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List of works by Sekhar Konjeti

Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway

scientific article published on 01 January 2008

Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.

scientific article published on 21 October 2010

Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation

scientific article

Clusterin as a therapeutic target for radiation sensitization in a lung cancer model.

scientific article published on November 2005

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

scientific article

Cysteine-based regulation of the CUL3 adaptor protein Keap1

scientific article

Hedgehog signaling in the murine melanoma microenvironment

scientific article published on 31 August 2007

Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas

scientific article published on 01 September 2006

Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature

scientific article

Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds

scientific article published on January 2011

Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells

scientific article published on October 2006

Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation

scientific article published on 01 November 2006

Loss of NRF2 impairs gastric nitrergic stimulation and function

scientific article

NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols

scientific article published in September 2003

NRF2 deficiency reduces life span of mice administered thoracic irradiation

scientific article

Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway

scientific article published on 01 January 2007

Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

scientific article published on 25 November 2006

Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents

scientific article published on 17 October 2007

Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.

scientific article

Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay.

scientific article published in October 2004

Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.

scientific article published in January 2005

Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway

scientific article published on 01 April 2019

Radiosensitization of cancer cells by hydroxychalcones

scientific article

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase

scientific article (publication date: April 2002)

Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.

scientific article

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

scientific article published on 28 June 2005

Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.

scientific article

The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development

scientific article

The antiangiogenic agent SU5416 down-regulates phorbol ester-mediated induction of cyclooxygenase 2 expression by inhibiting nicotinamide adenine dinucleotide phosphate oxidase activity

scientific article published in October 2003

The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins

scientific article published on 9 October 2012

The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization

scientific article

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