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List of works by Xihong Lin

A Large-scale genetic association study of esophageal adenocarcinoma risk

scientific article

A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline

scientific article

A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes

scientific article

A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh

scientific article

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

A powerful and flexible multilocus association test for quantitative traits

scientific article published on February 2008

A tobit variance-component method for linkage analysis of censored trait data

scientific article

ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies

scientific article published on 01 March 2019

Accelerated DNA methylation age and the use of antihypertensive medication among older adults

scientific article published on 01 November 2018

Admixture mapping identifies novel loci for obstructive sleep apnea in hispanic/latino americans

scientific article published on 01 February 2019

Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts

scientific article published on 26 December 2019

Analytic P-value calculation for the higher criticism test in finite d problems

scientific article

Ancestry estimation and control of population stratification for sequence-based association studies

scientific article

Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer

journal article published in 2008

Application of linear mixed-effects model with LASSO to identify metal components associated with cardiac autonomic responses among welders: a repeated measures study

scientific article

Are the Associations of Cardiac Acceleration and Deceleration Capacities With Fine Metal Particulate in Welders Mediated by Inflammation?

scientific article

Arsenic reduction in drinking water and improvement in skin lesions: a follow-up study in Bangladesh

scientific article published on 10 October 2012

Ascertainment-adjusted parameter estimates revisited

scientific article published on 05 March 2002

Assessment of occupational exposure to manganese and other metals in welding fumes by portable X-ray fluorescence spectrometer

journal article published in 2010

Association Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors.

scientific article published on 12 September 2016

Association Between Tumor Progression Endpoints and Overall Survival in Patients with Advanced Neuroendocrine Tumors

scientific article published on 8 February 2017

Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis ⬇️

scientific article published on September 13, 2012

Association of Neutrophil to Lymphocyte Ratio With Pulmonary Function in a 30-Year Longitudinal Study of US Veterans

scientific article published on 01 July 2020

Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China

scientific article published on 10 April 2020

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

scientific article published on 16 April 2019

Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data

journal article published in 2008

Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood

scientific article

Building an International Consortium for Tracking Coronavirus Health Status

scientific article published on 06 April 2020

Building an international consortium for tracking coronavirus health status

scientific article published on 02 June 2020

COVID-19 Spread Mapper: a multi-resolution, unified framework and open-source tool

scientific article published in 2022

Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer

scientific article

Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database.

scientific article published on 22 March 2013

Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males

scientific article published on 01 December 2019

Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses

scientific article published on April 2016

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

scientific article published on 22 March 2016

Coronary artery calcification progression is heritable

scientific article published on 11 June 2007

Correction for population stratification in random forest analysis ⬇️

scientific article published on November 12, 2012

Correction for: Accelerated DNA methylation age and the use of antihypertensive medication among older adults

scientific article published on 01 May 2019

CpGFilter: model-based CpG probe filtering with replicates for epigenome-wide association studies.

scientific article published on 07 October 2015

Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes

scientific article

Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort

scientific article published on 15 August 2018

DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence

article

Design and analysis issues in gene and environment studies ⬇️

scientific article (publication date: 19 December 2012)

Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies ⬇️

scientific article published on November 26, 2012

Detection of Local DNA Copy Number Changes in Lung Cancer Population Analyses Using A Multi-Scale Approach

scientific article published on 01 January 2015

Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies

scientific article published on 12 April 2019

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

scientific article published on 24 August 2020

Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies

scientific article published on 10 January 2019

Empirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans.

scientific article published on 19 April 2017

Empower an End-to-end Scalable and Interpretable Data Science Ecosystem using Statistics, AI and Domain Science

scientific article published on 25 August 2024

Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva

scientific article published on 06 February 2019

Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC.

scientific article

Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study

scientific article

Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations

scientific article published on 01 August 2019

Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

scientific article published on 17 April 2018

Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization

scientific article published on 28 March 2019

Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers

scientific article published on 12 February 2020

Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria

scientific article published on 02 September 2020

Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease

scientific article published on 15 January 2016

Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study

scientific article published on 25 August 2017

Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway

scientific article published on April 2013

Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA

scientific article

GEE-based SNP set association test for continuous and discrete traits in family-based association studies

scientific article

Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study

scientific article published on December 2013

General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies ⬇️

scientific article published on June 13, 2013

Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans

scientific article

Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes ⬇️

scientific article published on August 14, 2013

Genetic Variant Set-Based Tests Using the Generalized Berk-Jones Statistic with Application to a Genome-Wide Association Study of Breast Cancer

scientific article published on 16 October 2019

Genetic Variants on 15q25.1, Smoking, and Lung Cancer: An Assessment of Mediation and Interaction ⬇️

scientific article published on February 3, 2012

Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study.

scientific article published in August 2016

Genetic associations with sporadic neuroendocrine tumor risk

journal article published in 2011

Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk

scientific article published on 09 September 2008

Genetic predictors of bronchial reactivity in adult Chinese females

abstract published in 2010

Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

scientific article published on 3 August 2011

Genome sequencing analysis identifies Epstein–Barr virus subtypes associated with high risk of nasopharyngeal carcinoma

scientific article published on 17 June 2019

Genome-wide Association Analysis for Multiple Continuous Secondary Phenotypes ⬇️

scientific article published on May 2, 2013

Genome-wide Gene-Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk

scientific article

Genome-wide analysis of survival in early-stage non-small-cell lung cancer

scientific article published on 04 May 2009

Genome-wide association and network analysis of lung function in the Framingham Heart Study

scientific article

Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

scientific article

Genome-wide methylation analysis identifies novel CpG loci for perimembranous ventricular septal defects in human

scientific article published on 31 January 2017

Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer

scientific article

Group testing via hypergraph factorization applied to COVID-19

scientific article published in 2022

Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women

scientific article

Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study

scientific article

Identification of differentially expressed gene sets using the Generalized Berk-Jones statistic

scientific article published on 01 November 2019

Identification of novel loci associated with infant cognitive ability

journal article published in 2020

Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test ⬇️

scientific article published on June 25, 2012

Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer.

