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List of works by Makoto Nakakido

Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface

scientific article published on 27 December 2018

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex

scientific article published on 27 January 2014

An epitope-directed antibody affinity maturation system utilizing mammalian cell survival as readout

scientific article published on 29 March 2019

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

scientific article published on 14 March 2016

Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes.

scientific article

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.

scientific article published on 9 December 2014

Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1

scientific article published on 15 August 2018

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.

scientific article published on April 2015

Exploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations

scientific article published on 14 March 2019

Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18

scientific article published on 04 January 2019

Improvement of antibody affinity by introduction of basic amino acid residues into the framework region

scientific article published on 14 July 2018

Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody

scientific article published on 01 July 2018

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin

scientific article published on 19 April 2018

PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.

scientific article

PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

scientific article published on 3 September 2015

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.

scientific article published on 06 July 2016

Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery.

scientific article published on 9 January 2018

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

scientific article published on 16 September 2014

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

scientific journal article

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.

scientific article published on 8 September 2016

Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody

scientific article published on 18 August 2018

Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.

scientific article published on 13 January 2015

Structure-based analysis reveals hydration changes induced by arginine hydrochloride.

scientific article

The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop

scientific article

The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation

scientific article published on 29 April 2014

Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1.

scientific article

Two Secreted Proteoglycans, Activators of Urothelial Cell-Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression

scientific article published on 13 November 2020

Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody

scientific article published on 05 July 2018

WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.

scientific article published on 3 October 2014

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