List of works by Robert Lefkowitz

125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors

scientific article published on October 1982

3HWB4101—Caution about its role as an alpha-adrenergic subtype selective radioligand ⬇️

scientific article published on 01 June 1980

5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.

scientific article published on January 1991

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

scientific article

A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer

scientific article

A Serendipitous Scientist

scientific article

A beta-arrestin 2 signaling complex mediates lithium action on behavior

scientific article

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

scientific article

A brief history of G-protein coupled receptors (Nobel Lecture).

scientific article published on 6 May 2013

A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.

scientific article

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated

scientific article

A crystal clear view of the beta2-adrenergic receptor

scientific article published on 01 February 2008

A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy ⬇️

scientific article published on March 1, 1978

A family of receptors coupled to guanine nucleotide regulatory proteins

scientific article published on 01 May 1987

A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes ⬇️

scientific article published on February 25, 1980

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration

scientific article published on 01 January 1994

A magnificent time with the "magnificent seven" transmembrane spanning receptors

scientific article published on 01 March 2003

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activati

scientific article published on January 1990

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

scientific article

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

scientific article published on 01 March 1986

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data ⬇️

scientific article published on January 1, 1980

A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation

scientific article published on 01 August 1982

A role for Ni in the hormonal stimulation of adenylate cyclase

scientific article published in Nature

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation ⬇️

scientific article published on April 15, 1991

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

scientific article

A tale of two callings

scientific article published on 03 October 2011

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor ⬇️

scientific article published on August 10, 1980

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

scholarly article

Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes ⬇️

scientific article published on July 25, 1980

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

scientific article

Activation of adenylate cyclase by beta-adrenergic receptors: Investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release ⬇️

scientific article published on September 5, 1983

Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits

scientific article

Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization ⬇️

scientific article published on April 10, 1984

Activation-dependent conformational changes in {beta}-arrestin 2.

scientific article

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

scientific article

Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function

scientific article published in July 1999

Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts

scientific article published on 01 September 2000

Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines

scientific article published on 01 July 1976

Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization

scientific article published on January 1983

Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding

scientific article published in May 1976

Adrenergic Receptors in the Heart ⬇️

scientific article published on January 1, 1982

Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization

scientific article published in January 1989

Adrenergic receptors

scientific article published on 01 January 1990

Adrenergic receptors

scientific article published on 01 January 1988

Adrenergic receptors

scientific article published on 01 January 1980

Adrenergic receptors. Models for regulation of signal transduction processes

scientific article published on February 1990

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins

scientific article published on April 1988

Adrenergic receptors: molecular mechanisms of clinically relevant regulation

scientific article

Adrenergic receptors: recent insights into their mechanism of activation and desensitization.

scientific article published on January 1993

Affinity chromatography of human platelet alpha 2-adrenergic receptors

scientific article

Affinity chromatography of the beta-adrenergic receptor ⬇️

scientific article published on April 25, 1979

Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations

scientific article published on 01 January 1980

Agonist Interactions with α-Adrenergic Receptors ⬇️

scientific article published on 01 January 1982

Agonist versus antagonist binding to alpha-adrenergic receptors ⬇️

scientific article published on August 1, 1980

Agonist-Promoted High Affinity State of the β-Adrenergic Receptor in Human Neutrophils: Modulation by Corticosteroids* ⬇️

scientific article published on 01 October 1981

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase

scientific article published on 01 December 1987

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C ⬇️

scientific article published on August 1, 1995

Agonist-induced increase in apparent β-adrenergic receptor size ⬇️

scientific article published on January 1, 1978

Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system ⬇️

scientific article published on February 1, 1980

Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors ⬇️

scientific article published on March 1, 1978

Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets ⬇️

scientific article published on July 1, 1979

Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets ⬇️

scientific article published on July 1, 1978

Alfred Goodman Gilman (1941-2015).

scientific article

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library

scientific article

Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes

scientific article published on 25 September 2020

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch

scientific article

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene

scientific article published on May 1990

Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction and regulation by estrogens ⬇️

scientific article published on 01 November 1981

Alpha-Adrenergic Receptor Identification by [ 3 H]Dihydroergocryptine Binding ⬇️

scientific article published on May 21, 1976

Alpha-adrenergic receptor subtypes: Quantitative assessment by ligand binding ⬇️

scientific article published on May 7, 1979

Alpha-adrenergic receptors in liver membranes: Delineation with subtype selective radioligands ⬇️

scientific article published on January 19, 1981

Alpha2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: Direct demonstration by radioligand binding ⬇️

scientific article published on December 20, 1982

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

scientific article

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3

scientific article

Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites

Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands ⬇️

scientific article published on 01 May 1981

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

scientific article

An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits

scientific article

An assay for alpha-adrenergic receptor subtypes using [3H]dihydroergocryptine

scientific article published on 01 February 1980

An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser

scientific article

An interview with Robert J. Lefkowitz

scientific article published in February 2012

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

scientific article

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

scientific article published on 10 January 2019

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

scientific article published on 22 November 2005

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

scientific article published on 01 February 2020

Anomalous equilibrium binding properties of high-affinity racemic radioligands ⬇️

