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List of works by Xavier Saelens

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

scientific article published in May 2003

A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody

scientific article published on 27 March 2015

A Respiratory Syncytial Virus vaccine based on the Small Hydrophobic protein ectodomain presented with a novel lipid-based formulation is highly immunogenic and safe in adults: a first-in-humans study

scientific article published on 30 March 2018

A fairly conserved epitope on the hemagglutinin of influenza A (H3N2) virus with variable accessibility to neutralizing antibody

scientific article

A novel caspase-2 complex containing TRAF2 and RIP1.

scientific article

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus ⬇️

scientific article published on April 8, 2011

A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine

scientific article

A two-amino acid mutation in murine IgA enables downstream processing and purification on staphylococcal superantigen-like protein 7

scientific article published on 13 February 2019

A universal influenza A vaccine based on the extracellular domain of the M2 protein

scientific article

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

scientific article

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

scientific article published on 27 January 2016

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

scientific article

Alice in caspase land. A phylogenetic analysis of caspases from worm to man

scientific article published on 01 April 2002

An Inside Job: Applications of Intracellular Single Domain Antibodies

scientific article published on 12 December 2020

An influenza A vaccine based on tetrameric ectodomain of matrix protein 2.

scientific article published on 5 February 2008

Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing

scientific article published on 14 February 2015

Antibodies directed towards neuraminidase N1 control disease in a mouse model of influenza

scientific article published on 22 November 2017

Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells

scientific article published on 31 January 2022

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

scientific article published on 25 July 2013

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective ⬇️

scientific article published on October 21, 2010

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.

scientific article published on February 2005

Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro

scientific article (publication date: 2011)

Author Correction: A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine

scientific article published in Scientific Reports

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

scientific article published on January 2004

Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection

scientific article published on 28 February 2017

Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs

Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration

scientific article published on 4 May 2017

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

scientific article published in January 2006

CD8+ T cell immunity against human respiratory syncytial virus

scientific article published on 16 September 2014

CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

scientific article

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

scientific article published on 23 March 2004

Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis.

scientific article published on May 2003

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis

scientific article published on January 2007

Caspases are not localized in mitochondria during life or death

scientific article published in November 2002

Cell-Mediated Responses to Human Metapneumovirus Infection

scientific article published on 14 May 2020

Challenges and advances towards the rational design of mRNA vaccines

scientific article published on 15 October 2013

Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.

scientific article published on 23 December 2016

Clinical Potential of Prefusion RSV F-specific Antibodies.

scientific article

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

scientific article published on 21 April 2015

Controlling influenza by cytotoxic T-cells: calling for help from destroyers

scientific article

Correction: A20 () Deficiency in Myeloid Cells Protects against Influenza A Virus Infection

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

scientific article published on 29 November 2017

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody

scientific article

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells ⬇️

scientific article published on 30 August 2019

Developing 3D SEM in a broad biological context

scientific article published on 26 January 2015

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

scientific article published on 10 December 2003

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

scientific article

Effect of serial pig passages on the adaptation of an avian H9N2 influenza virus to swine.

scientific article

Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.

scientific article published on January 1998

Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein

scientific article published on 12 June 2020

Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies

scientific article published on 22 October 2019

Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses

scientific article published on 19 August 2015

GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

scientific article

Hepatitis B core–based virus–like particles to present heterologous epitopes ⬇️

scientific article published on February 1, 2013

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies

scientific article published on 11 January 2017

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation

scientific article

Identification of peptide domains involved in the subcellular localization of the feline coronavirus 3b protein

scientific article published on 30 August 2019

Identification of polymorphisms in the ovine Shadow of prion protein (SPRN) gene and assessment of their effect on promoter activity and susceptibility for classical scrapie

scientific article published on 16 November 2009

IgG3 Snitcher of RSV Infections in the Very Young

scientific article published on 30 January 2017

Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene.

scientific article

Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge

scientific article published on 24 September 2012

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

scientific article

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e.

scientific article

Improved design and intranasal delivery of an M2e-based human influenza A vaccine

scientific article published on 12 June 2006

In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides--evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei

scientific article

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice

scientific article

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12.

scientific article

Influenza vaccines to control influenza-associated bacterial infection: where do we stand?

scientific article

Influenza vaccines: T-cell responses deserve more attention

scientific article published on August 1, 2012

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

scientific article published on 29 January 2016

Insight into Highly Conserved H1 Subtype-Specific Epitopes in Influenza Virus Hemagglutinin

scientific article

Insight into structural diversity of influenza virus haemagglutinin ⬇️

scientific article published on May 1, 2013

Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly ⬇️

scientific article published on September 26, 2012

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

scientific article published on 25 July 2019

Influenza and Memory T Cells: How to Awake the Force

scientific article

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules

scientific article (publication date: April 2011)

Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies

scientific article

M2-based influenza vaccines: recent advances and clinical potential

scientific article published on 22 September 2016

M2e-Based Universal Influenza A Vaccines

scientific article

M2e-based universal influenza A vaccine

scientific article

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A.

scientific article

M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection.

