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List of works by Ralf Jauch

A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes

scientific article

A unique Oct4 interface is crucial for reprogramming to pluripotency

scientific article

Assessment of CASP7 structure predictions for template free targets

scientific article

Cancer-associated missense mutations enhance the pluripotency reprogramming activity of OCT4 and SOX17

scientific article published on 17 October 2019

Capturing the interactome of newly transcribed RNA.

scientific article published on 12 February 2018

Cell fate reprogramming through engineering of native transcription factors

scientific article published on 03 July 2018

Changing POU dimerization preferences converts Oct6 into a pluripotency inducer

scientific article published on 22 December 2016

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

scientific journal article

Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers

scientific article published on 03 April 2013

Conversion of Sox17 into a pluripotency reprogramming factor by reengineering its association with Oct4 on DNA

scientific article published on 01 June 2011

Coop-Seq Analysis Demonstrates that Sox2 Evokes Latent Specificities in the DNA Recognition by Pax6.

scientific article

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog

scientific article

Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA

scientific article

Crystallization and preliminary X-ray diffraction analysis of the Pax9 paired domain bound to a DC5 enhancer DNA element.

scientific article

DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors.

scientific article published on 10 January 2015

DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1.

scientific article published on 14 April 2018

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements ⬇️

scientific article published on February 16, 2012

Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing

scientific article published on 02 August 2018

Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency.

scientific article published on 28 August 2015

Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.

scientific article published on 15 January 2018

Evolution of the vertebrate gene regulatory network controlled by the transcriptional repressor REST. ⬇️

scientific article

Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors

scientific article published on 19 July 2014

Identification of a Polyoxometalate Inhibitor of the DNA Binding Activity of Sox2

scientific article published on 07 March 2011

Identification of a Wells-Dawson polyoxometalate-based AP-2γ inhibitor with pro-apoptotic activity

scientific article published on 11 June 2018

JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency

scientific article published on 08 October 2020

Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1.

scientific article published on 11 December 2015

LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration

scientific journal article

Molecular basis for the genome engagement by Sox proteins

scientific article

Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies.

scientific article published on 24 January 2018

OCT4: A penetrant pluripotency inducer.

scientific article published on 31 March 2014

Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

scientific article published on 8 March 2013

Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome

scientific article published on 24 July 2019

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

scientific article published on 31 January 2017

Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

scientific article published on 02 August 2019

Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq.

scientific article published on 02 December 2016

Rational Structure-Based Design of Bright GFP-Based Complexes with Tunable Dimerization

scientific article

Reprogramming cells with synthetic proteins

scientific article

SOX17 in cellular reprogramming and cancer

scientific article published on 13 August 2019

SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms

scientific article published in 2022

SOXE neofunctionalization and elaboration of the neural crest during chordate evolution.

scientific article published on 13 October 2016

SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains

scientific article published on 27 May 2015

Scientists and societies. Horizons in molecular biology

scientific article published on 01 February 2005

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

scientific article

Structural basis for the SOX-dependent genomic redistribution of OCT4 in stem cell differentiation.

scientific article published on 7 August 2014

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

scientific journal article

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction

scientific article published on 2 March 2016

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-  effectors

scientific article

Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.

scientific article published on 7 February 2005

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.

scientific article published on 16 April 2018

The Crystal Structure of a Maxi/Mini-Ferritin Chimera Reveals Guiding Principles for the Assembly of Protein Cages.

scientific article published on 6 July 2017

The crystal structure of the Sox4 HMG domain–DNA complex suggests a mechanism for positional interdependence in DNA recognition ⬇️

scientific article published on April 1, 2012

The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms

scientific article

TherMos: Estimating protein-DNA binding energies from in vivo binding profiles

scientific article published on 16 April 2013

What makes a pluripotency reprogramming factor?

scientific article published on June 2013

glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data

scientific article

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