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List of works by Raymond Dingledine

2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions

scientific article published on May 2016

2014 Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression

scientific article published on May 2016

2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

scientific article published on May 2016

2014 Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across The Lifespan

scientific article published on May 2016

2014 Epilepsy Benchmarks: Progress and Opportunities

scientific article published on May 2016

5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease

scientific article published on 01 January 2019

A New Approach for Epilepsy

scientific article published on May 2016

A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats

scientific article published on 06 January 2021

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

scientific article

A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis

scientific article published on 11 February 2019

A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

scientific article published on 25 February 2019

A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding

scientific article

A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy

scientific article published on 31 December 2019

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus ⬇️

scientific article published on October 19, 2011

Acetylcholine as an Excitatory and Inhibitory Transmitter in the Mammalian Central Nervous System

scientific article published on January 1, 1979

Ach-evoked excitation of cortical neurones [proceedings] ⬇️

scientific article published on December 1, 1977

Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors

scientific article

Activity of the rat GluR4 promoter in transfected cortical neurons and glia

scientific article

Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus.

scientific article published in October 2002

An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors

scientific article published on 23 April 2020

Astrocytes in the epileptic brain.

scientific article

Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish

scientific article

Avram Goldstein: the founder of molecular pharmacology.

scientific article published on 17 January 2013

Beneficial Outcome of Urethane Treatment Following Status Epilepticus in a Rat Organophosphorus Toxicity Model.

scientific article

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

scientific article

Brain stem stimulation and the acetylcholine-evoked inhibition of neurones in the feline nucleus reticularis thalami ⬇️

scientific article published on September 1, 1977

Calcium dependance of synaptic transmission in the hippocampal slice ⬇️

scientific article published on February 23, 1981

Cancer and virus leads by HTS, chemical design and SEA data mining

scientific article published in January 2009

Candidate drug targets for prevention or modification of epilepsy

scientific article published on 25 August 2014

Characterization of osteopontin expression and function after status epilepticus

scientific article

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

scientific article published on 15 December 2017

Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman

scientific article published on 19 December 2020

Control of feedforward dendritic inhibition by NMDA receptor-dependent spike timing in hippocampal interneurons.

scientific article published in July 2002

Control of glutamate receptor 2 (GluR2) translational initiation by its alternative 3' untranslated regions.

scientific article published on 30 September 2009

Cyclooxygenase-2 in epilepsy.

scientific article

Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus

scientific article

Developing novel treatments for mood disorders: accelerating discovery

scientific journal article

Development of second generation EP2 antagonists with high selectivity

scientific article

Differential Regulation of Synaptic Inputs to Dentate Hilar Border Interneurons by Metabotropic Glutamate Receptors ⬇️

scientific article published on June 1, 1998

Differential dependence on GluR2 expression of three characteristic features of AMPA receptors

scientific article published in December 1997

Direct detection of a single evoked action potential with MRS in Lumbricus terrestris.

scientific article published on 5 July 2011

Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.

scientific article published on July 2013

Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2.

scientific article published on 2 January 2018

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

scientific article published on 27 May 2008

Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF).

scientific article

Distribution of endorphins (peptides with morphine-like pharmacological activity) in pituitary

scientific article published on April 1, 1977

Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures

scientific article published in December 1990

Dual-component miniature excitatory synaptic currents in rat hippocampal CA3 pyramidal neurons ⬇️

scientific article published on July 1, 1992

EP2 Receptor Signaling Regulates Microglia Death.

scientific article published on 25 February 2015

EP2 receptor signaling pathways regulate classical activation of microglia.

scientific article published on 12 February 2013

Effect of synaptic transmission blockade on morphine action in the guinea-pig myenteric plexus ⬇️

scientific article published on January 1, 1976

Effects of narcotic opiates and serotonin on the electrical behavior of neurons in the guinea pig myenteric plexus ⬇️

scientific article published on June 1, 1974

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

scientific article

Epigenetics and epilepsy.

scientific article

Ethylatropine Bromide as a Peripherally Restricted Muscarinic Antagonist.

scientific article

Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet

scientific article

Evidence for naloxone and opiates as GABA antagonists [proceedings] ⬇️

scientific article published on November 1, 1976

Excitatory amino acids: modes of action on hippocampal pyramidal cells

scientific article published on September 1, 1983

Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system

scientific article

GABAergic inhibition and the induction of spontaneous epileptiform activity by low chloride and high potassium in the hippocampal slice ⬇️

scientific article published on March 29, 1988

Gene expression changes after seizure preconditioning in the three major hippocampal cell layers

scientific article

Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism

scientific article

Glutamate receptor ion channels: structure, regulation, and function

scientific article

Glutamatergic Mechanisms Related to Epilepsy: Ionotropic Receptors ⬇️

scientific article published on July 13, 2012

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

scientific article

Identification of a site in glutamate receptor subunits that controls calcium permeability ⬇️

scientific article published on August 30, 1991

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application.

