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List of works by Luqin Si

A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis

scientific article published on 13 August 2019

Accurate determination of a novel vasodilatory β-blocker TJ0711 using LC-MS/MS: resolution of an isobaric metabolite interference in dog plasma.

scientific article

Calcium pectinate gel bead intended for oral protein delivery: preparation improvement and formulation development

scientific article published on 01 July 2009

Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism.

scientific article

Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism.

scientific article

Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by liquid chromatography-tandem mass spectrometry.

scientific article published on 28 August 2017

Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion

scientific article published on 20 October 2010

In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay ⬇️

scientific article published on 01 January 2011

In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes.

scientific article

In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method

scientific article published on 21 February 2012

In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method

scientific article published on 10 September 2011

Influence of dose and route of administration on the enantioselective pharmacokinetics of TJ0711 hydrochloride in rats

scientific article published on 15 October 2014

Inhibitive effect of cremophor RH40 or tween 80-based self-microemulsiflying drug delivery system on cytochrome P450 3A enzymes in murine hepatocytes.

scientific article published on October 2010

Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation w

scientific article published on 20 April 2011

LC-MS/MS analysis of pramipexole in mouse plasma and tissues: elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction

scientific article published on 2 March 2015

LC-MS/MS assay of ropinirole in rat biological matrices: elimination of lysoglycerophosphocholines-based matrix effect.

scientific article

Nitric oxide releasing d-α-tocopheryl polyethylene glycol succinate for enhancing antitumor activity of doxorubicin.

scientific article published on 29 September 2014

Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo.

scientific article published on 8 November 2008

Oral Bioavailability of Kinsenoside in Beagle Dogs Measured by LC-MS/MS: Improvement of Ex Vivo Stability of a Lactone-Containing Compound

scientific article published on 09 July 2018

PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation.

scientific article published on 3 February 2015

Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes

scientific article published in February 2017

Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood

scientific article published in January 2015

Simultaneous LC-MS/MS bioanalysis of etoposide and paclitaxel in mouse tissues and plasma after oral administration of self-microemulsifying drug delivery systems

scientific article published on 19 January 2018

Simultaneous Quantitation of a Novel α₁/β₁-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion

scientific article published on 18 January 2019

Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug.

scientific article

Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry

scientific article

The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems.

scientific article published on 21 March 2011

The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues

scientific article

The sub-chronic impact of mPEG2k-PCLx polymeric nanocarriers on cytochrome P450 enzymes after intravenous administration in rats

scientific article published on 18 June 2019

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