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List of works by John H Griffin

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

scientific article

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

scientific article published on 15 January 2019

3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.

scientific article

A comparision of the abilities of plasma kallikrein, β-factor XIIa, factor XIa and urokinase to activate plasminogen ⬇️

scientific article published on February 15, 1983

A conference of crosstalk: the Gordon Research Conference in Bioorganic Chemistry ⬇️

scientific article published on 01 August 1995

Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled? ⬇️

scientific article published on December 1, 1997

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

scientific article published on 26 June 2019

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1

scientific article published on 21 February 2013

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats

scientific article published on 24 October 2013

Activated protein C and PAR1-derived and PAR3-derived peptides are anti-inflammatory by suppressing macrophage NLRP3 inflammasomes

scientific article published on 13 October 2020

Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin

scientific article published on 19 December 2019

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

scientific article published on 13 April 2017

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

scientific article published on 07 August 2017

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

scientific article

Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism

scientific article

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic

scientific article published on May 2016

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

scientific article

Activated protein C, protease activated receptor 1, and neuroprotection

scientific article published on 04 June 2018

Activated protein C: biased for translation.

scientific article published on 30 March 2015

Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis.

scientific article published on 23 April 2016

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data

scientific article

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

scientific article published on April 2013

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.

scientific article

An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C

scientific article

Antibody SPC-54 provides acute in vivo blockage of the murine protein C system.

scientific article published on 4 February 2013

Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

scientific article published on 21 January 2016

Application of nuclear magnetic resonance spectroscopy to proteins

scientific article published on January 1, 1975

Assignment of an exchangeable low-field nitrogen-hydrogen proton resonance of ribonuclease A to the active-site hisitidine-119 ⬇️

scientific article published on May 22, 1973

Binding Site for Blood Coagulation Factor Xa Involving Residues 311–325 in Factor Va ⬇️

scientific article published on June 12, 1998

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

scientific article published on 03 March 2014

COVID-19 hypothesis: Activated protein C for therapy of virus-induced pathologic thromboinflammation

scientific article published on 01 May 2020

Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C.

scientific article published on 15 September 2017

Carbon-13 nuclear magnetic resonance studies of the binding of selectively 13C-enriched oxytocins to the neurophypophyseal protein, bovine neurophysin II

scientific article published on September 20, 1977

Carbon‐13 nuclear magnetic resonance studies on (85% 13C‐enriched Gly9) oxytocin ⬇️

scientific article published on 01 February 1975

Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module ⬇️

scientific article published on August 1, 1998

Cholesterol enhances phospholipid-dependent activated protein C anticoagulant activity.

scientific article published in February 2005

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

scientific article

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke

scientific article

Comment: Fluoxetine Adverse Effects and Drug Interactions ⬇️

scientific article published on 01 November 1991

Competition of activated protein C and urokinase for a heparin‐dependent inhibitor 1 ⬇️

scientific article published on April 1, 1988

Complexes of activated protein C with α1-antitrypsin in normal pregnancy and in severe preeclampsia ⬇️

scientific article published on 01 May 1991

Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.

scientific article published on 7 September 2017

Cytoprotective protein C pathways and implications for stroke and neurological disorders ⬇️

scientific article published on February 25, 2011

Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa–Induced Lung Injury in Mice ⬇️

scientific article published on January 21, 2011

Cytoprotective-selective activated protein C therapy for ischaemic stroke

scientific article

Design of a DNA-programmed plasminogen activator

article

Drug-biomolecule interactions: proton magnetic resonance studies of complex formation between bovine neurophysins and oxytocin at molecular level ⬇️

scientific article published on March 1975

EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

scientific article published on 2 March 2015

Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism.

scientific article published on 09 May 2016

Elevated serum amyloid A is associated with venous thromboembolism.

scientific article

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

scientific article

Enhanced specificity of immunoblotting using radiolabeled antigen overlay: studies of blood coagulation factor XII and prekallikrein in plasma

scientific article published in 1986

Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation

scientific article

Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.

