Search filters

List of works by Gavin J Churchyard

"Proof-of-concept" evaluation of an automated sputum smear microscopy system for tuberculosis diagnosis

scientific article

"That is why I stopped the ART": patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme

scientific article

A Short Regimen for Rifampin-Resistant Tuberculosis

scientific article published on 13 March 2019

A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

scientific article published on 01 April 2014

A clinical scoring system to prioritise investigation for tuberculosis among adults attending HIV clinics in South Africa

scientific article

A cluster randomised trial to evaluate the effect of optimising TB/HIV integration on patient level outcomes: the "merge" trial protocol.

scientific article published on 12 October 2014

A novel HIV treatment model using private practitioners in South Africa

scientific article published on March 2012

A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204)

scientific article (publication date: 2011)

A stratified approach to tuberculosis treatment

scientific article published on 01 November 2018

A trial of mass isoniazid preventive therapy for tuberculosis control

scientific article published on January 2014

Accelerating progress towards tuberculosis elimination: the need for combination treatment and prevention

scientific article

Achieving the health Millennium Development Goals for South Africa: challenges and priorities

scientific article published on 24 August 2009

Advances in immunotherapy for tuberculosis treatment

scientific article published on December 2009

Adverse events with isoniazid preventive therapy: experience from a large trial

scientific article published on November 2010

An evaluation framework for new tests that predict progression from tuberculosis infection to clinical disease

scientific article published on 25 October 2018

An intervention to optimise the delivery of integrated tuberculosis and HIV services at primary care clinics: results of the MERGE cluster randomised trial

article

Antiretroviral therapy using zidovudine, lamivudine, and efavirenz in South Africa: tolerability and clinical events

scientific article published on January 2008

Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources

scientific article published on July 2010

Antiviral Innate Immune Activation in HIV-Infected Adults Negatively Affects H1/IC31-Induced Vaccine-Specific Memory CD4+ T Cells

scientific article published on 29 April 2015

Application of provincial data in mathematical modelling to inform sub-national tuberculosis program decision-making in South Africa

scientific article published in PLoS ONE

Applying ethical principles to international community-based research: a case study from the Consortium to Respond Effectively to the AIDS-TB Epidemic (CREATE) .

scientific article published on May 2014

Aspiring to zero tuberculosis deaths among southern Africa's miners: is there a way forward?

scientific article published on January 2013

Association of isoniazid preventive therapy with lower early mortality in individuals on antiretroviral therapy in a workplace programme

scientific article

Attitudes to directly observed antiretroviral treatment in a workplace HIV care programme in South Africa

scientific article published on 13 June 2007

Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa

scientific article

Barriers to implementation of isoniazid preventive therapy in HIV clinics: a qualitative study

scientific article published on November 2010

Brief Report: The Effect of Antiretroviral Therapy and CD4 Count on Markers of Infectiousness in HIV-Associated Tuberculosis

scientific article published on September 2015

Building a tuberculosis-free world: The Lancet Commission on tuberculosis

scientific article published on 20 March 2019

Business and AIDS: sectoral challenges and opportunities

scientific article

Changing predictors of mortality over time from cART start: implications for care

scientific article

Chronic hepatitis B increases mortality and complexity among HIV-coinfected patients in South Africa: a cohort study.

scientific article published on 17 March 2016

Clinic-level factors influencing patient outcomes on antiretroviral therapy in primary health clinics in South Africa

scientific article

Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study

scientific article published on 28 May 2015

Comparison of tenofovir, zidovudine, or stavudine as part of first-line antiretroviral therapy in a resource-limited-setting: a cohort study

scientific article

Comparison of two active case-finding strategies for community-based diagnosis of symptomatic smear-positive tuberculosis and control of infectious tuberculosis in Harare, Zimbabwe (DETECTB): a cluster-randomised trial

scientific article

Connectivity of diagnostic technologies: improving surveillance and accelerating tuberculosis elimination.

scientific article published on August 2016

Contrasting predictors of poor antiretroviral therapy outcomes in two South African HIV programmes: a cohort study

scientific article

Contrasting reasons for discontinuation of antiretroviral therapy in workplace and public-sector HIV programs in South Africa

scientific article

Controlling latent TB tuberculosis infection in high-burden countries: A neglected strategy to end TB

article published in 2019

Correction to: Small contribution of gold mines to the ongoing tuberculosis epidemic in South Africa: a modeling-based study

scholarly article published in BMC Medicine

Cost-effectiveness and resource implications of aggressive action on tuberculosis in China, India, and South Africa: a combined analysis of nine models

scientific article published on 6 October 2016

Cost-effectiveness of Xpert MTB/RIF for tuberculosis diagnosis in South Africa: a real-world cost analysis and economic evaluation.