scientific article published on March 1, 1981

Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors

scientific article

Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation

scientific article published on May 2004

Antibodies raised against purified β-adrenergic receptors specifically bind β-adrenergic ligands ⬇️

scientific article published on May 1, 1979

Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain

scientific article published on April 1983

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways

scientific article published on October 2009

Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4

scientific journal article

Arresting developments in heptahelical receptor signaling and regulation

scientific article

Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener

scientific article

Arrestins come of age: a personal historical perspective

scientific article published on January 2013

Arylazide photoaffinity probe for alpha 2-adrenoceptors

scientific article published on October 1985

Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling

scientific article (publication date: 6 April 2000)

Association of sequestered beta-adrenergic receptors with the plasma membrane: A novel mechanism for receptor down regulation ⬇️

scientific article published on 01 October 1984

Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice

scientific article published in November 2001

Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation

scientific article published on 01 January 1999

Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2

scientific article (publication date: 22 October 2002)

Beta-Arrestins: new roles in regulating heptahelical receptors' functions

scientific article

Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.

scientific article published in February 1993

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor

scientific journal article

Beta-adrenergic receptor kinase: primary structure delineates a multigene family

scientific article

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization

scientific article published on 01 January 1993

Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids

scientific article published on 01 July 1988

Beta-adrenergic receptors: Regulatory role of agonists ⬇️

scientific article published on January 1, 1978

Beta-adrenergic receptors: biochemical mechanisms of physiological regulation

scientific article published on April 1984

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors

scientific article published on September 1986

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

scientific article

Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis

scientific article

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

scientific article (publication date: 24 November 2000)

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression

scientific article published on 15 February 2007

Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor

scientific article

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

scientific article

Beta-arrestin-2 regulates the development of allergic asthma

scientific article

Beta-arrestin-biased ligands at seven-transmembrane receptors

scientific article

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

scientific article

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

scientific article

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

scientific article

Beta-arrestin-mediated localization of smoothened to the primary cilium

scientific article published on 22 May 2008

Beta-arrestin-mediated signaling regulates protein synthesis.

scientific article published on 14 February 2008

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family ⬇️

scientific article published on September 5, 1992

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes

scholarly article

Beta-arrestins and cell signaling

scientific article (publication date: 2007)

Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration

scientific article published on 02 June 2008

Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.

scientific article published in April 1999

Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery

scientific article published on 01 May 2018

Biased signalling: from simple switches to allosteric microprocessors

scientific article published on 5 January 2018

Binding of G protein beta gamma-subunits to pleckstrin homology domains

scientific article published on 01 April 1994

Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling

scientific article

Biochemical characterization of the BETA-adrenergic receptor of the frog erythrocyte ⬇️

scientific article published on December 14, 1979

Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies.

scientific article

Biological activity of agarose-immobilized catecholamines ⬇️

scientific article (publication date: 24 September 1976)

Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.

scientific article published in July 1995

Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

scientific article published in May 2001

Cardiac function in genetically engineered mice with altered adrenergic receptor signaling

scientific article published on April 1997

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

scientific journal article

Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma

scientific article published on 01 May 1995

Catecholamine binding to the beta-adrenergic receptor ⬇️

scientific article published on February 1, 1977

Catecholamine receptors: structure, function, and regulation.

scientific article

Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number

scientific article published on 01 January 1981

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor ⬇️

scientific article published on June 1, 1983

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling ⬇️

scientific article published on August 25, 1982

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites ⬇️

scientific article published on May 1, 1975

Catecholamines, cardiac beta-adrenergic receptors, and heart failure

scientific article published on 01 April 2000

Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors ⬇️

scientific article published on April 10, 1984

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

scientific article

Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase ⬇️

scientific article published on June 25, 1975

Characterization of alpha 2-adrenergic receptor subtype-specific antibodies

scientific article published on 01 March 1993

Characterization of the G Protein-coupled Receptor Kinase GRK4

scientific article published in Journal of Biological Chemistry

Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants

scientific article

Chemical modification of alpha 2-adrenoceptors. Possible role for tyrosine in the ligand binding site

scientific article published on 01 November 1986

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

scientific article

Chromosomal organization of adrenergic receptor genes

scientific article

Chronic guanethidine treatment increases cardiac β-adrenergic receptors ⬇️

scientific article published on May 18, 1978

Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation

scientific article published in September 1986

Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors

scientific article

Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1

scientific article

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype

scientific article

Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region

scientific article published in February 1993

Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors

scientific article published on 01 January 1988

Cloning of the cDNA for the human beta 1-adrenergic receptor

scientific article

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

scientific article

Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain.

