute kidney injury: Novel research avenue or road to nowhere?

scientific article published on 10 October 2016

Passive leg raising test with minimally invasive monitoring: the way forward for guiding septic shock resuscitation?

scientific article

Pentraxin-3 to better delineate necrotizing soft tissue infection: not really!

scientific article published on 17 June 2016

Peri-operative fluid strategy and post-operative acute kidney injury in cardiac surgery patients: any role for pre-operative statin therapy?

scientific article published on 29 December 2015

Pharmacokinetics and Pharmacodynamics of Anti-infective Agents during Continuous Veno-venous Hemofiltration in Critically Ill Patients: Lessons Learned from an Ancillary Study of the IVOIRE Trial

scientific article published on 31 December 2019

Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy

scientific article published on 13 April 2011

Presepsin and sepsis-induced acute kidney injury treated with continuous renal replacement therapy: will another promising biomarker bite the dust?

scientific article published on 15 December 2015

Prognosis of extremely severe lactic acidosis in metformin-treated patients with septic shock: continuous (?) renal replacement therapy in the spotlight!

scientific article published on 7 May 2016

Propofol infusion syndrome: early blood purification to the rescue?

scientific article published on 4 July 2016

Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy: All Citrates Are Not Created Equal!

scientific article

Remote ischemic preconditioning to prevent cardiac surgery-related acute kidney injury: how far away from a breakthrough?

scientific article published on August 2016

Renal blood flow and acute kidney injury in septic shock: an arduous conflict that smolders intrarenally?

scientific article

Renal protection in sepsis: Is hypertonic sodium (lactate) the solution?

scientific article published on 08 February 2019

Renal tubular acidosis with hyperchloremic acidosis: harmless with a sting?

scientific article published on 28 August 2015

Retrograde C0-C1 insertion of cervical plate electrode for chronic intractable neck and arm pain.

scientific article published in September 2011

Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

scientific article

Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients.

scientific article published on 15 August 2017

Some metabolic issues should not be neglected when using citrate for continuous renal replacement therapy!

scientific article

Statins and the Kidney: Friend or Foe?

scientific article published on 13 December 2016

Statins barely touch the heart but bite the kidneys after cardiac surgery. Coenzyme Q10 deficiency in the dock?

scientific article published on October 2016

The CoCoS trial: Caloric Control in Cardiac Surgery patients promotes survival, an interventional trial with retrospective control

scientific article published on 18 March 2017

The blind spot in high-dose tigecycline pharmacokinetics in critically ill patients: membrane adsorption during continuous extracorporeal treatment

scientific article

The struggle to differentiate inflammation from infection in severely burned patients: time to send better biomarkers into the arena?

scientific article published on 20 January 2016

Timing of renal replacement therapy in critically ill patients: where are the hands on the clock?

scientific article published on September 2016

To counteract or to clear high-mobility group box-1 protein in influenza A (H1N1) infection? That may become the question

scientific article published on 23 November 2015

Treatment of Ventilator-associated Pneumonia with High-dose Colistin Under Continuous Veno-venous Hemofiltration

scientific article published on 01 September 2019

Ulinastatin to prevent acute kidney injury after cardiopulmonary bypass surgery: does serum creatinine tell the whole story?

scientific article published on July 2016

Unidentified cachexia patients in the oncologic setting: Cachexia UFOs do exist

scientific article published on 27 February 2019

Uremic Fetor Revisited: Exhaled Volatile Biomarkers in Acute Kidney Injury

scientific article published on 01 February 2019

VCO2 calorimetry: stop tossing stones, it's time for building!

scientific article published on 16 December 2016

Validity of the relationship between mobility group box-1 protein and poor post-cardiac arrest neurological outcome during renal replacement therapy

scientific article published on 12 March 2019

Vancomycin pharmacokinetics in critically ill obese patients: can the clinician sit back and relax?