scientific article published on September 2015

Induction and expression rules of synaptic plasticity in hippocampal interneurons ⬇️

scientific article published on December 30, 2010

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

scientific article published on 06 September 2016

Inhibition by bradykinin of voltage-activated barium current in a rat dorsal root ganglion cell line: role of protein kinase C.

scientific article published on April 1991

Inhibition of glutamate receptor 2 translation by a polymorphic repeat sequence in the 5'-untranslated leaders.

scientific article published in April 2004

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

scientific article published on 28 July 2016

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

scientific article

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

scientific article published on 11 February 2013

Inhibitory effects of acetylcholine on neurones in the feline nucleus reticularis thalami ⬇️

scientific article published on October 1, 1976

Interneuron Diversity series: Interneuron research--challenges and strategies

scientific article

Ionotropic glutamate receptors: regulation by G-protein-coupled receptors.

scientific article published on 24 January 2013

Lead optimization studies of cinnamic amide EP2 antagonists

scientific article

Limiting stroke-induced damage by targeting an acid channel.

scientific article published in January 2005

Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus.

scientific article published on 28 October 2004

Midbrain reticular evoked inhibition of thalamic neurones [proceedings] ⬇️

scientific article published on February 1, 1977

Molecular biology of the glutamate receptors

scientific article published on January 1, 1992

Molecular cascades that mediate the influence of inflammation on epilepsy ⬇️

scientific article published on May 1, 2011

Mu opioid receptors participate in the excitatory effect of opiates in the hippocampal slice ⬇️

scientific article published on December 1, 1984

Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies

scientific article published on January 1, 1978

Neuroinflammatory targets and treatments for epilepsy validated in experimental models.

scientific article

Neuron-selective changes in RNA transcripts related to energy metabolism in toxic models of parkinsonism in rodents.

scientific article

Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.

scientific article

New wave of non-NMDA excitatory amino acid receptors ⬇️

scientific article published on October 1, 1991

Novel Microglia Cell Line Expressing the Human EP2 Receptor

scientific article published on 11 September 2019

Penicillin blocks hippocampal IPSPs, unmasking prolonged EPSPs ⬇️

scientific article published on May 18, 1979

Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus

scientific article published on 08 December 2020

Peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with anti-inflammatory properties

scientific article published on 15 November 2018

Possible mechanisms of enkephalin action on hippocampal CA1 pyramidal neurons

scientific article

Presynaptic inhibitory effect of acetylcholine in the hippocampus

scientific article published on 01 July 1981

Quantitative transcriptional neuroanatomy of the rat hippocampus: evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers

scientific article

Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice

scientific article

Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene

scientific article

Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.

scientific article published on 28 November 2012

Selectivity of amino acid transmitters acting at N-methyl-D-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors ⬇️

scientific article published on March 1, 1992

Single neuron studies of opiate action in the guinea pig myenteric plexus

scientific article published on 01 July 1975

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

scientific article

Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels

scientific article

Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines.

scientific article published on February 2003

Subunit-dependent modulation of kainate receptors by muscarinic acetylcholine receptors

scientific article

Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury

scientific article published on 11 February 2019

Text analysis of MEDLINE for discovering functional relationships among genes: evaluation of keyword extraction weighting schemes.

scientific article

The COX-2/prostanoid signaling cascades in seizure disorders

scientific article published on 02 December 2018

The First 50 Years of Molecular Pharmacology

scientific article

The excitatory action of acetylcholine on hippocampal neurones of the guinea pig and rat maintained in vitro ⬇️

scientific article published on February 23, 1981

The in vitro brain slice as a useful neurophysiological preparation for intracellular recording ⬇️

scientific article published on August 1, 1980

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

scientific article

The roles of metabotropic glutamate receptors in seizures and epilepsy

scientific article

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

scientific article published on 17 January 2015

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

scientific article

Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements.

scientific article published in September 1998

Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3' untranslated regions

scientific article published on 13 February 2009

Unraveling the role of zinc in memory

scientific article

Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro

scientific article published on 13 March 2015

Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats

scientific article published on 10 April 2020

Voltage-controlled plasticity at GluR2-deficient synapses onto hippocampal interneurons

scientific article

When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?

scientific article

Why Is It so Hard to Do Good Science?

scientific article published on 06 September 2018

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