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List of works by Torgeir Flatmark

A Kinetic and Conformational Study on the Interaction of Tetrahydropteridines with Tyrosine Hydroxylase†

scientific article published in November 2000

A comparison of kinetic and regulatory properties of the tetrameric and dimeric forms of wild-type and Thr427-->Pro mutant human phenylalanine hydroxylase: contribution of the flexible hinge region Asp425-Gln429 to the tetramerization and cooperativ

scientific article

A general and rational approach to the optimal recovery of mitochondria by differential centrifugation in homogenous media ⬇️

scientific article published on May 26, 1975

A low-cost integrator for preparative ultracentrifuges ⬇️

scientific article published on March 1, 1974

Acyl-CoA synthetase activity of brown adipose tissue mitochondria substrate specificity and its relation to the endogenous pool of long-chain fatty acids ⬇️

scientific article published on July 14, 1980

Acyl-CoA synthetase activity of rat heart mitochondria. Substrate specificity with special reference to very-long-chain and isomeric fatty acids

scientific article published on August 1983

Acyl-CoA synthetase activity of rat liver microsomes. Substrate specificity with special reference to very-long-chain and isomeric fatty acids

scientific article published on 01 May 1981

Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation

scientific article published on 08 June 2007

An adenosine 3':5'-monophosphate-adenosine binding protein from mouse liver: some physicochemical properties

scientific article published on March 1978

Anion- and pH-dependent activation of the soluble form of dopamine beta-hydroxylase

scientific article published on February 2003

Annexin A2 recognises a specific region in the 3'-UTR of its cognate messenger RNA

scientific article published on 01 September 2006

Ascorbate as a natural constituent of chromaffin granules from the bovine adrenal medulla ⬇️

scientific article published on 01 November 1975

Binding of ATP at the active site of human pancreatic glucokinase – nucleotide‐induced conformational changes with possible implications for its kinetic cooperativity ⬇️

scientific article published on May 31, 2011

Brown adipose tissue mitochondria ⬇️

scientific article published on March 31, 1975

Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions

scientific article

Characterization of a novel pterin intermediate formed in the catalytic cycle of tyrosine hydroxylase

scientific article

Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla

scientific article published on 01 July 1987

Characterization of the iron environment in recombinant human tyrosine hydroxylase, using Mössbauer and EPR-spectroscopy

scientific article published on 01 January 1993

Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR

scientific article published on 29 June 1993

Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation

scientific article published on 01 August 1996

Conjugation of phenylalanine hydroxylase with polyubiquitin chains catalysed by rat liver enzymes.

scientific article published in June 2001

Cooperative homotropic interaction of l-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase

scientific article published in October 1990

Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase

scientific article

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

scientific article

Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase

scientific article published in April 1997

Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution

scientific article published on 10 November 1998

Cytochrome -561 of the bovine adrenal chromaffin granules. Molecular weight and hydrodynamic properties in micellar solutions of Triton X-100 ⬇️

scientific article published on March 16, 1981

Cytochrome b 561 of the bovine adrenal chromaffin granules. A high potential b-type cytochrome

scientific article

Cytochrome b-561 as the single heme protein of the bovine adrenal chromaffin granule membrane

scientific article

Deamidations in recombinant human phenylalanine hydroxylase. Identification of labile asparagine residues and functional characterization of Asn --> Asp mutant forms

scientific article

Determination of CoASH by high-performance liquid chromatography and its application in the assay of long-chain acyl-CoA derivatives ⬇️

scientific article published on 01 July 1979

Determination of sedimentation coefficients of subcellular particles of rat liver homogenates. A theoretical and experimental approach

scientific article published in December 1973

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease

scientific article

Domain structure and stability of human phenylalanine hydroxylase inferred from infrared spectroscopy

scientific article published on 30 January 1998

Dopamine Oxidation Generates an Oxidative Stress Mediated by Dopamine Semiquinone and Unrelated to Reactive Oxygen Species ⬇️