scientific article published in December 1996

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

scientific journal article

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

scientific article

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase ⬇️

scientific article published on July 15, 1991

Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

scientific article

Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor

scientific article

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

scientific article published on 02 July 2020

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

scientific article

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation ⬇️

scientific article published on January 25, 1992

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

scientific article

Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.

scientific article

Constitutively active mutants of the alpha 2-adrenergic receptor

scientific article published on August 1993

Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice

scientific article published in July 1998

Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit

scientific article published on 01 October 1990

Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes

scientific article published on 01 March 1981

Corticosteroid-induced differential regulation of beta-adrenergic receptors in circulating human polymorphonuclear leukocytes and mononuclear leukocytes

scientific article published on 01 September 1980

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process

scientific article published on 01 March 1991

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

scientific article published on 01 January 1999

Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.

scientific article

Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label

scientific article published on May 1985

Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe

scientific article published on September 1983

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

scientific article

Crystallizing thinking about the beta2-adrenergic receptor.

scientific article published on 31 January 2008

Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase)

scientific article published on 01 August 1991

Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

scientific article published on November 2002

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

scientific article

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions

scientific article published in May 1987

Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2

scientific article

Desensitization of G protein-coupled receptors

scientific article published on January 1996

Desensitization of G protein-coupled receptors and neuronal functions

scientific article published in January 2004

Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes

scientific article published on October 1, 1979

Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles ⬇️

scientific article published on March 10, 1983

Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

scientific article (publication date: 31 March 1992)

Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor

scientific article published on 01 February 1985

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity ⬇️

scientific article published on August 10, 1984

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

scientific article

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors

scientific article published on 30 July 2019

Determination of subtype selectivity of alpha-adrenergic antagonists: comparison of selective and nonselective radioligands ⬇️

scientific article published on 01 July 1981

Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling

scientific article

Development of an affinity ligand for purification of .alpha.2-adrenoceptors from human platelet membranes ⬇️

scientific article published on July 1, 1984

Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization ⬇️

scientific article published on May 25, 1978

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor

scientific article

Different sedimentation properties of agonist- and antagonist-labelled platelet alpha2 adrenergic receptors ⬇️

scientific article published on June 16, 1981

Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes

scientific article published on April 1994

Differential effects of GTP on the coupling of β-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes application of new methods for the analysis of receptor-effector coupling ⬇️

scientific article published on August 22, 1979

Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes

scientific article published on January 1, 1981

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

scientific article

Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.

scientific article published on December 2002

Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases

scientific article published on February 1996

Differential regulation of the α2-adrenergic receptor by Na+ and guanine nucleotides ⬇️

scientific article published on December 25, 1980

Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle

Direct Demonstration of Impaired Functionality of a Purified Desensitized β-Adrenergic Receptor in a Reconstituted System ⬇️

scientific article published on August 24, 1984

Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation

scientific article

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

scientific article

Direct studies of β-adrenergic receptors in intact frog erythrocytes ⬇️

scientific article published on December 15, 1976

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.

scientific article

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis ⬇️

scientific article published on January 25, 1992

Diseased G protein-coupled receptors

scientific article published on November 1993

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

scientific article (publication date: 5 September 2003)

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

scientific article published on 21 February 2006

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

scholarly article

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

scientific article

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

scientific article published on 01 July 1995

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

scientific article published on August 2011

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

scientific article published on 10 January 2019

Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain

scientific article published on January 1994

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)

scientific article

Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release ⬇️

scientific article published on April 10, 1978

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice

scientific article (publication date: 24 April 2003)

Dual couplings of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein ⬇️

scientific article published on 01 January 1991

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

scientific article published in February 2001

Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase ⬇️

scientific article published on February 1, 1977

Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.

scientific article

Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists

scientific article published on 01 June 1984

Effect of thyroid status on α- and β-catecholamine responsiveness of hamster adipocytes ⬇️

scientific article published on December 18, 1981

Effector coupling mechanisms of the cloned 5-HT1A receptor

scientific article

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

scientific article

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins

scientific article

Endogenous proteinases modulate the function of the β-adrenergic receptor-adenylate cyclase system ⬇️

scientific article published on December 20, 1984

Enhanced adenylate cyclase activity of turkey erythrocytes following treatment with β-adrenergic receptor antagonists ⬇️

scientific article published on December 15, 1984

Enhanced morphine analgesia in mice lacking beta-arrestin 2

scientific journal article

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

scientific article published in April 1994

Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein

scientific article

Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.

scientific article published in November 2003

Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries

scientific article published in May 1998

Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery

scientific article

Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

scientific article published on 04 April 2001

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

scientific article published in January 1998

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

scientific journal article

Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity ⬇️

scientific article published on August 25, 1981

Ex vivo adenovirus-mediated gene transfer to the adult rat heart

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Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.

