List of works by Brian Kobilka

1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization

scientific article published on 06 December 2019

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability

scientific article published on 01 November 2018

A device for separated and reversible co-culture of cardiomyocytes

scientific article

A fluorescent probe designed for studying protein conformational change

scientific article

A general protocol for the generation of Nanobodies for structural biology

scientific article

A genetically engineered cell-based biosensor for functional classification of agents

scientific article

A monoclonal antibody for G protein-coupled receptor crystallography

scientific article

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

scholarly article

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins

scientific article

A new era of GPCR structural and chemical biology

scientific article

A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B

scientific article

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists

scientific article

A single point mutation in the seventh hydrophobic domain of the alpha 2-adrenergic receptor changes antagonist binding specificity to that of a beta receptor

scientific article published on January 1991

Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice

scientific article published in November 2002

Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation

scientific article

Activation and allosteric modulation of a muscarinic acetylcholine receptor

scientific article

Activation of G protein-coupled receptors

scientific article published on January 2007

Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine

scientific article published on 09 March 2020

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

scientific article

Adrenergic Receptors From Molecular Structure to in vivo function

scientific article published on July 1997

Adrenergic receptor signal transduction and regulation

scientific article

Adrenergic receptors as models for G protein-coupled receptors

scientific article published on January 1, 1992

Agonist binding: a multistep process

scientific article

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

scientific article published on 15 May 2001

Agonist-induced conformational changes in the beta2 adrenergic receptor

scientific article

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

scientific article

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

scientific article published on 29 June 2016

Allosteric modulation of beta2-adrenergic receptor by Zn(2+).

scientific article published in January 2002

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

Allosteric regulation of G protein-coupled receptor activity by phospholipids.

scientific article

Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene

scientific article published on May 1990

Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns

scientific article published in January 1999

Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies.

scientific article published in September 1998

Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand-binding specificity

scientific article published in July 1993

Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor

scientific article

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability

scientific article published on 13 June 2018

An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor

scientific article published on 01 June 2020

An improved yeast surface display platform for the screening of nanobody immune libraries

scientific article published in Scientific Reports

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

scientific article

Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensor

scientific article published on 01 September 2002

Analysis of β2AR-Gs and β2AR-Gi complex formation by NMR spectroscopy

scientific article published on 31 August 2020

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

scientific article published on 10 January 2019

Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization

scientific article published on July 1994

Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors

scientific article

Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox

scientific journal article

Applications of molecular replacement to G protein-coupled receptors

scientific article published on 18 October 2013

Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin

scientific article published on February 1996

Assembly of a GPCR-G Protein Complex

scientific article published on 09 May 2019

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability

scientific article published on 05 November 2018

Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins

scientific article published on 21 January 2022

Author Correction: Structural insights into the activation of metabotropic glutamate receptors

scientific article published on 01 March 2019

Author Correction: Structural insights into μ-opioid receptor activation

scientific article published on 29 July 2020

Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice

scientific article

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice

scientific article

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

scientific article published on 22 October 2020

Brian Kobilka: chipping away at the β2-adrenergic receptor. Interview by Ruth Williams

scientific article published in June 2013

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.

scientific article published on 05 October 2016

Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors

scientific journal article

Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease

scientific article

Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

scientific article published in August 1996

Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes

scientific article published on 3 July 2002

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

scientific article

Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor.