scientific article published on 17 January 2019

Vasopressin versus noradrenaline as initial therapy in septic shock. Is vasopressin-related renal protection doomed to "vanish" in the haze?

scientific article published on October 2016

Vitamin C Dosing During Continuous Renal Replacement Therapy: The Last Word is Not Said!

scientific article published on 06 August 2019

What a Clinician Should Know About a Renal Replacement Membrane?

scientific article published on 26 June 2018

What do we know about steroids metabolism and 'PK/PD approach' in AKI and CKD especially while on RRT--current status in 2014

scientific article

What's new in emergencies, trauma, and shock: Intentional or accidental hypothermia in Intensive Care Unit patients: Time to strike the colors?

scientific article published on July 2016

pharmacokinetics/pharmacodynamics; renal replacement therapy, continuous; antibiotics; antifungals

scientific article published on 24 November 2017

List of works by Herbert Spapen

'Biomarking' infection during continuous renal replacement therapy: still relevant?

A Double Catheter Approach for Extracorporeal CO Removal Integrated Within a Continuous Renal Replacement Circuit

A fresh look into the pathophysiology of ischemia-induced complications in patients with chronic kidney disease undergoing hemodialysis.

A newly developed tracheal tube offering 'pressurised sealing' outperforms currently available tubes in preventing cuff leakage: A benchtop study.

A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients

AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital

Adjuvant vitamin C in cardiac arrest patients undergoing renal replacement therapy: an appeal for a higher high-dose

Adjuvant vitamin C treatment in sepsis-how many oranges a day keep (vasopressor-dependent) septic shock away?

An endotracheal tube providing "pressurized sealing" prevents fluid leakage in mechanically ventilated critically ill patients: a pilot study

An unusual case of acute psychosis in an adolescent.

An update on membranes and cartridges for extracorporeal blood purification in sepsis and septic shock

Anidulafungin dosing during CRRT: do not underestimate adsorption!

BPI fold-containing family a member 2 as a biomarker of acute kidney injury-close but no (clinical) cigar?

Balanced crystalloids for the critically ill: knowledge on the rise but confusion still reigns!

Beneficial effects of antioxidant therapy in crush syndrome in a rodent model: enough evidences to be used in humans?

Biomarker validity in the critically ill: all must face the (continuous) renal replacement challenge!

Biomarkers in critical illness: have we made progress?

Biomarkers of inflammation during continuous renal replacement therapy: sensors, players, or targets? A reply to the letter by Villa et al.

CO2 and O2 removal during continuous veno-venous hemofiltration: a pilot study

Cefepime-induced neurotoxicity in critically ill patients undergoing continuous renal replacement therapy: beware of dose reduction!

Chest physiotherapy in mechanically ventilated patients without pneumonia-a narrative review

Chloride content of solutions used for regional citrate anticoagulation might be responsible for blunting correction of metabolic acidosis during continuous veno-venous hemofiltration.

Citrate Formulation Determines Filter Lifespan during Continuous Veno-Venous Hemofiltration: A Prospective Cohort Study.

Citrate: How to get started and what, when, and how to monitor?

Clinical benefit of high-volume hemofiltration in severe burn injury: is it removing bad humors or actually avoiding hypervolemia?

Colistin pharmacokinetics/pharmacodynamics and acute kidney injury: A difficult but reasonable marriage.

Con: Dialy- and continuous renal replacement (CRRT) trauma during renal replacement therapy: still under-recognized but on the way to better diagnostic understanding and prevention.

Condensation of humidified air in the inflation line of a polyurethane cuff precludes correct continuous pressure monitoring during mechanical ventilation.

Continuous renal replacement therapy for safe and adequate voriconazole intravenous treatment: enough reason to be confident?

Correction to: CO2 and O2 removal during continuous veno-venous hemofiltration: a pilot study

Correction to: Chloride content of solutions used for regional citrate anticoagulation might be responsible for blunting correction of metabolic acidosis during continuous venovenous hemofiltration

Dexmedetomidine: the first new kid on the block for preventing cardiac surgery-associated acute kidney injury?