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Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

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Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

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Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification

scientific article published on November 1990

Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

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Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

scientific article (publication date: 4 June 1999)

Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave

scientific article published on February 2009

From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors ⬇️

scientific article published on January 1, 1992

Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes.

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Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor

scientific article published on 01 March 1997

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

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Functional consequences of altering myocardial adrenergic receptor signaling

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Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

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Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein

scientific article published on 01 March 1987

Functional integrity of desensitized beta-adrenergic receptors ⬇️

scientific article published on May 25, 1983

Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles

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Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines ⬇️

scientific article published on 01 July 1983

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

scientific article published in March 1986

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

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Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase

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G Protein-coupled Receptor Kinase 5 in Cultured Vascular Smooth Muscle Cells and Rat Aorta

scientific article published on 01 December 1997

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

scientific article published on 02 October 2009

G beta gamma interactions with PH domains and Ras-MAPK signaling pathways

scientific article published on April 1995

G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor

scientific article published on 01 July 1995

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein

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G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development

scientific article published on 01 August 1998

G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.

scientific article published in October 1997

G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.

scientific article published on 17 October 2003

G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95

scientific article (publication date: 11 January 2002)

G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction

scientific article (publication date: 20 August 1999)

G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.

scientific article published on 28 September 2006

G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.

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G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition

scientific article published on 01 March 1996

G protein-coupled receptor kinases

scientific article published on 01 January 1998

G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases

scientific article published on 01 December 1997

G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor

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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

scientific article published on January 1996

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal

scientific article

G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.

scientific article published on 31 March 2003

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity ⬇️

scientific article published on December 15, 1991

G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer

scientific article published on 10 May 2006

G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.

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G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins

scientific article published on January 1, 1992

GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation

scientific article (publication date: 11 July 2003)

GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6

scientific article (publication date: 5 May 2000)

GPCR signaling: conformational activation of arrestins

scientific article published on 01 August 2018

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

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GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

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GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain

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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

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Gene transfer strategies for augmenting cardiac function

scientific article published on July 1997

Genetic mapping of the ?-arrestin 1 and 2 genes on mouse Chromosomes 7 and 11 respectively

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Genetic regulation of beta-adrenergic receptors

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Genomic organization of adrenergic and serotonin receptors in the mouse: Linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution ⬇️

scientific article published on June 1, 1991

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

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Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).

scientific article published on 26 July 2008

Guanine nucleotides and alpha1 adrenergic receptors in the heart ⬇️

scientific article published on 01 January 1983

Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes ⬇️

scientific article published on September 1, 1983

Hepatic alpha-adrenergic receptors. Identification and subcellular localization using [3H]dihydroergocryptine ⬇️

scientific article published on September 10, 1978

Heptahelical receptor signaling: beyond the G protein paradigm.

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Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes ⬇️

scientific article published on May 25, 1980

Historical review: a brief history and personal retrospective of seven-transmembrane receptors

scientific article published in August 2004

Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2

scientific article (publication date: 27 December 2002)

Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor

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Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment

scientific article published on 01 April 1985

Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung

scientific article published on 01 September 1985

Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes

scientific article published on November 1982

Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition

scientific article published on 01 June 1982

Hormones, Receptors, and Cyclic AMP: Their Role in Target Cell Refractoriness ⬇️

scientific article published on January 1, 1980

Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes

scientific article (publication date: July 1988)

Human cardiac beta-adrenergic receptors: Subtype heterogeneity delineated by direct radioligand binding ⬇️

scientific article published on 01 August 1983

Human platelet adenylate cyclase: delineation of distinct stimulatory and inhibitory guanine nucleotide regulatory pathways

scientific article published on 01 January 1982

Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes

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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart

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Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes ⬇️

scientific article published on December 1, 1981

Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor

scientific article published on March 1988

Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

scientific article (publication date: 16 April 1999)

Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3

scientific article (publication date: 27 July 2001)

Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol ⬇️

scientific article published on July 10, 1975

Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding ⬇️

scientific article published on February 1, 1978

Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding

scientific article

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding ⬇️

scientific article published on January 1, 1976

Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding

scientific article

Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor

scientific article

Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor

scientific article

Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe

scientific article

Identification of the subunit structure of rat pineal adrenergic receptors by photoaffinity labeling

scientific article published on April 1986

Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine ⬇️

scientific article published on June 25, 1984

Identification, Quantification, and Localization of mRNA for Three Distinct Alpha1Adrenergic Receptor Subtypes in Human Prostate ⬇️

scientific article published on 01 August 1993

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

scientific article published on March 1994

Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity

scientific article published on December 1995

Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.

scientific article

In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids

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In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function

scientific article published on 01 August 1999

In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction

scientific article

Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.

scientific article published in December 2003

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

scientific article

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

scientific journal article

Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.

scientific article published on June 1994

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors

scientific article

Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy

scientific article

Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor

scientific article published on July 2000

Inhibition of the beta-adrenergic receptor kinase by polyanions.

scientific article published in April 1989

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

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Inspiring the next generation of physician-scientists

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Interactions of agonists with platelet alpha 2-adrenergic receptors

scientific article published on 01 March 1982

International Union of Pharmacology nomenclature of adrenoceptors

scientific article published on June 1994

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.

