List of works - Patricia Steeg

A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

scientific article

A HER2 Antibody Drug Conjugate Controls Growth of Breast Cancer Brain Metastases in Hematogenous Xenograft Models, with Heterogeneous Blood-Tumor Barrier Penetration Unlinked to a Passive Marker

scientific article published on 09 May 2020

A framework for the development of effective anti-metastatic agents

scientific article published on 01 March 2019

A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice

scientific article published on 9 January 2013

Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.

scientific article published in April 2007

Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility

scientific article published on February 2008

Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer

scientific article published on 31 May 2016

Altered gene and protein expression by Nm23-H1 in metastasis suppression

scientific article

An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis

scientific article

Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

scientific article

Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis

scientific article published on 30 August 2015

Basic and translational advances in cancer metastasis: Nm23.

scientific article

Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines

scientific article published on 08 July 2020

Brain metastases as preventive and therapeutic targets ⬇️

scientific article published on 07 April 2011

Brain metastases of breast cancer.

scientific article

Breast Cancer Metastasis: Challenges and Opportunities

scientific article published on 26 May 2009

Breast cancer metastasis to the central nervous system

scientific article

Breast cancer metastasis: issues for the personalization of its prevention and treatment

scientific article published on 26 July 2013

CELL BIOLOGY AND SIGNALING

CNS metastases in breast cancer: old challenge, new frontiers

scientific article published on December 2013

Cancer metastasis as a therapeutic target

scientific article published on 20 March 2010

Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study

scientific article

Caveolin-1 Upregulation Mediates Suppression of Primary Breast Tumor Growth and Brain Metastases by Stat3 Inhibition ⬇️

scientific article published on May 27, 2011

Clinical-translational strategies for the elevation of Nm23-H1 metastasis suppressor gene expression

scientific article

Collapsin response mediator protein-1: a lung cancer invasion suppressor gene with nerve

scientific article published on 01 September 2001

Cyclin D1 in breast premalignancy and early breast cancer: implications for prevention and treatment

scientific article

Cyclin D1 overexpression in a model of human breast premalignancy: preferential stimulation of anchorage-independent but not anchorage-dependent growth is associated with increased cdk2 activity

scientific article

Cyclins and breast cancer

scientific article

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer

scientific article

DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer

scientific article published on 27 December 2011

Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor gene expression in metastatic human breast carcinoma cells: new uses for old compounds.

scientific article published on September 2003

Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer

scientific article published on 21 August 2012

Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain

scientific article published on 29 July 2008

Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.

scientific article published on October 2010

Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases

scientific article published on 22 February 2019

Expedition Inspiration Fund for Breast Cancer Research Meeting 2003.

scientific article

Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain

scientific article

Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer ⬇️

scientific article published on September 9, 2010

Histidine kinases and histidine phosphorylated proteins in mammalian cell biology, signal transduction and cancer

scientific article

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines

scientific article published on 03 August 2014

In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide

scientific article published on February 2008

In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain

scientific article published in November 2006

In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach.

scientific article published in November 2011

In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T.

scientific article

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain ⬇️

scientific article published on September 21, 2011

Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro ⬇️

scientific article published on 01 July 1997

Inhibition of signal transduction by the nm23 metastasis suppressor: possible mechanisms

scientific article

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis

scientific article

Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene ⬇️

scientific article published on December 1, 2012

Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.

scientific article

Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.

scientific article

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines

scientific article published on January 2002

Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma

scientific article

Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer

scientific article

Metastasis Suppressor Genes: Basic Biology and Potential Clinical Use ⬇️

scientific article published on April 1, 2003

Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis

scientific article published on 16 July 2019

Metastasis suppressors alter the signal transduction of cancer cells

scientific article

Metastasis: a therapeutic target for cancer

scientific article

Molecular analysis of premalignant and carcinoma in situ lesions of the human breast

scientific article published on September 1996

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis

scientific article

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

scientific article

New insights into the tumor metastatic process revealed by gene expression profiling

scientific article

Nm23-H1 homologs suppress tumor cell motility and anchorage independent growth

scientific article published on 5 December 2007

Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells

scientific article

Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway

scientific article

Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.

scientific article published on December 2007

Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.

scientific article published on August 2007

Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis

scientific article

Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

scientific article

Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage

scientific article published on January 2012

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model

scientific article published on 3 September 2013

Pazopanib Inhibits the Activation of PDGFRβ-Expressing Astrocytes in the Brain Metastatic Microenvironment of Breast Cancer Cells ⬇️

scientific article published on April 12, 2013

Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2+ Breast Cancer Brain Metastasis ⬇️

scientific article published on November 16, 2010

Perspectives on classic article: metastasis suppressor genes

scientific article published on March 2004

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

scientific article

Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients.

scientific article

Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner

scientific article

Protein–protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1 ⬇️

scientific article published on June 29, 2011

Proteomic approaches to the diagnosis, treatment, and monitoring of cancer

scientific article

Proteomics of human breast ductal carcinoma in situ.

