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List of works by Elizabeth W Bradley

DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes

scientific article published on 18 May 2018

Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

scientific article published on 12 June 2019

Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.

scientific article published on 7 May 2015

Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

scientific article

Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development

scientific article published on 7 August 2017

Histone Deacetylases in Bone Development and Skeletal Disorders.

scientific article

Histone deacetylase 3 is required for maintenance of bone mass during aging

scientific article

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

scientific article

Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes.

scientific article published on 23 September 2016

Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion

scientific article published on 13 February 2013

Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification

scientific article

Identification of differentially methylated regions in new genes associated with knee osteoarthritis.

scientific article

Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity

scientific article published on 25 August 2017

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

scientific article published in Journal of Biological Chemistry

Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway.

scientific article

Osteoclast culture and resorption assays

scientific article published on 01 January 2008

PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival

scientific article

Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

scientific article

Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis.

scientific article published on 30 December 2015

Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

scientific article published on 03 October 2019

Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.

scientific article

TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

scientific article

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

scientific article

Transforming growth factor-{beta} coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis.

scientific article

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

scientific article published on 10 August 2016

WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways.

scientific article published on 23 June 2010

Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway.

scientific article published in June 2011

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