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International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?

scientific article published in October 2010

Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance

scientific article published on 01 February 2000

Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling

scientific article published in July 2011

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor

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Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands

scientific article published on 01 January 1981

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

scientific article published on September 10, 1992

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase

scientific article published on January 1992

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

scientific article (publication date: 23 May 2003)

Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure

scientific article published on 24 January 2005

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice

scientific article published in January 1997

Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase

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Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology

scientific article published in February 1994

Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor

scientific article published on 01 May 1989

Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes ⬇️

scientific article published on March 10, 1980

Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody ⬇️

scientific article published on April 1, 1980

Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors ⬇️

scientific article published on May 10, 1978

Mammalian .beta.2-adrenergic receptor: purification and characterization ⬇️

scientific article published on September 25, 1984

Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit

scientific article

Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains ⬇️

scientific article published on July 10, 1984

Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps

scientific article published on September 1983

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

scientific article published on 25 September 2018

Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene

scientific article published on 01 February 1995

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.

scientific article published in July 1986

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.

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Mechanism of β2AR regulation by an intracellular positive allosteric modulator

scientific article published on 27 June 2019

Mechanisms involved in adrenergic receptor desensitization.

scientific article published on August 1990

Mechanisms of beta-adrenergic receptor desensitization and resensitization

scientific article published in January 1998

Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase

scientific article published on 01 August 1982

Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors

scientific article published on June 1984

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration

scientific article published on April 1996

Mitogenic signaling via G protein-coupled receptors

scientific article published on December 1996

Model systems for the study of seven-transmembrane-segment receptors ⬇️

scientific article published on January 1, 1991

Molecular Biology of Adrenergic Receptors

scientific article published on 01 January 1988

Molecular Mechanisms of Coupling in Hormone Receptor‐Adenylate Cyclase Systems ⬇️

scientific article published on January 1, 1982

Molecular and regulatory properties of adrenergic receptors

scientific article published on January 1987

Molecular basis for interactions of G protein betagamma subunits with effectors

scientific article published on May 1998

Molecular biology of adrenergic receptors in the rat and frog central nervous system ⬇️

scientific article published on September 1, 1984

Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships

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Molecular characterization of the β-adrenergic receptor of frog erythrocytes ⬇️

scientific article published on July 1, 1982

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype

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Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5 ⬇️

scientific article published on April 5, 1991

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor

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Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor

scientific article published on 01 February 2020

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors

scientific article published on 19 September 2011

Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization

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Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors

scientific article published on January 1, 1978

Molecular mechanisms of beta-adrenergic receptor desensitization

scientific article published in January 1987

Molecular mechanisms of beta-adrenergic receptor desensitization

scientific article published on 01 January 1980

Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model

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Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors

scientific article published on 01 January 1981

Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations ⬇️

scientific article published on March 1, 1977

Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases

scientific article published on July 1996

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

scientific journal article

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

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Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes

scientific article (publication date: February 1978)

Multiple effects of guanine nucleotides on human platelet adenylate cyclase ⬇️

scientific article published on September 20, 1979

Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity

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Multiple ligand-specific conformations of the β2-adrenergic receptor

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Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors

scientific article published on February 1990

Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors ⬇️

scientific article published on November 1, 1979

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells

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Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

scientific article published on 01 December 1999

Mutagenesis of the beta2-Adrenergic Receptor: How Structure Elucidates Function ⬇️

scientific article published on January 1, 1992

Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding

scientific article published on 01 July 1995

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration ⬇️

scientific article published on February 1, 1991

Myocardial G protein-coupled receptor kinases: implications for heart failure therapy

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Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice

scientific article published on September 1996

Myocardial beta-adrenergic receptors from adrenalectomized rats: impaired formation of high-affinity agonist-receptor complexes ⬇️

scientific article published on 01 February 1981

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

scientific article published in October 1994

Myocardial guanylate cyclase: Properties of the enzyme and effects of cholinergic agonists in vitro ⬇️

scientific article published on January 23, 1975

Myocardial overexpression of adrenergic receptors and receptor kinases

scientific article published on 01 January 1998

N-formyl peptide receptors internalize but do not recycle in the absence of arrestins

scientific article published on 28 August 2003

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor

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Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes

scientific article published in August 1976

Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

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New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors

scientific article published on December 2006

Odorant receptors and desensitization proteins colocalize in mammalian sperm

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Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins

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Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors

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Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase

scientific article published on September 1992

Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury

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Overview of the Alliance for Cellular Signaling

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Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

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PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching

scientific article published in December 2004

Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6

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Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family

scientific article (publication date: 11 November 1994)