scientific article

Quantitative protein network monitoring in response to DNA damage

scientific article

Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells

scientific article published on 22 June 2006

Radiation and the Apo2L/TRAIL apoptotic pathway preferentially inhibit the colonization of premalignant human breast cells overexpressing cyclin D1

scientific article published on 01 May 2000

Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases

scientific article published in Nature Communications

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

scientific article published on 23 July 2008

SCDT-11. ASTROCYTIC S1P3 SIGNALING MODULATES BLOOD-TUMOR BARRIER PERMEABILITY IN BRAIN METASTASES

SCDT-12. STUDY OF ROLE OF ASTROCYTIC S1P3 IN REGULATING BLOOD-BRAIN/TUMOR BARRIER PERMEABILITY

TMIC-19. ASTROCYTIC S1P3 SIGNALING MODULATES BLOOD-TUMOR BARRIER PERMEABILITY IN BRAIN METASTASES

scientific article published on 6 November 2017

TMIC-34. STUDY OF ROLE OF ASTROCYTIC S1P3 IN REGULATING BLOOD-BRAIN/TUMOR BARRIER PERMEABILITY

TMIC-37. THE MICROENVIRONMENT OF A YOUNGER BRAIN IS MORE PERMISSIVE FOR BREAST CANCER BRAIN METASTASIS

TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells

scientific article published on 23 May 2012

Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases

scientific article published on 09 April 2020

The B-Raf Status of Tumor Cells May Be a Significant Determinant of Both Antitumor and Anti-Angiogenic Effects of Pazopanib in Xenograft Tumor Models ⬇️

scientific article published on October 5, 2011

The Nm23-H1 metastasis suppressor as a translational target

scientific article

The biology of metastasis to a sanctuary site

scientific article published on March 2007

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

scientific article published on 21 October 2021

The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model

scientific article

The role of metastasis suppressor genes in metastatic dormancy

scientific article

The small heat shock protein hsp27 increases invasiveness but decreases motility of breast cancer cells

scientific article published on January 1, 1997

The state of melanoma: challenges and opportunities

scientific article

Therapeutics for Brain Metastases, v3.

scientific article published on 10 October 2016

Toward a drug development path that targets metastatic progression in osteosarcoma.

scientific article

Translational approaches using metastasis suppressor genes

scientific article published on August 2006

Translational research in brain metastasis is identifying molecular pathways that may lead to the development of new therapeutic strategies

scientific article

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

scientific article published on 04 November 2019

Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer

scientific article

Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer

scientific article published on 19 August 2016

Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts

scientific article

Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks

scientific article published on 29 September 2009

List of works by Patricia Steeg

A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

A HER2 Antibody Drug Conjugate Controls Growth of Breast Cancer Brain Metastases in Hematogenous Xenograft Models, with Heterogeneous Blood-Tumor Barrier Penetration Unlinked to a Passive Marker

A framework for the development of effective anti-metastatic agents

A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice

Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.

Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility

Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer

Altered gene and protein expression by Nm23-H1 in metastasis suppression

An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis

Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis

Basic and translational advances in cancer metastasis: Nm23.

Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines

Brain metastases as preventive and therapeutic targets ⬇️

Brain metastases of breast cancer.

Breast Cancer Metastasis: Challenges and Opportunities

Breast cancer metastasis to the central nervous system

Breast cancer metastasis: issues for the personalization of its prevention and treatment

CELL BIOLOGY AND SIGNALING

CNS metastases in breast cancer: old challenge, new frontiers

Cancer metastasis as a therapeutic target

Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study

Caveolin-1 Upregulation Mediates Suppression of Primary Breast Tumor Growth and Brain Metastases by Stat3 Inhibition ⬇️

Clinical-translational strategies for the elevation of Nm23-H1 metastasis suppressor gene expression

Collapsin response mediator protein-1: a lung cancer invasion suppressor gene with nerve

Cyclin D1 in breast premalignancy and early breast cancer: implications for prevention and treatment

Cyclin D1 overexpression in a model of human breast premalignancy: preferential stimulation of anchorage-independent but not anchorage-dependent growth is associated with increased cdk2 activity

Cyclins and breast cancer

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer

DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer

Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor gene expression in metastatic human breast carcinoma cells: new uses for old compounds.

Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer

Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain

Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.

Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases

Expedition Inspiration Fund for Breast Cancer Research Meeting 2003.

Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain

Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer ⬇️

Histidine kinases and histidine phosphorylated proteins in mammalian cell biology, signal transduction and cancer

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines

In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide

In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain

In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach.

In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T.

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain ⬇️

Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro ⬇️

Inhibition of signal transduction by the nm23 metastasis suppressor: possible mechanisms

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis

Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene ⬇️

Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.

Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines

Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma

Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer

Metastasis Suppressor Genes: Basic Biology and Potential Clinical Use ⬇️

Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis

Metastasis suppressors alter the signal transduction of cancer cells

Metastasis: a therapeutic target for cancer

Molecular analysis of premalignant and carcinoma in situ lesions of the human breast

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

New insights into the tumor metastatic process revealed by gene expression profiling

Nm23-H1 homologs suppress tumor cell motility and anchorage independent growth

Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells

Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway

Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.

Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.

Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis

Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model

Pazopanib Inhibits the Activation of PDGFRβ-Expressing Astrocytes in the Brain Metastatic Microenvironment of Breast Cancer Cells ⬇️

Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2+ Breast Cancer Brain Metastasis ⬇️

Perspectives on classic article: metastasis suppressor genes

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients.

Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner

Protein–protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1 ⬇️