scientific article

Cost-effectiveness of preventive therapy for tuberculosis with isoniazid and rifapentine versus isoniazid alone in high-burden settings

scientific article

Cytomegalovirus viremia as a risk factor for mortality prior to antiretroviral therapy among HIV-infected gold miners in South Africa

scientific article (publication date: 2011)

Designing an adaptive phase II/III trial to evaluate efficacy, safety and immune correlates of new TB vaccines in young adults and adolescents.

scientific article published on 23 December 2012

Detection and Quantification of Differentially Culturable Tubercle Bacteria in Sputum from Patients with Tuberculosis.

scientific article published on 7 July 2016

Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies

scientific article (publication date: 18 January 2011)

Diagnostic Accuracy of Lateral Flow Urine LAM Assay for TB Screening of Adults with Advanced Immunosuppression Attending Routine HIV Care in South Africa

scientific article

Diagnostic accuracy of a urine lipoarabinomannan enzyme-linked immunosorbent assay for screening ambulatory HIV-infected persons for tuberculosis

scientific article

Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization

scientific article published in January 2010

Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection.

scientific article published on 23 February 2018

Does tuberculosis increase HIV load?

scientific article published on 30 September 2004

Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: a cohort study

scientific article

Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials

scientific article published on 2 September 2015

Effect of routine isoniazid preventive therapy on tuberculosis incidence among HIV-infected men in South Africa: a novel randomized incremental recruitment study

scientific article published on June 2005

Efficacy of secondary isoniazid preventive therapy among HIV-infected Southern Africans: time to change policy?

scientific article published in September 2003

Eligibility for isoniazid preventive therapy in South African gold mines

scientific article

Empiric tuberculosis treatment in South African primary health care facilities - for whom, where, when and why: Implications for the development of tuberculosis diagnostic tests

scientific article

Epidemiologic studies and novel clinical research approaches that impact TB vaccine development

scientific article published on 11 June 2016

Evaluation of a point-of-care tuberculosis test-and-treat algorithm on early mortality in people with HIV accessing antiretroviral therapy (TB Fast Track study): study protocol for a cluster randomised controlled trial

scientific article

Evaluation of a workplace HIV treatment programme in South Africa

scientific article published on July 2007

Evaluation of the WHO criteria for antiretroviral treatment failure among adults in South Africa

scientific article published on October 2008

Evidence-informed policy making at country level: lessons learned from the South African Tuberculosis Think Tank.

scientific article

Factors influencing uptake of HIV care and treatment among children in South Africa - a qualitative study of caregivers and clinic staff.

scientific article published on September 2010

Feasibility of achieving the 2025 WHO global tuberculosis targets in South Africa, China, and India: a combined analysis of 11 mathematical models.

scientific article published on 6 October 2016

Four models of HIV counseling and testing: utilization and test results in South Africa

scientific article

Genotype MTBDRplus for direct detection of Mycobacterium tuberculosis and drug resistance in strains from gold miners in South Africa

scientific article published on 11 January 2012

Guidance for Studies Evaluating the Accuracy of Sputum-Based Tests to Diagnose Tuberculosis

scientific article published on 01 October 2019

HIV infection and chronic chest disease as risk factors for bacterial pneumonia: a case-control study

scientific article published in July 2003

HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response

scientific article

HIV infection does not affect active case finding of tuberculosis in South African gold miners

scientific article published on 10 September 2009

HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa

scientific article published on August 2009

HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

scientific article published on 30 July 2015

Hepatitis B virus infection and response to antiretroviral therapy (ART) in a South African ART program

scientific article published on December 2008

Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B.

scientific article

High tuberculosis prevalence in a South African prison: the need for routine tuberculosis screening

scientific article published on 30 January 2014

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis

scientific article

Household HIV Testing Uptake among Contacts of TB Patients in South Africa

scientific article

Household point of care CD4 testing and isoniazid preventive therapy initiation in a household TB contact tracing programme in two districts of South Africa

scientific article published on 2 March 2018

Human immunodeficiency virus and the prevalence of undiagnosed tuberculosis in African gold miners

scientific article published on 10 June 2004

Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

scientific article published in September 2018

Impact of Targeted Tuberculosis Vaccination Among a Mining Population in South Africa: A Model-Based Study

scientific article published in December 2017

Impact of reduced hospitalisation on the cost of treatment for drug-resistant tuberculosis in South Africa.

scientific article published on February 2015

Implementing a large-scale systematic tuberculosis screening program in correctional facilities in South Africa

scientific article

Incidence of HIV-associated tuberculosis among individuals taking combination antiretroviral therapy: a systematic review and meta-analysis

scientific article

Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners

scientific article

Innovative clinical trial designs to rationalize TB vaccine development

scientific article published on 06 March 2015

Isoniazid preventive therapy for HIV-infected people: evidence to support implementation ⬇️

scientific article published on November 1, 2010

Linkage to care among adults being investigated for tuberculosis in South Africa: pilot study of a case manager intervention.

