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List of works by Zhijian Chen

A GTPase-activating protein binding protein (G3BP1) / antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.

scientific article published on 6 April 2018

A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.

scientific article published on 4 February 2014

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

scientific article

A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis

scientific article published on 3 January 2014

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

scientific article published on October 2009

A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma ⬇️

scientific article published on January 24, 2012

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

scientific article

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

scientific article (publication date: 21 April 2006)

Activation of the interferon-beta promoter during hepatitis C virus RNA replication.

scientific article

Antiviral innate immunity pathways.

scientific article

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

scientific article

Author Correction: STEEP mediates STING ER exit and activation of signaling

scientific article published on 14 September 2020

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

scientific article published on 06 March 2019

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.

scientific article

Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling

scientific journal article

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.

scientific article published on 18 February 2013

Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses ⬇️

scientific article published on January 27, 2011

Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.

scientific article published on August 2008

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

scientific article

Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity

scientific article published on 28 August 2015

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

scientific article published on 06 March 2019

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

scientific article

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

scientific article published on 2 June 2015

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

scientific journal article

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

scientific article

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

scientific article

Cyclic di-GMP sensing via the innate immune signaling protein STING

scientific article

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

scientific article published in February 2018

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

scientific article published on 05 July 2018

Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.

scientific article published on 23 March 2012

Direct activation of protein kinases by unanchored polyubiquitin chains

scientific article

Diversity of polyubiquitin chains.

scientific article published in April 2009

E1-L2 activates both ubiquitin and FAT10

scientific article

Editorial overview: Innate immunity

scientific article published on 07 February 2015

Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1.

scientific article

Emerging Role of ISG15 in Antiviral Immunity ⬇️

scientific article published on October 15, 2010

Endocytic pathway is required for Drosophila Toll innate immune signaling

scientific article

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

scientific article

Essential role of TAK1 in thymocyte development and activation.

scholarly article

Expanding role of ubiquitination in NF-κB signaling ⬇️

scientific article published on 07 December 2010

Getting to grips with hepatitis.

scientific article

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

scientific article

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

scientific article published on 27 May 2016

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

scientific article

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

scientific article published on November 2002

Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS

scientific article

IKKβ is an IRF5 kinase that instigates inflammation

scientific article

IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

scientific article published on 28 February 2013

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

scientific article (publication date: 9 September 2005)

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

scientific article

Innate immune sensing and signaling of cytosolic nucleic acids

scientific article published on January 2014

Intrinsic antiviral immunity

scientific article (publication date: 16 February 2012)

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

scientific article published on June 2016

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

scientific article

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3

scientific article

Linking retroelements to autoimmunity

scientific article published on 01 August 2008

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

scientific article

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

scientific article

Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.

scientific article published on 6 July 2015

Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication

scientific article

NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK

scientific article

Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.

scientific article published on 2 September 2016

Nonproteolytic functions of ubiquitin in cell signaling

scientific article (publication date: 13 February 2009)

Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction.

scientific article published on 15 December 2003

Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation

scientific article

Peroxisomes are signaling platforms for antiviral innate immunity

scientific article

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

scientific article

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

scientific article

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

scientific article

Prion-Like Polymerization in Immunity and Inflammation.

scientific article published on 23 November 2016

Prion-like polymerization as a signaling mechanism

scientific article

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

scientific article

RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge

scientific article published on 13 February 2013

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

scientific article

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

scientific article

Regulation of NF-κB by ubiquitination ⬇️

scientific article published on January 8, 2013

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination

scientific article

STEEP mediates STING ER exit and activation of signaling

scientific article published on 20 July 2020

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

scientific article

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

scientific article

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

scientific article

SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference.

scientific article published in April 2010

Sequence specific detection of bacterial 23S ribosomal RNA by TLR13 ⬇️

scientific article published on October 30, 2012

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

scientific article

Smads keep TABs on inflammation

scientific article published on 01 May 2007

Sorting out Toll signals.

scientific article

Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

scientific article

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

scientific article

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

scientific article

Structural basis of STING binding with and phosphorylation by TBK1

scientific article published on 06 March 2019

Structural insights into the activation of RIG-I, a nanosensor for viral RNAs

scientific article published on 23 December 2011

Synthetic nanovaccines for immunotherapy.

scientific article published on 20 March 2017

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

scientific article

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

scientific article

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

scientific article published on 11 April 2017

TRAF2: a double-edged sword?

scientific article

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

scientific article

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

scientific article

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer

scientific article published on 05 April 2018

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling

scientific article

The role of ubiquitin in NF-kappaB regulatory pathways.

scientific article published on January 2009

The role of ubiquitylation in immune defence and pathogen evasion

scientific article

Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems.

scientific article

Ubiquitin in NF-kappaB signaling.

scientific article published on April 2009

Ubiquitin signalling in the NF-kappaB pathway

scientific article (publication date: August 2005)

Ubiquitin-dependent activation of NF-kappaB: K63-linked ubiquitin chains: a link to cancer?

scientific article published on 12 March 2004

Ubiquitination in signaling to and activation of IKK.

scientific article published on March 2012

Ubiquitylation in innate and adaptive immunity.

scientific article published on March 2009

Viperin Links Lipid Bodies to Immune Defense ⬇️

scientific article published on March 25, 2011

cGAS in action: Expanding roles in immunity and inflammation

scientific article

cGAS is essential for cellular senescence

scientific article

cGAS suppresses genomic instability as a decelerator of replication forks

scientific article published on 14 October 2020

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