scientific article

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype

scientific article

Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor

scientific article published on August 1992

Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors

scientific article published on 01 January 1988

Cloning of the cDNA for the human beta 1-adrenergic receptor

scientific article

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

scientific article

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding ⬇️

scientific article published on July 1, 1992

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

scientific article

Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy

scientific article published on 15 May 2019

Conformational Plasticity of Human Protease-Activated Receptor 1 upon Antagonist- and Agonist-Binding

scientific article published on 15 August 2019

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

scientific article

Conformational complexity of G-protein-coupled receptors

scientific article published on 13 July 2007

Conformational dynamics of single G protein-coupled receptors in solution

scientific article published on 21 October 2011

Conformational transitions of a neurotensin receptor 1-Gi1 complex

scientific article published on 26 June 2019

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties

scientific article published on 20 February 2017

Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability

scientific article published on 29 July 2019

Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

scientific article published on 01 May 2019

Counting low-copy number proteins in a single cell

scientific article

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

scientific article published on 25 June 2006

Covalent agonists for studying G protein-coupled receptor activation

scientific article

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

scientific article published on 24 May 2017

Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket

scientific article published on 06 February 2017

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

scientific article

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1

scientific article published in Nature

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

scientific article

Crystal structure of the β2 adrenergic receptor-Gs protein complex

scientific article

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

scientific article

Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology

article

D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype

scientific article published in October 1998

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions

scientific article published in May 1987

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.

scientific article published on 25 October 2017

Development and characterization of pepducins as Gs-biased allosteric agonists

scientific article

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

scientific article published in Nature Communications

Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study

scientific article published on 14 December 2020

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor

scientific article published on May 1998

Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes

scientific article published on 22 July 2005

Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors

scientific journal article

Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons

scientific article

Diverse GPCRs exhibit conserved water networks for stabilization and activation

scientific article published on 06 February 2019

Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR

scientific article

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

scientific article published in February 2001

Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability

scientific article

Effective application of bicelles for conformational analysis of G protein-coupled receptors by hydrogen/deuterium exchange mass spectrometry

scientific article published on 5 March 2015

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

scientific article published on August 1999

Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein

scientific article published on November 2002

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function

scientific article

Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide

scientific article published in November 1992

Erratum: Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

scientific article published in Nature

Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein

scientific article

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

scientific article

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

scientific article

Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes.

scientific article

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

scientific article published on June 2001

Functional immobilization of a ligand-activated G-protein-coupled receptor

scientific article published in October 2002

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

scientific article published on 24 April 2001

G protein coupled receptor structure and activation

scientific article published on 15 November 2006

G protein-coupled receptors. II. Mechanism of agonist activation

scientific article published in July 1998

G protein-coupled receptors: functional and mechanistic insights through altered gene expression

scientific article

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

scientific article

Gene targeting — homing in on α2-adrenoceptor-subtype function ⬇️

scientific article published on June 1, 1997

Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist

scientific article published in January 1997

Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels

scientific article published in September 1999

Genetic models of human vascular disease

scientific article published on January 1995

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

scientific article published on March 2013

Goniometer-based femtosecond crystallography with X-ray free electron lasers

scientific article

Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists

scientific article

High-density grids for efficient data collection from multiple crystals

scientific article

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

scientific article

High-resolution crystal structure of human protease-activated receptor 1

scientific article

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies

scientific article published on 11 March 2016

How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling

scientific article published on 08 December 2020

Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes

scientific article (publication date: July 1988)

Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes

article

Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach

scientific article

Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors

scientific article published on April 1992

Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor

scientific article published on 29 October 2002

Identification of intramolecular interactions in adrenergic receptors

scientific article published on November 1992

Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM.

scientific article

Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape

scientific article published on 13 July 2015

In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures

scientific article

Insights from in vivo modification of adrenergic receptor gene expression

scientific article published in January 1998

International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?

scientific article published in October 2010

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor

scientific article

Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand

scientific article published on August 1997

Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception

scientific article published in February 2002

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length.

scientific article published on 7 November 2016

Ligand stabilization of the beta 2 adrenergic receptor: effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy

scientific article published in November 1996

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors

scientific article

Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer

scientific article published on 17 September 2009

Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor

scientific article published on 28 June 2012

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

scientific article

Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5.

scientific article

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

scientific article

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

scientific article

Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells

scientific article

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.

