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List of works by Roberta F. Colman

A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase

scientific article

A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A.

scientific article published on 3 April 2008

A nonhydrolyzable reactive cAMP analogue, (S(p))-8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic S-(methyl)monophosphorothioate, irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase at micromolar concentrations

scientific article published on March 2002

Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts

scientific article published on 13 August 2010

Adenosine 2'-monophosphate, 5'-O-[S-(4-succinimidylbenzophenone)-thiophosphate]: a new photoaffinity label for the coenzyme site of porcine NADP-specific isocitrate dehydrogenase

scientific article published in May 2005

Adenylosuccinate lyase deficiency

scientific article

Affinity labeling and related approaches to targeting specific enzyme sites

scientific article published on January 1995

Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants

scientific article

Catalytically active monomer of glutathione S-transferase pi and key residues involved in the electrostatic interaction between subunits

scientific article published on 16 September 2008

Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role

scientific article (publication date: 25 February 2003)

Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin

scientific article published on 10 March 2008

Communication between the two active sites of glutathione S-transferase A1-1, probed using wild-type-mutant heterodimers

scientific article published in June 2005

Contribution of the mu loop to the structure and function of rat glutathione transferase M1-1.

scientific article published on 2 May 2006

Critical Role of Lys212 and Tyr140 in Porcine NADP-dependent Isocitrate Dehydrogenase ⬇️

scientific article published on September 25, 2003

Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism

scientific article

Delineation of xenobiotic substrate sites in rat glutathione S-transferase M1-1.

scientific article published in October 2005

Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes

scientific article published in January 2006

Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function

scientific article

Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase

scientific article published on 28 June 2007

Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens

scientific article

Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase

scientific article

Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase

scientific article published in April 2002

Evaluation of types of interactions in subunit association in Bacillus subtilis adenylosuccinate lyase

scientific article

Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase

scientific article

GSTpi modulates JNK activity through a direct interaction with JNK substrate, ATF2 ⬇️

scientific article published on March 23, 2011

Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis

scientific article

Glutathione S-transferase Pi has at least three distinguishable xenobiotic substrate sites close to its glutathione-binding site

scientific article published on 3 September 2004

Heterodimers of wild-type and subunit interface mutant enzymes of glutathione S-transferase A1-1: interactive or independent active sites?

scientific journal article

Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase

scientific article

Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi

scientific article published on 01 October 2006

Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase

scientific article

Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase

scientific article published on March 2007

In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes

scientific article published on 3 February 2011

Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

scientific journal article

Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis

scientific article published in March 2004

Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase

scientific article

Monobromobimane occupies a distinct xenobiotic substrate site in glutathione S‐transferase π ⬇️

scientific article published on November 1, 2003

New insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A: a role for the unique 44-amino acid insert

scientific article published on 27 July 2006

Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase

scientific article

Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase

scientific article published on 2 December 2004

Substrate and Product Complexes of Escherichia coli Adenylosuccinate Lyase Provide New Insights into the Enzymatic Mechanism

scientific article

Subunit interface residues of glutathione S-transferase A1-1 that are important in the monomer-dimer equilibrium

scientific article published in March 2004

The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies

scientific article

Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required

scientific article (publication date: 19 February 2002)

Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL

scientific article

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