scientific article published on 24 May 2018

Low haemoglobin predicts early mortality among adults starting antiretroviral therapy in an HIV care programme in South Africa: a cohort study

scientific article

Lung function loss in relation to silica dust exposure in South African gold miners

article

Measuring mortality due to HIV-associated tuberculosis among adults in South Africa: Comparing verbal autopsy, minimally-invasive autopsy, and research data

scientific article

Missed Opportunities for TB Investigation in Primary Care Clinics in South Africa: Experience from the XTEND Trial.

scientific article published on 18 September 2015

Molecular characterisation of clinical and environmental isolates of Mycobacterium kansasii isolates from South African gold mines

scientific article published on March 2015

Molecular epidemiology of Mycobacterium tuberculosis among South African gold miners

scientific article

Morbidity and mortality in South African gold miners: impact of untreated disease due to human immunodeficiency virus.

scientific article published on 5 April 2002

Mortality associated with delays between clinic entry and ART initiation in resource-limited settings: results of a transition-state model

scientific article published on May 2013

Opportunities afforded by new drugs for tuberculosis

scientific article published on 01 June 2010

Outcomes following virological failure and predictors of switching to second-line antiretroviral therapy in a South African treatment program

scientific article

Outcomes of on-site antiretroviral therapy provision in a South African correctional facility

scientific article published on 4 May 2015

P13-05. Factors associated with pregnancy during the HVTN 503/Phambili trial, a phase IIB HIV trial of the Merck Ad-5 multi-clade HIV vaccine

article

P14-02. Social impact events in Phambili, the first phase 2B HIV vaccine trial in South Africa.

scientific article

P15-08. Did unblinding affect HIV risk behaviour and risk perception in the HVTN503/Phambili study?

article

P15-13. HVTN 503(Phambili) trial discontinuation of enrolment/vaccination: the impact on trial participant attitudes to vaccine trials and scientific research.

scientific article published on 22 October 2009

Pan-tuberculosis regimens: an argument for.

scientific article

Patient costs incurred by people living with HIV/AIDS prior to ART initiation in primary healthcare facilities in Gauteng, South Africa

article

Performance characteristics of the Cepheid Xpert MTB/RIF test in a tuberculosis prevalence survey

scientific article

Performance of a Novel Algorithm Using Automated Digital Microscopy for Diagnosing Tuberculosis

scientific article published on June 2015

Performance of verbal autopsy methods in estimating HIV-associated mortality among adults in South Africa

article

Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners

scientific article published in March 2002

Pooling sputum from multiple individuals for Xpert® MTB/RIF testing: a strategy for screening high-risk populations.

scientific article published in January 2015

Pregnancy incidence and correlates during the HVTN 503 Phambili HIV vaccine trial conducted among South African women

scientific article

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model

scientific article

Provider-initiated symptom screening for tuberculosis in Zimbabwe: diagnostic value and the effect of HIV status

scientific article

Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study

scientific article

Recurrent tuberculosis: relapse, reinfection, and HIV.

scientific article

Reducing mortality with cotrimoxazole preventive therapy at initiation of antiretroviral therapy in South Africa

scientific article

Regarding the effect of cured tuberculosis disease on longevity.

scientific article

Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?

scientific article published in November 2017

Resistance to tenofovir-based regimens during treatment failure of subtype C HIV-1 in South Africa

scientific article

Risk factors for poor virological outcome at 12 months in a workplace-based antiretroviral therapy programme in South Africa: a cohort study

scientific article

Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

scientific article

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial

scientific article

Safety, tolerability, and immunogenicity of the novel antituberculous vaccine RUTI: randomized, placebo-controlled phase II clinical trial in patients with latent tuberculosis infection.

scientific article

Second-line antiretroviral therapy in a workplace and community-based treatment programme in South Africa: determinants of virological outcome

scientific article

Small contribution of gold mines to the ongoing tuberculosis epidemic in South Africa: a modeling-based study

scientific article published on 12 April 2018

Spectrum of non-tuberculous mycobacteria identified using standard biochemical testing vs. 16S sequencing.

scientific article

Stable incidence rates of tuberculosis (TB) among human immunodeficiency virus (HIV)-negative South African gold miners during a decade of epidemic HIV-associated TB.

scientific article published on 03 October 2003

Strategies to Accelerate HIV Care and Antiretroviral Therapy Initiation After HIV Diagnosis: A Randomized Trial

scientific article published on 26 April 2017

Successes, challenges and lessons from a novel deployment of Xpert(®) MTB/RIF at a major South African public event [Short Communication].