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor

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Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid

scientific article published on 01 September 1980

Pharmacological Characterizations of Adrenergic Receptors in Human Adipocytes ⬇️

scientific article published on February 1, 1981

Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model

scientific article published on 15 January 2012

Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning ⬇️

scientific article published on July 1, 1992

Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor

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Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes

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Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes ⬇️

scientific article published on June 29, 1984

Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells

scientific article published on 01 December 1985

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism

scientific article published on September 1985

Phosducin, potential role in modulation of olfactory signaling

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Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway

scientific article published on May 1996

Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies

scientific article published on October 1996

Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity

scientific article (publication date: 11 July 1997)

Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase

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Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors

scientific article published on August 2002

Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways

scientific article published on February 1988

Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase

scientific article published on 01 May 1989

Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase

scientific article published on January 1983

Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization

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Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulator

scientific article published on 01 June 1985

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C

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Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

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Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution

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Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors ⬇️

scientific article published on September 1, 1984

Photoaffinity labeling of human platelet and rabbit kidney alpha 2-adrenoceptors with [3H]SKF 102229.

scientific article published on June 1986

Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe ⬇️

scientific article published on February 25, 1984

Photoaffinity labeling of the beta-adrenergic receptor ⬇️

scientific article published on November 25, 1981

Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: Degradation of the Mr = 49,000 protein explains apparent heterogeneity ⬇️

scientific article published on March 15, 1984

Photoaffinity labeling of β-adrenergic receptors in mammalian tissues ⬇️

scientific article published on December 1, 1984

Photoaffinity labelling of mammalian beta-adrenergic receptors: Metal-dependent proteolysis explains apparent heterogeneity ⬇️

scientific article published on January 27, 1983

Plasma membrane receptors

scientific article published on October 1983

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

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Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

scientific article published on 01 May 1995

Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

scientific article published on 01 May 1999

Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients

scientific article published on 01 September 1983

Potent beta-adrenergic antagonist possessing chemically reactive group

scientific article published on November 1980

Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes

scientific article published on January 1997

Potentiation of beta-adrenergic signaling by gene transfer

scientific article published on May 1997

Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets ⬇️

scientific article published on May 29, 1981

Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction

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Production of adrenergic receptors in yeast

scientific article published on 01 January 1996

Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance

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Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning

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Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.

scientific article

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

scientific article (publication date: 23 August 2002)

Protein kinases that phosphorylate activated G protein-coupled receptors.

scientific article published on February 1995

Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase ⬇️

scientific article published on December 8, 1983

Purification and characterization of the beta-adrenergic receptor kinase

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Purification and characterization of the human platelet alpha 2-adrenergic receptor.

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Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit ⬇️

scientific article published on June 10, 1981

Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.

scientific article published on 25 April 2003

Quantifying ligand bias at seven-transmembrane receptors.

scientific article

Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique ⬇️

scientific article published on July 1, 1979

Radioligand Binding Studies of Adrenergic Receptors: New Insights into Molecular and Physiological Regulation ⬇️

scientific article published on January 1, 1980

Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.

scientific article published on October 1996

Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase

scientific article published on 01 August 1997

Recent developments in biased agonism

scientific article

Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases

scientific article

Receptor regulation: beta-arrestin moves up a notch

scientific article published on 01 December 2005

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems ⬇️

scientific article published on April 25, 1992

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice

scientific article published on September 1996

Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.

scientific article published on 7 February 2005

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway ⬇️

scientific article published on August 31, 1995

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

scientific article published on October 1998

Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide

scientific article

Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

scientific article published on 7 January 2004

Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit ⬇️

scientific article published on August 25, 1984

Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system ⬇️

scientific article published on August 1, 1983

Reconstitution of the beta-adrenergic receptor

scientific article published on January 1985

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function

scientific article

Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin

scientific article

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization

scientific article

Regulation of G protein-coupled receptor signaling by scaffold proteins

scientific article

Regulation of G protein-coupled receptors by agonist-dependent phosphorylation

scientific article published on January 1990

Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination

scientific article published on 5 September 2003

Regulation of adenylate cyclase coupled beta-adrenergic receptors

scientific article published on January 1976

Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines

scientific article published on August 1, 1976

Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro ⬇️

scientific article published on 01 May 1976

Regulation of adenylyl cyclase-coupled beta-adrenergic receptors

scientific article published on January 1988

Regulation of adrenergic receptor function by phosphorylation

scientific article published on January 1986

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells

scientific article

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase

scientific article published in Journal of Biological Chemistry

Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression

scientific article published on January 1991

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2

scientific article

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides ⬇️

scientific article published on August 10, 1976

Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins

scientific article

Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A. Evidence for discrete classes of insulin binding sites.

scientific article published on November 1982

Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.