scientific article published on 22 May 2010

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen

scientific article published on 07 January 2019

Functional recovery after embolic stroke in rodents by activated protein C.

scientific article published in September 2005

Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution

scientific article

Generation and phenotypic analysis of protein S-deficient mice.

scientific article

High molecular weight kininogen receptor

scientific article published on January 1, 1992

High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.

scientific article published in August 2005

Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis ⬇️

scientific article published on November 1, 2011

Human factor XII (Hageman factor)

scientific article published on 01 January 1976

Identification of new inhibitors of protein kinase R guided by statistical modeling ⬇️

scientific article published on May 13, 2011

Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa.

scientific article published on 15 October 2015

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

scientific article

Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity.

scientific article published on November 2013

Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux.

scientific article published on 10 October 2012

Inhibition of Prothrombinase by Human Secretory Phospholipase A2 Involves Binding to Factor Xa ⬇️

scientific article published on September 11, 1998

Inhibition of thrombin generation in human plasma by phospholipid transfer protein

scientific article published on 16 July 2015

Involvement of Amino Acid Residues 423–429 of Human Protein S in Binding to C4b-Binding Protein ⬇️

scientific article published on June 1, 1998

Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations.

scientific article published on July 2008

Lisinopril-Induced Lithium Toxicity ⬇️

scientific article published on 01 January 1991

Low level of the plasma sphingolipid, glucosylceramide, is associated with thrombotic diseases.

scientific article published on 23 June 2017

Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.

scientific article published on 11 August 2015

Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor ⬇️

scientific article published on August 1, 1976

Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk.

scientific article published on 20 June 2017

Molecular assembly in the contact phase of the Hageman factor system ⬇️

scientific article published on October 1, 1979

Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombin activation

scientific article published on 03 September 2019

Neuroprotection and vasculoprotection using genetically targeted protease-ligands

scientific article published on 14 March 2019

Novel Blood Coagulation Molecules: Skeletal Muscle Myosin and Cardiac Myosin

scientific article published on 13 September 2020

Novel exomic rare variants associated with venous thrombosis

scientific article published on 30 March 2020

Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme ⬇️

scientific article published on December 31, 1973

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

scientific article published on 07 February 2013

PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke

scientific article published on 17 January 2018

PAR1 regulation of CXLC1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus

scientific article published on 21 December 2020

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

scientific article

Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C.

scientific article published on 10 July 2016

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

scientific article

Protein C anticoagulant and cytoprotective pathways ⬇️

scientific article published on April 5, 2012

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway ⬇️

scientific article published on February 3, 2011

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity ⬇️

scientific article published on October 14, 1997

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va.

scientific article published on 15 July 2016

Recent Advances in The Understanding of Contact Activation Reactions ⬇️

scientific article published on January 1, 1979

Receptors for high molecular weight kininogen on stimulated washed human platelets ⬇️

scientific article published on December 18, 1984

Regulation of immune cell signaling by activated protein C.

scientific article published on 30 March 2018

Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein

scientific article published on October 1, 1977

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII) ⬇️

scientific article published on April 1, 1978

Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding.

scientific article published on 9 March 2016

Skeletal muscle myosin and cardiac myosin attenuate heparin's antithrombin-dependent anticoagulant activity

scientific article published on 11 November 2020

Studies of bovine neurophysin-neurohypophyseal hormone interactions ⬇️

scientific article published on February 21, 1975

Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma ⬇️

scientific article published on March 1, 1978

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

scientific article published on 9 January 2018

The Biochemistry and Pathophysiology of the Contact System of Plasma

scientific article published on January 1, 1982

The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia.

scientific article

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis

scientific article published on 21 August 2019

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

scientific article published on 31 October 2004

Total chemical synthesis of enzymatically active human type II secretory phospholipase A 2 ⬇️

scientific article published on July 22, 1997

Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids.

scientific article published on 23 January 2014

α2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:α2M Levels Are Associated with Venous Thromboembolism.

scientific article published on 15 February 2018

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