scientific article published on June 1, 1997

Dopamine beta-monooxygenase. Binding to apoenzyme and rapid exchange in holoenzyme of 64Cu studied with high-performance size-exclusion gel chromatography

scientific article published in April 1983

Dopamine beta-monooxygenase: reduced enzyme needs additional reductant for completion of the catalytic cycle

scientific article published on September 14, 1978

EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors

scientific article published in June 1991

Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver

scientific article published on 01 January 1987

Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet

scientific article published on 01 March 1986

Electron Paramagnetic Resonance of the Copper in Dopamine beta-Monooxygenase. Rapid Reduction by Ascorbate, the Steady-State Redox Level, Chelation with EDTA, and Reactivation of the Apoenzyme by Added Copper ⬇️

scientific article published on 01 January 1980

Electron carriers of the bovine adrenal chromaffin granules

scientific article published on 01 January 1971

Electron carriers of the noradrenaline storage vesicles from bovine splenic nerves

scientific article published on 01 August 1971

Energy-dependent accumulation of calcium antagonists in catecholamine storage vesicles

scientific article published on 01 January 2000

Energy-dependent accumulation of iron by isolated rat liver mitochondria V. Effect on factors controlling respiration and oxidative phosphorylation ⬇️

scientific article published on April 14, 1975

Energy-dependent accumulation of iron by isolated rat liver mitochondria. 3. Submitochondrial localization of the iron accumulated

scientific article published in May 1974

Energy-dependent accumulation of iron by isolated rat liver mitochondria. I. General features.

scientific article

Energy-dependent accumulation of iron by isolated rat liver mitochondria. II. Relationship to the active transport of Ca2+ ⬇️

scientific article published on October 19, 1973

Energy-dependent redox reactions of two b-type cytochromes in brown adipose tissue mitochondria ⬇️

scientific article published on October 19, 1973

Evidence for a negative modulating effect of erucic acid on the peroxisomal beta-oxidation enzyme system and biogenesis in rat liver

scientific article published on 01 October 1983

Evidence from EPR spectroscopy that phosphorylation of Ser-40 in bovine adrenal tyrosine hydroxylase facilitates the reduction of high-spin Fe(III) under turnover conditions

scientific article published on 20 November 1989

Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme

scientific article

Expression of wild type and mutant forms of human phenylalanine hydroxylase in E. coli.

scientific article

Fluorometric detection of tryptophan, 5-hydroxytryptophan, and 5-hydroxytryptamine (serotonin) in high-performance liquid chromatography

scientific article published on 01 September 1980

GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation

scientific article published on 31 August 2013

GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation

scientific article

Generation of reactive oxygen species by tyrosine hydroxylase: a possible contribution to the degeneration of dopaminergic neurons?

scientific article published on 01 January 1997

Heterotetrameric forms of human phenylalanine hydroxylase: Co-expression of wild-type and mutant forms in a bicistronic system ⬇️

scientific article published on February 17, 2011

High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin ⬇️

scientific article published on November 23, 2001

High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase

scientific article published in November 1991

Hydrodynamic parameters and isolation of mitochondria, microperoxisomes and microsomes of rat heart

scientific article published on 01 December 1982

Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid

scientific article published on 01 July 1989

Inactivation of purified phenylalanine hydroxylase by dithiothreitol

scientific article published in January 1992

Increase in mitochondrial content of long-chain acyl-CoA in brown adipose tissue during cold-acclimation

scientific article published in July 1984

Inhibition byN-ethylmaleimide of the MgATP-driven proton pump of the chromaffin granules ⬇️

scientific article published on November 22, 1982

Inhibition of aromatic L-amino acid decarboxylase activity by human autoantibodies

scientific article published in June 2000

Inhibition of dopamine beta-mono-oxygenase by non-ionic detergents of the triton X-series

