List of works - John H Griffin

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

scientific article

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

scientific article published on 31 October 2004

Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor

scientific article published on August 1, 1976

Activated protein C: biased for translation.

scientific article published on 30 March 2015

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

scientific article published on 03 March 2014

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII)

scientific article published on April 1, 1978

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

scientific article

Cytoprotective protein C pathways and implications for stroke and neurological disorders

scientific article published on February 25, 2011

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

scientific article

High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.

scientific article published in August 2005

Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein

scientific article published on October 1, 1977

Protein C anticoagulant and cytoprotective pathways

scientific article published on April 5, 2012

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

scientific article

Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma

scientific article published on March 1, 1978

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.

scientific article

Receptors for high molecular weight kininogen on stimulated washed human platelets

scientific article published on December 18, 1984

3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.

scientific article

Functional recovery after embolic stroke in rodents by activated protein C.

scientific article published in September 2005

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

scientific article

Generation and phenotypic analysis of protein S-deficient mice.

scientific article

The Biochemistry and Pathophysiology of the Contact System of Plasma

scientific article published on January 1, 1982

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

scientific article published on April 2013

Total chemical synthesis of enzymatically active human type II secretory phospholipase A 2

scientific article published on July 22, 1997

Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.

scientific article published on 7 September 2017

Human factor XII (Hageman factor)

scientific article published on 01 January 1976

EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

scientific article published on 2 March 2015

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats

scientific article published on 24 October 2013

Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa–Induced Lung Injury in Mice

scientific article published on January 21, 2011

Cytoprotective-selective activated protein C therapy for ischaemic stroke

scientific article

Molecular assembly in the contact phase of the Hageman factor system

scientific article published on October 1, 1979

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1

scientific article published on 21 February 2013

Binding Site for Blood Coagulation Factor Xa Involving Residues 311–325 in Factor Va

scientific article published on June 12, 1998

A comparision of the abilities of plasma kallikrein, β-factor XIIa, factor XIa and urokinase to activate plasminogen

scientific article published on February 15, 1983

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

scientific article published on 07 February 2013

Recent Advances in The Understanding of Contact Activation Reactions

scientific article published on January 1, 1979

PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke

scientific article published on 17 January 2018

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

scientific article published on 13 April 2017

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

scientific article published on February 3, 2011

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

scientific article

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

scientific article

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity

scientific article published on October 14, 1997

Activated protein C, protease activated receptor 1, and neuroprotection

scientific article published on 04 June 2018

Steric and Electronic Effects, Enantiospecificity, and Reactive Orientation in DNA Binding/Cleaving by Substituted Derivatives of [SalenMnIII]+

scientific article published on August 14, 1996

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

scientific article

Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

scientific article published on 21 January 2016

Inhibition of Prothrombinase by Human Secretory Phospholipase A2 Involves Binding to Factor Xa

scientific article published on September 11, 1998

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke

scientific article

Lisinopril-Induced Lithium Toxicity

scientific article published on 01 January 1991

Involvement of Amino Acid Residues 423–429 of Human Protein S in Binding to C4b-Binding Protein

scientific article published on June 1, 1998

Identification of new inhibitors of protein kinase R guided by statistical modeling

scientific article published on May 13, 2011

List of works by John H Griffin

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor

Activated protein C: biased for translation.

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII)

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

Cytoprotective protein C pathways and implications for stroke and neurological disorders

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.

Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein

Protein C anticoagulant and cytoprotective pathways

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.

Receptors for high molecular weight kininogen on stimulated washed human platelets

3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.

Functional recovery after embolic stroke in rodents by activated protein C.

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

Generation and phenotypic analysis of protein S-deficient mice.

The Biochemistry and Pathophysiology of the Contact System of Plasma

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

Total chemical synthesis of enzymatically active human type II secretory phospholipase A 2

Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.

Human factor XII (Hageman factor)

EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats

Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa–Induced Lung Injury in Mice

Cytoprotective-selective activated protein C therapy for ischaemic stroke

Molecular assembly in the contact phase of the Hageman factor system

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1

Binding Site for Blood Coagulation Factor Xa Involving Residues 311–325 in Factor Va

A comparision of the abilities of plasma kallikrein, β-factor XIIa, factor XIa and urokinase to activate plasminogen

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

Recent Advances in The Understanding of Contact Activation Reactions

PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity

Activated protein C, protease activated receptor 1, and neuroprotection

Steric and Electronic Effects, Enantiospecificity, and Reactive Orientation in DNA Binding/Cleaving by Substituted Derivatives of [SalenMnIII]+

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

Inhibition of Prothrombinase by Human Secretory Phospholipase A2 Involves Binding to Factor Xa

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke

Lisinopril-Induced Lithium Toxicity

Involvement of Amino Acid Residues 423–429 of Human Protein S in Binding to C4b-Binding Protein

Identification of new inhibitors of protein kinase R guided by statistical modeling