scientific article

Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective

scientific article published on 28 February 2019

Improved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation

scientific article

Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer Survival.

scientific article published on 14 May 2014

Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival

scientific article

Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer

scientific article published on 14 September 2020

Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma

scientific article

Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study

scientific article

Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies

scientific article

Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders

scientific article

Matrix Gla Protein Gene Polymorphism Is Associated With Increased Coronary Artery Calcification Progression ⬇️

scientific article published on January 10, 2013

Mediation analysis for common binary outcomes

scientific article published on 06 September 2018

Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model

scientific article

Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts

scientific article published on 21 October 2018

Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival

scientific article

Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma.

scientific article published on 31 May 2018

Multi-ethnic Meta-analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea Related Quantitative Trait Locus in Men.

scientific article

Multiple phenotype association tests using summary statistics in genome-wide association studies.

scientific article

Multivariate Gene Selection and Testing in Studying the Exposure Effects on a Gene Set

scientific article

Neuropsychological effects of low-level manganese exposure in welders

journal article published in 2011

Nonsteroidal Antiinflammatory Drugs Modify the Effect of Short-Term Air Pollution on Lung Function

scientific article published on 01 February 2020

Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies

scientific article published on 28 December 2019

Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies ⬇️

scientific article published on August 2, 2012

Optimal tests for rare variant effects in sequencing association studies

scientific article

Parity and risk of lung cancer in women

scientific article

Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood

scientific article

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

article

Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development

scientific article

Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk

scientific article

Population-scale Longitudinal Mapping of COVID-19 Symptoms, Behavior, and Testing Identifies Contributors to Continued Disease Spread in the United States

scientific article published on 11 June 2020

Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing

scientific article published on 26 August 2020

Powerful SNP-set analysis for case-control genome-wide association studies

scientific article

Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic

article

Powerful tests for detecting a gene effect in the presence of possible gene-gene interactions using garrote kernel machines

scientific article

Prior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways

Prioritizing individual genetic variants after kernel machine testing using variable selection.

scientific article published on 3 August 2016

Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.

scientific article published on 26 August 2013

Progression of subclinical coronary atherosclerosis: does obesity make a difference?

scientific article

Publisher Correction: Building an international consortium for tracking coronavirus health status

scientific article published on 26 June 2020

Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments

scientific article

Rare variant association test in family-based sequencing studies

scientific article published on 26 September 2016

Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.

scientific article

Rare-variant association analysis: study designs and statistical tests

scientific article

Rare-variant association testing for sequencing data with the sequence kernel association test

scientific article

Reconstruction of the full transmission dynamics of COVID-19 in Wuhan

scientific article published on 16 July 2020

Reflections on the 1962 Paper "The Statistician in Medicine" by Sir Austin Bradford Hill

scientific article published on 01 January 2021

Robust analysis of secondary phenotypes in case-control genetic association studies

scientific article published on 30 May 2016

SNP Set Association Analysis for Familial Data ⬇️

scientific article published on September 11, 2012

Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level

scientific article published on 24 October 2019

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

scientific article published on 6 March 2019

Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study

scientific article

Short-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders: a repeated-measures panel study

journal article published in 2016

Some considerations of classification for high dimension low-sample size data

scientific article

Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection.

scientific article published on 25 January 2009

Sparse principal component analysis for identifying ancestry-informative markers in genome-wide association studies

scientific article published on 16 April 2012

Test for interactions between a genetic marker set and environment in generalized linear models ⬇️

scientific article published on 05 March 2013

Test for rare variants by environment interactions in sequencing association studies

scientific article published on 30 July 2015

Testing for gene-environment interaction under exposure misspecification.

scientific article

Testing for the indirect effect under the null for genome-wide mediation analyses.

scientific article published on 29 October 2017

The association between global DNA methylation and telomere length in a longitudinal study of boilermakers

journal article published in 2014

The effect of correlation in false discovery rate estimation

scientific article

The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study

scientific article

Toenail, Blood, and Urine as Biomarkers of Manganese Exposure ⬇️

scientific article published on May 1, 2011

Trans-ethnic genome-wide association study of severe COVID-19

scientific article

Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis

scientific article published in December 2023

Unraveling US National COVID-19 Racial/Ethnic Disparities using County Level Data Among 328 Million Americans

scientific article published on 04 December 2020

Using canonical correlation analysis to discover genetic regulatory variants

scientific article

Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma.

scientific article published on 31 May 2013

VARIABLE SELECTION FOR HIGH DIMENSIONAL MULTIVARIATE OUTCOMES.

scientific article published on October 2014

VEGF polymorphisms and survival in early-stage non-small-cell lung cancer

scientific article published in February 2008

Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level

scientific article

Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome

scientific article

Weighted pseudolikelihood for SNP set analysis with multiple secondary outcomes in case-control genetic association studies

scientific article published on 27 March 2017

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

scientific article

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