scientific article

Mechanism of β2AR regulation by an intracellular positive allosteric modulator

scientific article published on 27 June 2019

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

scientific article

Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis

scientific article published on 23 October 2014

Molecular Biology of Adrenergic Receptors

scientific article published on 01 January 1988

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor

scientific article

Molecular determinants of ligand efficacy and potency in GPCR signaling

scientific article published on 21 December 2023

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells

scientific article

Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development

scientific article

Muscarinic acetylcholine receptors: novel opportunities for drug development

scientific article

Muscarinic receptors as model targets and antitargets for structure-based ligand discovery

scientific article published on 25 July 2013

Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.

scientific article published in October 2002

Myocyte adrenoceptor signaling pathways

scientific article

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

scientific article

N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes.

scientific article published on 17 May 2007

Nanobodies to Study G Protein-Coupled Receptor Structure and Function

scientific article

Nanobody stabilization of G protein-coupled receptor conformational states.

scientific article

Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes

scientific article published on 3 August 2014

Neuropeptide Y receptor 1 (NPY-Y1) expression in human heart failure and heart transplantation

scientific article

New G-protein-coupled receptor crystal structures: insights and limitations

scientific article published on 14 January 2008

New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability

scientific article published on 05 June 2020

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

scientific article

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

scientific article

Novel insights into M3 muscarinic acetylcholine receptor physiology and structure

scientific article published on 26 September 2013

Novel tripod amphiphiles for membrane protein analysis

scientific article published on 02 October 2013

Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes

scientific article

Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

scientific article

PDZ-domain arrays for identifying components of GPCR signaling complexes

scientific article published on 09 August 2006

Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization

scientific article published on 06 June 2020

Pharmacological sequestration of a chimeric beta 3/beta 2 adrenergic receptor occurs without a corresponding amount of receptor internalization

scientific article published on January 1, 1996

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

scientific article published on 24 April 2017

Phosphodiesterase 4D disruption causes β2 adrenergic receptors to behave like β1 adrenergic receptors in vivo.

scientific article

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes

scientific article

Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization

scientific article published on 26 January 2006

Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor

scientific article published in March 2004

Primary structure of the mouse beta 1-adrenergic receptor gene

scientific article published on September 1993

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

scientific article published on 7 April 2005

Propagation of conformational changes during μ-opioid receptor activation

scientific article published on 5 August 2015

Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart

scientific article published in April 2004

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

scientific article published on 01 February 2019

Q&A: Brian Kobilka. Stuck on structure

scientific article published in October 2014

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

scientific article published on 21 September 2018

Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein

scientific article published on July 1998

Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal

scientific article

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

scientific article published on 06 December 2013

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

scientific article published in Nature

Reply

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.

scientific article

Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity

scientific article published on September 1998

Restricting the mobility of Gs alpha: impact on receptor and effector coupling

scientific article published on October 1999

Role of detergents in conformational exchange of a G protein-coupled receptor

scientific article

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins

scientific article

Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs

scientific article published on 01 August 2019

Selective modulation of the cannabinoid type 1 (CB1) receptor as an emerging platform for the treatment of neuropathic pain

scientific article published on 18 March 2019

Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

scientific article published on 05 August 2019

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

scientific article published on 10 April 2019

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

scientific article

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

scientific journal article

Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

scientific article published on 01 July 2018

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

scientific article published on 07 June 2017

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

scientific article

Site-specific fluorescence labeling of the beta2 adrenergic receptor amino terminus

scientific article

Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor

scientific article

Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability.