scientific article published on April 1, 1977

Inhibition of the H+-ATPase in bovine adrenal chromaffin granule ghosts by diethylstilbestrol. Evidence for a tight coupling between ATP hydrolysis and proton translocation

scientific article published on 01 February 1988

Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by 1H-NMR

scientific article published on 01 January 1993

Isolation and characterization of noradrenalin storage granules of bovine adrenal medulla ⬇️

scientific article published on June 2, 1979

Isolation and characterization of tetrahydropterin oxidation products generated in the tyrosine 3-monooxygenase (tyrosine hydroxylase) reaction

scientific article

Isolation from the microsomal fraction of rat liver of a subfraction highly enriched in uncoated endocytic vesicles with high H+-ATPase activity and a 50 kDa phosphoprotein

scientific article published on 01 September 1985

Kinetic analysis and ligand-induced conformational changes in dimeric and tetrameric forms of human thymidine kinase 2.

scientific article

Long-chain acyl-CoA synthetase and "outer" carnitine long-chain acyltransferase activities of intact brown adipose tissue mitochondria

scientific article published on September 28, 1978

Microperoxisomes and mitochondria of brown adipose tissue. Hydrodynamic parameters, isolation and capacity of long-chain fatty acid oxidation

scientific article published in September 1982

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state ⬇️

scientific article published on 01 February 1980

Modulation by pterins of the phosphorylation and phenylalanine activation of phenylalanine 4-mono-oxygenase

scientific article published on March 1987

NADH(NADPH): (acceptor) oxidoreductase activities of the bovine adrenal chromaffin granules

scientific article published on 01 May 1973

NH2-terminal sequence of dopamine beta-hydroxylase from bovine adrenal medulla

scientific article published on February 21, 1977

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation

scientific article

On the mechanism of induction of the enzyme systems for peroxisomal beta-oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil

scientific article published on 01 September 1988

On the mechanism of stimulation of peroxisomal beta-oxidation in rat heart by partially hydrogenated fish oil

scientific article published on 01 March 1995

On the polydispersity of mitochondria in tissue homogenates and the determination of the average sedimentation coefficients of mixed populations of mitochondria ⬇️

scientific article published on October 15, 1978

On the rate-limiting step in the transfer of long-chain acyl groups across the inner membrane of brown adipose tissue mitochondria ⬇️

scientific article published on February 9, 1978

Oxidoreductase activities of chromaffin granule ghosts isolated from the bovine adrenal medulla

scientific article published on 01 April 1980

Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.

scientific article

Phenylalanine 4-monooxygenase from bovine and rat liver: some physical and chemical properties

scientific article published on 01 April 1982

Phenylalanine 4-monooxygenase from bovine liver

scientific article published on 01 January 1987

Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells

scientific article published on June 1990

Phenylalanine positively modulates the cAMP‐dependent phosphorylation and negatively modulates the vasopressin‐induced and okadaic‐acid‐induced phosphorylation of phenylalanine 4‐monooxygenase in intact rat hepatocytes ⬇️

scientific article published on May 15, 1992

Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation

scientific article published on 16 October 2010

Phosphatidylinositol kinase of bovine adrenal chromaffin granules. Modulation by hydrophilic and amphiphilic cations

scientific article published on 01 November 1988

Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+

scientific article published on 01 February 1988

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects

scientific article published on 15 August 2002

Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease

scientific article published on January 1996

Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis

scientific article published in April 2004

Purification and Characterization of Dopamine β ‐Hydroxylase from Bovine Adrenal Medulla ⬇️

scientific article published on January 15, 1976

Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40 ⬇️

scientific article published on June 15, 1992

Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medulla

scientific article published on 01 February 1990

Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions

scientific article published on 01 February 1989

Rapid and sensitive assay of tyrosine 3-monooxygenase activity by high-performance liquid chromatography using the native fluorescence of DOPA

scientific article published on 01 October 1980

Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene

scientific article

Recombinant human phenylalanine hydroxylase is a substrate for the ubiquitin-conjugating enzyme system

scientific article published on November 1996

Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions

scientific article published in July 1991

Regulation of recombinant human tyrosine hydroxylase isozymes by catecholamine binding and phosphorylation. Structure/activity studies and mechanistic implications.