Diffuse alveolar haemorrhage with predominant upper lung lobe involvement associated with congestive heart failure: a case series.

Do Statins Induce or Protect from Acute Kidney Injury and Chronic Kidney Disease: An Update Review in 2018

Dosing adjuvant vitamin C in critically ill patients undergoing continuous renal replacement therapy: We are not there yet!

Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002.

Editorial over the Many Faces of Vitamin D in Chronic Kidney Disease: from Mineral to Immune-Inflammatory Modulator

Efficacy of polymyxin B hemoperfusion in and beyond septic shock: is an "endotoxin severity score" needed?

Efficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients-a randomized clinical trial

Eliminating endotoxin by polymyxin B hemoperfusion and/or continuous renal replacement therapy: should the focus be on timing, dosing, and type of renal epuration?

Energy expenditure of patients on ECMO: A prospective pilot study

Eravacycline for treatment of complicated intra-abdominal infections: the fire is not ignited!

Evolution of Vascular Access and Anticoagulation

Facing acid-base disorders in the third millennium - the Stewart approach revisited.

Feasibility of cerebral magnetic resonance imaging in patients with externalised spinal cord stimulator.

Fondaparinux: another potential treatment for heparin-induced thrombocytopenia type II?

Fulminant myocarditis in children. Continuous renal replacement therapy to the rescue?

Hemoadsorption therapy in the critically ill: solid base but clinical haze

Heparin-binding protein in sepsis: player! predictor! positioning?

High-frequency percussive ventilation in acute respiratory distress syndrome: knocking at the door but can it be let in?

Higher colistin dose during continuous renal replacement therapy: look before leaping!

How to deal with severe acute pancreatitis in the critically ill

Hyperchloremia-associated acute chronic kidney injury: beware of confounders!

Immunoadsorption versus therapeutic plasma exchange. Will fibrinogen make the difference?

Impact of maintenance, resuscitation and unintended fluid therapy on global fluid load after elective coronary artery bypass surgery

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project.

Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

Intertwining extracorporeal membrane oxygenation and continuous renal replacement therapy: sense or nonsense?

Is neutrophil gelatinase-associated lipocalin unaffected by convective continuous renal replacement therapy? Definitely … maybe.

Lactate: the Black Peter in high-risk gastrointestinal surgery patients.

Look before leaping into combining extracorporeal techniques to improve oxygenation!

Measuring resting energy expenditure during extracorporeal membrane oxygenation: preliminary clinical experience with a proposed theoretical model

Meropenem therapy in extracorporeal membrane oxygenation patients: an ongoing pharmacokinetic challenge

Metabolic and coagulation effects of citrate: down to the last detail!

Nebulized colistin for treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: we still need to straighten out the dose!

Neutrophil gelatinase-associated lipocalin elimination by renal replacement therapy: minding the membrane!

New generation indirect calorimeters for measuring energy expenditure in the critically ill: a rampant or reticent revolution?

Nobiletin: A Citrus Isolate to Make Sepsis Less Sour.

Normal saline as resuscitation fluid in critically ill patients: not dead yet!

Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial

Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?

Optimizing citrate dose for regional anticoagulation in continuous renal replacement therapy: measuring citrate concentrations instead of ionized calcium?

Optimizing micafungin dosing in critically ill patients: what about extracorporeal therapies?

Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?

Outcome Prediction of Acute Kidney Injury Biomarkers at Initiation of Dialysis in Critical Units

Oxidative stress markers and septic acute kidney injury: Novel research avenue or road to nowhere?

Passive leg raising test with minimally invasive monitoring: the way forward for guiding septic shock resuscitation?

Pentraxin-3 to better delineate necrotizing soft tissue infection: not really!

Peri-operative fluid strategy and post-operative acute kidney injury in cardiac surgery patients: any role for pre-operative statin therapy?