scientific article published on 16 April 2018

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

scientific article published on 14 May 2015

Structural Insights into the Process of GPCR-G Protein Complex Formation

scientific article published on 09 May 2019

Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist

scholarly article by Patrizia M. Spoerri published in June 2018

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

scientific article published in April 2017

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

scientific article published on 11 November 2020

Structural determinants of dual incretin receptor agonism by tirzepatide

scientific article published on 25 March 2022

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

scientific article

Structural insights into G-protein-coupled receptor activation

scientific article published on 17 November 2008

Structural insights into adrenergic receptor function and pharmacology

scientific article published on 15 March 2011

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

scientific article

Structural insights into differences in G protein activation by family A and family B GPCRs

scientific article

Structural insights into probe-dependent positive allosterism of the GLP-1 receptor

scientific article published on 20 July 2020

Structural insights into the activation of metabotropic glutamate receptors

scientific article published on 23 January 2019

Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor

scientific article published on 12 November 2018

Structural insights into µ-opioid receptor activation

scientific article

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

scientific article published on January 1997

Structural mechanisms of selectivity and gating in anion channelrhodopsins

scientific article published in Nature

Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies

scientific article

Structure and dynamics of GPCR signaling complexes.

scientific article published on 8 January 2018

Structure and dynamics of the M3 muscarinic acetylcholine receptor

scientific article

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

scientific article

Structure and selectivity engineering of the M1 muscarinic receptor toxin complex

scientific article

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

scientific article published on 10 January 2019

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

scientific article

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

scientific article

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

scientific article

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

scientific article published on 16 January 2020

Structure of the µ-opioid receptor–Gi protein complex

scientific article published in Nature

Structure of the δ-opioid receptor bound to naltrindole

scientific article

Structure-based discovery of beta2-adrenergic receptor ligands

scientific article

Structure-based discovery of opioid analgesics with reduced side effects

scientific article

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor

scientific article published on 16 February 2018

Structure-based drug screening for G-protein-coupled receptors

scientific article published on 13 April 2012

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms

scientific article published on 02 March 2020

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

scientific article

Subtype-specific differences in the intracellular sorting of G protein-coupled receptors ⬇️

scientific article published on January 15, 1993

Subtype-specific intracellular trafficking of alpha2-adrenergic receptors

scientific article published on May 1997

Tandem facial amphiphiles for membrane protein stabilization

scientific article

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

scientific article

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

scientific article published on October 2016

Targeted disruption of the beta2 adrenergic receptor gene

scientific journal article

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects

scientific journal article

Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.

scientific article

The Molecular Basis of G Protein-Coupled Receptor Activation.

scientific article published in June 2018

The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes

scientific article published on 3 July 2002

The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes

scientific article

The Third Intracellular Loop and the Carboxyl Terminus of β2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor ⬇️

scientific article published on November 1, 2003

The cubicon method for concentrating membrane proteins in the cubic mesophase

scientific article published on 3 August 2017

The developmental and physiological consequences of disrupting genes encoding beta 1 and beta 2 adrenoceptors.

scientific article

The dynamic process of β(2)-adrenergic receptor activation

scientific article published on January 2013

The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors

scientific article

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

scholarly article

The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor

scientific journal article

The new biology of drug receptors

scientific article

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis

scientific article published on February 1994

The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system ⬇️

scientific article published on 01 May 1990

The role of ligands on the equilibria between functional states of a G protein-coupled receptor

scientific article published on 14 June 2013

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

scientific article published on 17 February 2014

The structural basis of G-protein-coupled receptor signaling (Nobel Lecture)

scientific article

The structure and function of G-protein-coupled receptors

scientific article (publication date: 21 May 2009)

Toward understanding GPCR dimers

scientific article published on 01 August 2004

Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop

scientific article published in September 1996

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

scientific article published on 01 March 2019

Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level

scientific article published in October 1989

Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission

scientific article

Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery

scientific article published on January 2009

Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor

scientific article

Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles

scientific article published on 01 August 2005

Viewing rare conformations of the β<sub>2</sub> adrenergic receptor with pressure-resolved DEER spectroscopy

scientific article published on 30 November 2020

Visualization of arrestin recruitment by a G-protein-coupled receptor

scientific article (publication date: 14 August 2014)

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

scientific article published on 22 March 2018

beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes

scientific article published on 01 December 2000

betaAR signaling required for diet-induced thermogenesis and obesity resistance

scientific article

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor

scientific article

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