scientific article published in October 1992

Relation between induction of ornithine decarboxylase and specific gene expression in rat liver in response to the tumor promoter agent clofibrate

scientific article published on 01 September 1986

Resonance Raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase). Evidence that the feedback inhibitors adrenaline and noradrenaline are coordinated to iron

scientific article published in December 1988

SUMOylation of pancreatic glucokinase regulates its cellular stability and activity

scientific article published on 7 January 2013

Sedimentation coefficient and buoyant density of brown adipose tissue mitochondria from guinea pigs ⬇️

scientific article published on May 12, 1975

Soluble tyrosine hydroxylase (tyrosine 3-monooxygenase) from bovine adrenal medulla: large-scale purification and physicochemical properties.

scientific article published on March 1988

Some aspects of the phosphorylation of phenylalanine 4-monooxygenase by a calcium-dependent and calmodulin-dependent protein kinase

scientific article published on 01 November 1984

Stereoselective effects in the interactions of pterin cofactors with rat-liver phenylalanine 4-monooxygenase

scientific article published on 01 October 1986

Structure of Tetrameric Human Phenylalanine Hydroxylase and Its Implications for Phenylketonuria ⬇️

scientific article published on July 3, 1998

Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.

scientific article

Studies on the energy state of isolated brown adipose tissue mitochondria the cytochrome b complex as a probe of the energy state of the mitochondrial inner membrane ⬇️

scientific article published on August 17, 1972

Studies on the energy state of isolated brown adipose tissue mitochondria. Effect of adenine nucleotides and oligomycin on the generation and dissipation of the "energy potential".

scientific article published in January 1973

Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration ⬇️

scientific article published on December 6, 1976

Subcellular distribution of ascorbate in bovine adrenal medulla. Evidence for accumulation in chromaffin granules against a concentration gradient

scientific article published on 01 March 1980

Substrate-induced conformational transition in human phenylalanine hydroxylase as studied by surface plasmon resonance analyses: the effect of terminal deletions, substrate analogues and phosphorylation

scientific article published on February 2003

Synergistic Antiproliferative Actions of Cyclic Adenosine 3′,5′-Monophosphate, Interleukin-1β, and Activators of Ca2+/Calmodulin-Dependent Protein Kinase in Primary Hepatocytes1 ⬇️

scientific article published on October 1, 1997

The PKU mutation S349P causes complete loss of catalytic activity in the recombinant phenylalanine hydroxylase enzyme.

scientific article

The assignment of the Ca2+-ATPase activity of chromaffin granules to the proton translocating ATPase

scientific article published on 01 March 1985

The cooperative binding of phenylalanine to phenylalanine 4-monooxygenase studied by 1H-NMR paramagnetic relaxation. Changes in water accessibility to the iron at the active site upon substrate binding

scientific article published on January 1993

The effect of calcium channel blockers on the H+-ATPase and bioenergetics of catecholamine storage vesicles ⬇️

scientific article published on May 25, 1991

The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme

scientific article published on 01 September 1984

The effect of phosphorylation at Ser-40 on the structure and thermal stability of tyrosine hydroxylase

scientific article published on 01 January 1998

The effect of prenylamine and organic nitrates on the bioenergetics of bovine catecholamine storage vesicles

scientific article published on 01 July 1990

The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase

scientific article published on 11 April 2001

The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy

scientific article published in November 1992

The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV

scientific article published on 07 March 2007

Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms

scientific article published on December 2003

Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection.

scientific article

Use of surface plasmon resonance for real-time measurements of the global conformational transition in human phenylalanine hydroxylase in response to substrate binding and catalytic activation

scientific article published in July 2001

pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40

scientific article published on 26 March 1990

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