scientific article published on 15 March 2017

Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system's productivity

scientific article published on 20 November 2013

Mitochondrial intermembrane proteins in cell death

scientific article

Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells

scientific article

Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited

scientific article published in March 2014

Mx proteins: antiviral gatekeepers that restrain the uninvited

scientific article published on December 2013

Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection

scientific article published on 17 July 2019

Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection

scientific article

Nanobodies® Specific for Respiratory Syncytial Virus Fusion Protein Protect Against Infection by Inhibition of Fusion ⬇️

scientific article published on October 12, 2011

Nanobodies®: New ammunition to battle viruses ⬇️

scientific article published on September 10, 2011

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

scientific article

Necrosis is associated with IL-6 production but apoptosis is not.

scientific article published on 14 July 2005

Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein

scientific article published in Scientific Reports

New antibody-based prevention and treatment options for influenza

scientific article published on 16 July 2019

Next-Generation Sequencing: An Eye-Opener for the Surveillance of Antiviral Resistance in Influenza

scientific article published on 04 December 2019

Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection

scientific article

One Against All: A Broadly Influenza Neutralizing Man-made Monoclonal Antibody Passes Phase I.

scientific article

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

scientific article published on 17 December 2015

Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus

scientific article

P131 STAT transcriptional activity is controlled by regulated deacetylation

Pandemic preparedness: toward a universal influenza vaccine

scientific article

Passively transferred M2e-specific monoclonal antibody reduces influenza A virus transmission in mice

scientific article published on 01 September 2018

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

scientific article published on 10 December 2003

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages

scientific article published on 2 August 2016

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

scientific article published on 13 February 2012

Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist.

scientific article

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

scientific article published on 13 February 2017

Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes

scientific article

Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages

scientific article published on 14 May 2015

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein

scientific article

Protection of Mice Against a Lethal Influenza Challenge by Immunization with Yeast‐Derived Recombinant Influenza Neuraminidase ⬇️

scientific article published on July 1, 1997

Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin

scientific article published in February 1999

Protein synthesis persists during necrotic cell death

scientific article published on 7 February 2005

Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases

scientific article published on 10 April 2003

Proteome-wide Identification of HtrA2/Omi Substrates

scientific article

Recombinant Influenza Virus Carrying the Respiratory Syncytial Virus (RSV) F 85-93 CTL Epitope Reduces RSV Replication in Mice ⬇️

scientific article published on January 9, 2013

Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice

scientific article published on 20 August 2020

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

scientific article published on 29 March 2022

Regulation of kynurenine biosynthesis during influenza virus infection.

scientific article published on 18 November 2016

Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization

article

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses

scientific article published on 17 October 2019

Reverse engineering synthetic antiviral amyloids

scientific article published on 05 June 2020

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

scientific article published on 01 October 2021

Role of IFN-alpha during the acute stage of a swine influenza virus infection

scientific article published on 31 July 2009

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

scientific article published on 17 November 2020

Scop3D: three-dimensional visualization of sequence conservation

scientific article published on 3 March 2015

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection

scientific article published on 12 December 2019

Sequence-dependent internalization of aggregating peptides

scientific article

Single-Domain Antibodies and Their Formatting to Combat Viral Infections

scientific article published on 20 December 2018

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge

scientific article published on 14 May 2014

Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen

scientific article

Soluble recombinant influenza vaccines ⬇️

scientific article published on December 29, 2001

Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ

scientific article published on 18 October 2018

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

scientific article published on 23 July 2020

Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine

scientific article published on 27 December 2008

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

scientific article published on 29 April 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

scientific article published on 01 June 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

scientific article (preprint)

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody

scientific article published on 21 January 2015

Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface

scientific article published on 14 March 2019

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

scholarly article by Pieterjan Merckx published in September 2018

TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection

scientific article published on 12 September 2019

Tailor-made cleavage site attenuates influenza B ⬇️

scientific article published on February 1, 2012

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

scientific article published on May 2015

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

scientific article published on 11 September 2020

The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines

article

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

scientific article

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation

scientific article published on 23 February 2007

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

scientific article

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections ⬇️

scientific article published on September 1, 2011

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

scientific article

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection

scientific article

Therapeutic anti-tumor immunity directed against neo-epitopes by intratumor delivery of mRNA encoding MLKL

scientific article published on 02 October 2018

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

scientific article published in September 2002

Toxic proteins released from mitochondria in cell death

scientific article published on April 2004

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant.

scientific article published on 26 November 2017

Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

scientific article (publication date: 9 November 2001)

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

scientific article published in Nature Communications

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

scientific article published on 10 August 2016

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments.

scientific article

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

scientific article published in December 2008

Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.

scientific article published on 17 December 2010

Use of HDEL-tagged Trichoderma reesei mannosyl oligosaccharide 1,2-alpha-D-mannosidase for N-glycan engineering in Pichia pastoris

scientific article published in August 2001

Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses

scientific article published on 05 February 2019

Vaccine options for influenza: thinking small.

scientific article

Vaccines against human respiratory syncytial virus in clinical trials, where are we now?

scientific article published on 14 October 2019

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