scientific article published in April 2014

Symptom and chest radiographic screening for infectious tuberculosis prior to starting isoniazid preventive therapy: yield and proportion missed at screening ⬇️

scientific article published on November 1, 2010

Target regimen profiles for treatment of tuberculosis: a WHO document.

scientific article

The HVTN503/Phambili HIV vaccine trial: a comparison of younger and older participants

scientific article published on 08 October 2013

The Impact of Company-Level ART Provision to a Mining Workforce in South Africa: A Cost-Benefit Analysis

scientific article published in September 2015

The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.

scientific article published in June 2018

The burden of silicosis, pulmonary tuberculosis and COPD among former Basotho goldminers

scientific article published in September 2008

The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility

scientific article published on 26 May 2015

The diarylquinoline TMC207 for multidrug-resistant tuberculosis

scientific article (publication date: 4 June 2009)

The economic burden of TB diagnosis and treatment in South Africa

scientific article published on 27 January 2015

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

scientific article

The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study

scientific article published on 18 April 2013

The patient costs of care for those with TB and HIV: a cross-sectional study from South Africa.

scientific article

The safety and immunogenicity of an adenovirus type 35-vectored TB vaccine in HIV-infected, BCG-vaccinated adults with CD4(+) T cell counts >350 cells/mm(3).

scientific article published on 17 February 2015

The timing of tuberculosis after isoniazid preventive therapy among gold miners in South Africa: a prospective cohort study

scientific article published on 23 March 2016

Thibela TB: design and methods of a cluster randomised trial of the effect of community-wide isoniazid preventive therapy on tuberculosis amongst gold miners in South Africa

scientific article published on 28 December 2010

Trends in silicosis prevalence and the healthy worker effect among gold miners in South Africa: a prevalence study with follow up of employment status

scientific article published on 18 December 2015

Tuberculosis Infectiousness and Host Susceptibility

scientific article

Tuberculosis active case finding: uptake and diagnostic yield among minibus drivers in urban South Africa

scientific article

Tuberculosis among adults starting antiretroviral therapy in South Africa: the need for routine case finding.

scientific article published on 12 July 2012

Tuberculosis and HIV coinfection: current state of knowledge and research priorities

scientific article published on 01 August 2007

Tuberculosis control in South Africa: successes, challenges and recommendations.

scientific article published on March 2014

Tuberculosis control in South African gold mines: mathematical modeling of a trial of community-wide isoniazid preventive therapy

scientific article

Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment

scientific article

Tuberculosis outcomes and drug susceptibility in individuals exposed to isoniazid preventive therapy in a high HIV prevalence setting

scientific article published on April 2010

Tuberculosis prevention in South Africa

scientific article

Tuberculosis preventive therapy in the era of HIV infection: overview and research priorities

scientific article published on August 2007

Tuberculosis preventive therapy: an underutilised strategy to reduce individual risk of TB and contribute to TB control

scientific article published on 16 April 2014

Tuberculosis vaccines and prevention of infection

scientific article

Twelve-monthly versus six-monthly radiological screening for active case-finding of tuberculosis: a randomised controlled trial

scientific article published on 23 November 2010

Undiagnosed tuberculosis among HIV clinic attendees: association with antiretroviral therapy and implications for intensified case finding, isoniazid preventive therapy, and infection control

scientific article

Use of traditional medicine by HIV-infected individuals in South Africa in the era of antiretroviral therapy

scientific article

Using Top-down and Bottom-up Costing Approaches in LMICs: The Case for Using Both to Assess the Incremental Costs of New Technologies at Scale

scientific article published on 14 January 2016

Using mHealth to improve tuberculosis case identification and treatment initiation in South Africa: Results from a pilot study. ⬇️

scientific article published on 3 July 2018

Verbal autopsy-assigned causes of death among adults being investigated for TB in South Africa

scientific article published on September 2016

Viral suppression following switch to second-line antiretroviral therapy: associations with nucleoside reverse transcriptase inhibitor resistance and subtherapeutic drug concentrations prior to switch

scientific article published on 13 August 2013

Viremia, resuppression, and time to resistance in human immunodeficiency virus (HIV) subtype C during first-line antiretroviral therapy in South Africa

scientific article published on December 2009

What We Know About Tuberculosis Transmission: An Overview

scientific article published in November 2017

What is thwarting tuberculosis prevention in high-burden settings?

scientific article published in July 2011

Why have trials of isoniazid preventive therapy among people with HIV infection not demonstrated an effect on mortality?: did close examination of the trees obscure our view of the wood?

scientific article published on November 2010

Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF.

scientific article published on August 2015

Paulina is supported by:

About Paulina

Help