List of works by Geert van Loo

A 96-well flow cytometric screening assay for detecting in vitro phospholipidosis-induction in the drug discovery phase.

scientific article

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

scientific article published in May 2003

A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions

scientific article

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

scientific article published on 18 December 2018

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

scientific article published on 14 August 2011

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

scientific article

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

scientific article published on 27 January 2016

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes

scientific article

A20 Restrains Thymic Regulatory T Cell Development.

scientific article published on 25 August 2017

A20 and CYLD do not share significant overlapping functions during B cell development and activation

scientific article published on 21 September 2012

A20 and Cell Death-driven Inflammation

scientific article published on 30 March 2020

A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity

scientific article published on 02 January 2020

A20 controls intestinal homeostasis through cell-specific activities

scientific article published on 30 September 2014

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

scientific article published on 23 May 2018

A20 deletion in T cells modulates acute graft-versus-host disease in mice

scientific article published on 22 August 2017

A20 in inflammation and autoimmunity

scientific article

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis

scientific article published on 22 August 2016

A20 phosphorylation controls A20 function

scientific article published on 01 October 2019

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

scientific article published on 13 May 2019

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.

scientific article

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

scientific article published on 18 September 2019

A20-deficient mast cells exacerbate inflammatory responses in vivo

scientific article published on 14 January 2014

A20: attractive without showing cleavage

scientific article published on 30 May 2014

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

scientific article published on 20 July 2022

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway

scientific article published on 16 December 2022

Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

scientific article published on 13 January 2017

Adipose tissue macrophages and their polarization in health and obesity

scientific article published on 05 March 2018

An Unusual Location of Extraosseous Ewing's Sarcoma.

scientific article published on 30 May 2013

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis.

scientific article

Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis

scientific article

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.

scientific article published on February 2005

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

scientific article published in March 2018

Author Correction: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

scientific article published on 01 April 2019

Author Correction: Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

correction of a scholarly article

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

scientific journal article

BACE2 distribution in major brain cell types and identification of novel substrates

scientific article published on 01 January 2018

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

scientific article published on January 2004

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

scientific article published on 10 May 2012

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae

scientific article published in 2019

Cellular Functions of Optineurin in Health and Disease

scientific article

Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis

scientific article published on 30 August 2012

Correction: A20 () Deficiency in Myeloid Cells Protects against Influenza A Virus Infection

Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

scientific article published on 23 January 2020

DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice

scientific article published on 05 August 2020

DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology

scientific article published on 09 July 2019

Death receptor signalling in central nervous system inflammation and demyelination

scientific article published on 13 October 2011

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

scientific article published on 01 February 2007

Development of a sanitary risk index for Salmonella seroprevalence in Belgian pig farms.

scientific article published on 2 May 2008

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals

scientific article published on 03 May 2009

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

scientific article published on 10 December 2003

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

scientific article published on 18 November 2002

El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes

scientific article published on 29 October 2019

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

scientific article

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

scientific article published on 06 July 2011

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

scientific article

Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation

scientific article published on 01 November 2019

Epithelial NEMO links innate immunity to chronic intestinal inflammation

scientific article published in Nature

Expression, biological activities and mechanisms of action of A20 (TNFAIP3).

scientific article published on 03 July 2010

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

scientific article published on 31 July 2011

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

scientific article published on September 2015

Fibrotic enzymes modulate wound-induced skin tumorigenesis

scientific article published on 29 March 2021

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease

scientific article

Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond.

scientific article published on 12 April 2007

House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent

scientific article published on 27 September 2018

IL1β promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin

scientific article published on 23 December 2020

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20

scientific article published on 11 May 2018

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

scientific article published in April 2008

IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system

scientific article

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

scientific article published on 01 December 2020

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

scientific article published on 18 January 2005

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

scientific article published in 2024

Inflammasomes in neuroinflammatory and neurodegenerative diseases.

scientific article

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB.

scientific article published on 22 February 2017

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

scholarly article by Geert van Loo et al published 6 August 2006 in Nature Immunology

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis

scientific article published on 14 August 2018

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

scientific article

MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway.

scientific article published on 12 February 2015

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

scientific article published on 18 December 2018

Mitochondrial intermembrane proteins in cell death

scientific article

NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes

scientific article published on 19 May 2022

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

scientific article published on 22 August 2016

Negative regulation of NF-κB and its involvement in rheumatoid arthritis

scientific article published on 31 May 2011

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

scientific article

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

scientific article published on 24 April 2019

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

scientific article published on 02 September 2013

Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal Viruses

scientific article published on 03 October 2018

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

scientific article published on 01 February 2020

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination

scientific article published on 10 November 2010

Optineurin Functions for Optimal Immunity.

scientific article published on 10 April 2018

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

scientific article published on 17 December 2015

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

scientific article published on 11 February 2013

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

scientific article

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

scientific article published on 23 April 2019

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

scientific article published in September 2014

Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch

scientific article

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.

scientific article published in January 2002

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

scientific article published on 13 February 2019

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

scientific article

TNF-α-induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma

scientific article published on 6 September 2017

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

scientific article published on 25 May 2022

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

scientific article published on 13 October 2011

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine

scientific article published on 15 March 2016

The anti-inflammatory protein TNFAIP3/A20 binds the WD40 domain of ATG16L1 to control the autophagic response, NFKB/NF-κB activation and intestinal homeostasis

scientific article published on 16 June 2019

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

scientific article

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

scientific article published on 28 July 2009

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

scientific article published on 11 July 2019

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.

scientific article published on 30 June 2011

Tnfaip3 expression in pulmonary conventional type 1 Langerin-expressing dendritic cells regulates T helper 2-mediated airway inflammation in mice

scientific article published on 23 April 2020

Toxic proteins released from mitochondria in cell death

scientific article published on April 2004

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

scientific article published on 16 March 2020

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

scientific article published on 28 June 2021

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