Search filters

List of works by Sook Wah Yee

A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin

scientific article published on 14 July 2016

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype

scientific article

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing ⬇️

scientific article published on January 26, 2011

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update ⬇️

scientific article published on January 17, 2013

Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.

scientific article

Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).

scientific article

Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.

scientific article published on 8 March 2011

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

scientific article

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group ⬇️

scientific article published on September 25, 2012

Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits

scientific article published on 25 April 2019

Functional characterization of liver enhancers that regulate drug-associated transporters.

scientific article published on 2 March 2011

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes.

scientific article published on 12 April 2018

Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3 ⬇️

scientific article published on January 10, 2012

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.

scientific article

Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation ⬇️

scientific article

Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol

scientific article published on 23 May 2019

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

scientific article published on 6 April 2015

Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration

scientific article published on 03 June 2016

Genomic Characterization of Metformin Hepatic Response

scientific article

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

scientific article published in 2024

Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective from the International Transporter Consortium.

scientific article published on 21 April 2018

Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells.

scientific article published on 14 February 2006

International Transporter Consortium commentary on clinically important transporter polymorphisms.

scientific article published in July 2013

Membrane transporters in drug development

scientific article (publication date: March 2010)

Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.

scientific article published on 22 July 2016

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).

scientific article published on 3 November 2015

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

article

New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine

scientific article published on 10 August 2017

Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays.

scientific article published on November 2005

OCT1 in hepatic steatosis and thiamine disposition

scientific article published in January 2015

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

scientific article

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

scientific article published on 13 April 2019

Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP

scientific article

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

scientific article published on 16 April 2018

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue

scientific article published on 17 January 2019

Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

scientific article published on 6 April 2010

Pharmacogenetics of Antidiabetic Drugs

scientific article published on 14 May 2018

Pharmacogenomics of membrane transporters: past, present and future

scientific article published on April 2010

Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans

scientific article published on 14 June 2016

Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.

scientific article published in February 2006

Prediction and validation of enzyme and transporter off-targets for metformin.

scientific article published on 3 September 2015

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.

scientific article published on 23 December 2015

Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)

scientific article

SLC classification: an update

scientific article

SLC transporters as therapeutic targets: emerging opportunities

scientific article

SLC19A1 pharmacogenomics summary ⬇️

scientific article published on November 1, 2010

Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.

scientific article published on 9 June 2010

Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.

scientific article published on 3 February 2006

Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin

scientific article published on 28 April 2015

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin

scientific article published on 23 November 2015

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.

scientific article published on 17 October 2012

The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.

scientific article

The role of ATM in response to metformin treatment and activation of AMPK.

scientific article published on 28 March 2012

The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.

scientific article

Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines

scientific article published on 09 February 2016

Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

article

Unveiling the Genetic Architecture of Human Disease for Precision Medicine

scientific article published on 26 November 2018

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

scientific article

Paulina is supported by:

About Paulina

Help