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List of works by Ryszard Kole

An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models

scientific article published on 06 May 2008

Analysis of prostate-specific membrane antigen splice variants in LNCap cells

scientific article published on 01 January 2006

Anti-tumor activity of splice-switching oligonucleotides

scientific article

Applications of the PMO platform to genetic diseases.

scientific article published on 11 November 2015

Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents

scientific article

Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression

scientific article

Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids

scientific article

Dystromirs as serum biomarkers for monitoring the disease severity in Duchenne muscular Dystrophy

scientific article

Effects of base modifications on antisense properties of 2'-O-methoxyethyl and PNA oligonucleotides

scientific article published on January 2003

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

scientific article

Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice

scientific article published on 18 July 2006

Engineered U7 snRNA mediates sustained splicing correction in erythroid cells from β-thalassemia/HbE patients.

scientific article

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

scientific article

Exon skipping therapy for Duchenne muscular dystrophy

scientific article published on 14 May 2015

HIV-1 preferentially binds receptors copatched with cell-surface elastase

scientific article published on 21 August 2003

High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA.

scientific article published on 15 August 2002

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

scientific article

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers

scientific article

Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching

scientific article

Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells

scientific article published on February 2009

Modification of alternative splicing by antisense therapeutics

scientific article published on January 2004

Modulation of RNA splicing as a potential treatment for cancer ⬇️

scientific article published on May 1, 2011

Oligonucleotide therapeutics in cancer

scientific article

Peptide-morpholino conjugate: a promising therapeutic for Duchenne muscular dystrophy

scientific article published on 01 September 2009

Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping

scientific article

RNA modulation, repair and remodeling by splice switching oligonucleotides.

scientific article published in January 2004

RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice

scholarly article

Repair of a splicing defect in erythroid cells from patients with beta-thalassemia/HbE disorder

scientific article published on December 2002

Restoration of correct β-globin mRNA splicing and HbA production by engineered U7 snRNA in β-thalassaemia/HbE erythroid cells

scientific article published on 21 May 2019

Restoration of human beta-globin gene expression in murine and human IVS2-654 thalassemic erythroid cells by free uptake of antisense oligonucleotides.

scientific article

Self-aggregating 1.8kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon-skipping oligonucleotides

scientific article published on 9 December 2016

Short-term and long-term modulation of gene expression by antisense therapeutics

scientific article

Size-uniform 200 nm particles: fabrication and application to magnetofection

scientific article

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides.

scientific article

Splicing: hear and now!

scientific article published on May 2013

Superoxide-dependent iron uptake: a new role for anion exchange protein 2.

scientific article

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

scientific article published on 10 June 2008

Switching on transgene expression by correcting aberrant splicing using multi-targeting steric-blocking oligonucleotides

scientific article published on 01 June 2007

Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids

scientific article

Targeted exon skipping to address "leaky" mutations in the dystrophin gene.

scientific article

Targeting mRNA splicing as a potential treatment for Duchenne muscular dystrophy

scientific article published on July 1, 2012

The importance of Bcl-xL in the survival of human RPE cells

scientific article published on 01 August 2007

Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

scientific article

Therapeutic potential of splice-switching oligonucleotides

scientific article published on March 2009

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