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List of works by Daisuke Saigusa

A novel and sensitive assay for heme oxygenase activity

scientific article published on 29 July 2015

A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways

scientific article

Asymmetric Dimethylarginine Contributes to the Impaired Response to Erythropoietin in CKD-Anemia.

scientific article published on 9 June 2017

Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways

scientific article

Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model.

scientific article published on 22 November 2017

Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

scientific article published on 28 June 2019

Conformational change in transfer RNA is an early indicator of acute cellular damage

scientific article

Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate.

scientific article published on 15 October 2016

Detection of novel metabolite for roxadustat doping by global metabolomics

scientific article published on 01 June 2018

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery

scientific article

Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals.

scientific article published in December 2017

Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer.

scientific article published on 21 November 2017

Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation

scientific article published on 28 September 2014

Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation

scientific article published on 08 September 2018

Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation

scientific article published on 25 August 2018

Functional characterization of CYP2B6 allelic variants in demethylation of antimalarial artemether

scientific article published on 11 July 2011

Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare

article

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

scientific article published on 23 April 2019

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

scientific article published on 11 May 2011

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension

scientific article published on 14 June 2019

Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry ima

scientific article published on 06 November 2019

Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

scientific article published on 28 December 2017

Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.

scientific article published on 17 February 2016

Inter-Laboratory Comparison of Metabolite Measurements for Metabolomics Data Integration

scientific article published on 31 October 2019

Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia

scientific article published on 19 May 2018

Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A

scientific article published on 01 April 2019

Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity

scientific article

Liver Zonation Index of Drug Transporter and Metabolizing Enzyme Protein Expressions in Mouse Liver Acinus

scientific article published on 05 March 2018

Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy

scientific article published on 19 February 2019

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

scientific article

Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging

scientific article published on 03 August 2018

Metabolomic changes in the mouse retina after optic nerve injury

scientific article published in Scientific Reports

Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.

scientific article

Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases.

scientific article published on January 2015

Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage

scientific article published on 25 November 2015

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.

scientific article published on 28 March 2016

Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.

scientific article published on 20 May 2009

Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

scientific article published on 10 June 2008

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.

scientific article

Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice

scientific article published on 01 April 2019

Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project

scientific article published on 27 April 2018

Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.

scientific article published on 21 January 2014

Proteomics and metabolomics as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument or hype?

scientific article published on 18 February 2014

Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS

scientific article

Simultaneous determination of guanidinosuccinic acid and guanidinoacetic acid in urine using high performance liquid chromatography/tandem mass spectrometry ⬇️

scientific article published on August 13, 2010

Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.

scientific article

Simultaneous quantitative analysis of uremic toxins by LC-MS/MS with a reversed-phase/cation-exchange/anion-exchange tri-modal mixed-mode column.

scientific article published on 5 October 2017

Structural Determination of Lysosphingomyelin-509 and Discovery of Novel Class Lipids from Patients with Niemann-Pick Disease Type C

scientific article published on 10 October 2019

The structural origin of metabolic quantitative diversity.

scientific article published on 16 August 2016

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.

scientific article published on 20 October 2016

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

scientific article published on 14 October 2013

Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma

scientific article published on 24 January 2019

Vitamin B3 Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth.

scientific article published in January 2018

jMorp: Japanese Multi Omics Reference Panel

scientific article published on 24 October 2017

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