scientific article published on 22 January 2001

Regulation of mitogen-activated protein kinase pathways by catecholamine receptors

scientific article published on 01 January 1998

Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors

scientific article

Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes ⬇️

scientific article published on August 10, 1977

Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone ⬇️

scientific article published on October 1, 1977

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

scientific article (publication date: 9 November 2001)

Regulation of the beta 2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone

scientific article published on 01 June 1988

Regulation of transmembrane signaling by receptor phosphorylation

scientific article published on March 1987

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

scientific article

Regulation of β-Adrenergic Receptors by Steroid Hormones ⬇️

scientific article published on January 1, 1984

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

scientific article published on 06 December 2013

Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery

scientific article

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

scientific article published in Nature

Reply: receptor specificity of G-protein-coupled receptor kinases

scientific article published on 01 October 2000

Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.

scientific article

Resonating to the music of ubiquitination

scientific article published on 01 December 2004

Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer

scientific article published on October 1997

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase ⬇️

scientific article published on May 28, 1991

Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes

scientific article published on 01 September 1980

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

scientific article published on August 28, 1992

Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

scientific article published on August 1996

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

scientific article published on February 2000

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor

scientific article published on March 1990

Role of phosphorylation in desensitization of the beta-adrenoceptor

scientific article published on May 1990

Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor

scientific article published on January 1, 1991

S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking

scientific article published on August 2008

Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization ⬇️

scientific article published on July 1, 1979

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

scientific article published on 02 June 2009

Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters

scientific article

Separation of solubilized alpha and beta adrenergic receptors by affinity chromatography ⬇️

scientific article published on May 14, 1979

Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis

scientific article published on February 1999

Seven transmembrane receptors: a brief personal retrospective.

scientific article published on 10 November 2006

Seven-transmembrane receptor signaling through beta-arrestin

scientific article

Seven-transmembrane receptors

scientific article (publication date: September 2002)

Seven-transmembrane-spanning receptors and heart function

scientific article

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling

scientific article

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism ⬇️

scientific article published on March 5, 1992

Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor ⬇️

scientific article published on October 25, 1977

Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries

scientific article published on 16 May 2018

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

scientific article

SnapShot: β-Arrestin Functions

scientific article published on 01 September 2020

Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes ⬇️

scientific article published on April 25, 1976

Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity

scientific article published on 01 November 1983

Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells

scientific article published on 01 May 1987

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

scientific article published on 26 March 2018

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes ⬇️

scientific article published on March 1, 1977

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles

scientific article published on 01 February 1985

Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors

scientific article

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

scientific journal article

Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling

scientific article published on January 1999

Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.

scientific article published on 7 September 2004

Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase

scientific article published in September 1974

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

scientific article

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors

scientific article

Structure and Function of the Adrenergic Receptor Family ⬇️

scientific article published on January 1, 1991

Structure and Regulation of G Protein-Coupled Receptors: The β2-Adrenergic Receptor as a Model

scientific article published on January 1, 1991

Structure and function of beta-adrenergic receptors: regulation at the molecular level

scientific article published on January 1, 1984

Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin

scientific article published on December 1987

Structure and mechanism of the G protein-coupled receptor kinases.

scientific article

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

scientific article

Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex

scientific article published on 18 November 2019

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

scientific article published on 16 January 2020

Structure of the adrenergic and related receptors

scientific article

Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies ⬇️

scientific article published on January 1, 1976

Subclassification of alpha-adrenergic receptors by direct binding studies ⬇️

scientific article published on April 15, 1979

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro ⬇️

scientific article published on July 25, 1975

Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization

scientific article

Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function.

scientific article published in January 2005

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

scientific article published on November 1997

Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization

scientific article published on May 1997

Synthesis of iodine-125 labeled (.+-.)-15-[4-azidobenzyl]carazolol: a potent .beta.-adrenergic photoaffinity probe ⬇️

scientific article published on June 1, 1983

Synthetic nanobodies as angiotensin receptor blockers

scientific article published on 04 August 2020

Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase

scientific article published on January 1990

Targeting G protein-coupled receptor kinases to their receptor substrates

scientific article published on May 1997

Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis

scientific article

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

scientific article

Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins

scientific article

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

scientific article

Teaching old receptors new tricks: biasing seven-transmembrane receptors

scientific article

Techniques for the study of the biochemical basis of drug action ⬇️

scientific article published on January 1, 1976

Temperature immutability of adenyl cyclase-coupled β adrenergic recptors

scientific article published in Nature

The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin

scientific article published on May 1998

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain ⬇️

scientific article published on October 1, 1992

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity

scientific article

The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing

scientific article published in July 2000

The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation

scientific article (publication date: 8 October 1999)

The Human Placenta—A Rich Source of β-Adrenergic Receptors: Characterization of the Receptors in Particulate and Solubilized Preparations* ⬇️

scientific article published on 01 June 1980

The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2

scientific journal article

The adrenergic receptors

scientific article published on January 1990

The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family.

