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List of works by Laia Tolosa

A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.

scientific article

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

scientific article published on 15 April 2016

Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.

scientific article published in January 2017

Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea

scientific article published on 30 August 2018

Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons.

scientific article

Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?

scientific article

Competency of different cell models to predict human hepatotoxic drugs

scientific article

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

scientific article published on 31 July 2017

Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.

scientific article

Fatty acid sensor for low-cost lifetime-assisted ratiometric sensing using a fluorescent fatty acid binding protein.

scientific article published in October 2005

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

scientific article published on 9 February 2013

Hepatocyte transplantation program: Lessons learned and future strategies

scientific article

High-Content Imaging Technology for the Evaluation of Drug-Induced Steatosis Using a Multiparametric Cell-Based Assay ⬇️

scientific article published on November 23, 2011

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

scientific article published on 27 August 2014

High-content screening technology for studying drug-induced hepatotoxicity in cell models.

scientific article published on 19 March 2015

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

scientific article published on 4 May 2016

Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.

scientific article published on 20 June 2016

Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat.

scientific article published in June 2015

Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

scientific article published on 13 November 2018

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project.

scientific article published on 23 July 2010

Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.

scientific article published on 22 December 2015

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

scientific article published on 25 January 2017

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

scientific article published on 27 June 2019

Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells

scientific article published on 25 July 2019

Steatotic liver: a suitable source for the isolation of hepatic progenitor cells

scientific article published on 01 September 2011

Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury

scientific article published on 19 February 2019

Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH₂

scientific article published on 17 May 2012

TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB

scientific article published on 16 September 2010

The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example

scientific article published on 25 May 2021

Transplantation of hESC-derived hepatocytes protects mice from liver injury

scientific article

Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants.

scientific article published on 27 May 2009

Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

scientific article published on 27 September 2016

Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment ⬇️

scientific article published on November 25, 2011

Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.

scientific article published on 11 December 2016

Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition.

scientific article published on 8 November 2008

Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase.

scientific article published on 25 December 2007

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