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List of works by Jennifer Howes

C-terminal Mutations Destabilize SIL1/BAP and Can Cause Marinesco-Sjögren Syndrome ⬇️

scientific article published on January 4, 2012

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

scientific article published on 30 June 2008

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

scientific article published on 28 September 2018

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

scientific article published in June 2018

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS

scientific article published on 08 August 2018

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

scientific article published on 11 February 2018

Sil1, a nucleotide exchange factor for BiP, is not required for antibody assembly or secretion

scientific article

Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses

scientific article published on 18 February 2019

Small molecule-mediated activation of RAS elicits biphasic modulation of phospho ERK levels that are regulated through negative feedback on SOS1.

scientific article published on 13 February 2018

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