scientific article published on January 1990

The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity ⬇️

scientific article published on November 1, 1991

The annual ASCI meeting: does nostalgia have a future?

scientific article

The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling ⬇️

scientific article published on October 25, 1982

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

scientific article

The beta-adrenergic receptor and adenylate cyclase

scientific article published on April 13, 1976

The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.

scientific article published in January 1988

The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking ⬇️

scientific article published on May 1, 1982

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

scientific article

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase

scientific article published on April 1993

The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling ⬇️

scientific article published on July 10, 1983

The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor

scientific journal article

The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C

scientific article published on 01 December 1989

The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels

scholarly article

The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

scientific article published in September 1984

The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety

scientific article published on 01 January 1987

The mammalian beta-adrenergic receptors.

scientific article published on January 1989

The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors

scientific article published on January 1, 1979

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis

scientific article published in Journal of Biological Chemistry

The new biology of drug receptors

scientific article

The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states

scientific article published on 01 May 1982

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase ⬇️

scientific article published on October 1, 1991

The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals

scientific article

The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification

scientific article

The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome

scientific article

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation

scientific article published on 6 December 2002

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2 ⬇️

scientific article published on May 5, 1993

The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.

scientific article published on May 2005

The third beta is not the charm

scientific article published on July 1996

The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility

scientific article published on 15 May 2020

Therapeutic potential of β-arrestin- and G protein-biased agonists.

scientific article published on 21 December 2010

Thyroid hormone modulation of agonist - beta-adrenergic receptor interactions in the rat heart ⬇️

scientific article published on 01 June 1981

Thyroid hormone regulation of beta-adrenergic receptor number ⬇️

scientific article published on April 25, 1977

Thyroxine and Propylthiouracil Effects on Alpha- and Beta-Adrenergic Receptor Number, ATPase Activities, and Sialic Acid Content of Rat Cardiac Membrane Vesicles ⬇️

scientific article published on November 1, 1979

Trafficking of G protein-coupled receptors

scientific article published on September 2006

Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination

scientific article published on 6 February 2003

Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems

scientific article published in August 1985

Transduction of receptor signals by beta-arrestins

scientific article

Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine

scientific article published on January 1997

Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases

scientific article published on April 1996

Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling

scientific article published on August 1997

Translocation and Uncoupling of theβ-Adrenergic Receptor in Rat Lung after Catecholamine Promoted Desensitizationin Vivo ⬇️

scientific article published on 01 October 1984

Turning off the signal: desensitization of beta-adrenergic receptor function

scientific article published on August 1990

Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level

scientific article published in October 1989

Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor

Tyrosine phosphorylation of G protein alpha subunits by pp60c-src ⬇️

scientific article published on July 1, 1992

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation

scientific article

Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding ⬇️

scientific article published on April 25, 1979

Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes

scientific article published on 01 October 1980

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes

scientific article

Visualization of arrestin recruitment by a G-protein-coupled receptor

scientific article (publication date: 14 August 2014)

When 7 transmembrane receptors are not G protein-coupled receptors

scientific article

alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro

scientific article published on 01 May 2000

beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport

scientific journal article

beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation

scientific article published on 02 November 2001

beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors

scientific article (publication date: 8 December 2000)

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation

scientific article published on 01 March 1988

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

scientific article

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

scholarly article

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

scientific article published on 02 January 2002

beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.

scientific article

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

scientific article (publication date: 9 November 2001)

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

scientific journal article

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice

scientific article

beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

scientific article

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

scientific article

beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.

scientific article published on October 2004

beta-arrestin-biased agonism at the beta2-adrenergic receptor

scientific article published on 17 December 2007

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

scientific article

beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis

scientific article (publication date: 14 April 2000)

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor

scientific article

beta-arrestins: traffic cops of cell signaling

scientific article published on April 2004

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

scientific article

beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics

scientific article published on 28 November 2007

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure

scientific article

cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.

scientific article

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor

scientific article

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

scientific article

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

scientific journal article

α-Adrenergic Receptors in Human Adipocyte Membranes: Direct Determination by [3H]Yohimbine Binding ⬇️

scientific article published on 01 April 1981

β-Adrenergic receptors: Evidence for negative cooperativity ⬇️

scientific article published on June 16, 1975

β-Adrenergic receptors: Solubilization of (−)[3H]alprenolol binding sites from frog erythrocyte membranes ⬇️

scientific article published on January 26, 1976

β-Adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants ⬇️

scientific article published on August 9, 1979

β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration

scientific article

β-Arrestin-mediated receptor trafficking and signal transduction

scientific article

β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis ⬇️

scientific article published on October 8, 2003

β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.

scientific article

β-Arrestin2 mediates progression of murine primary myelofibrosis

scientific article published on 21 December 2017

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

scientific article

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility

scientific article published on 27 December 2018

β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix

scientific article published on March 2011

⁸⁹Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer

scientific article

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