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List of works by Jacob Nielsen

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

scientific article published on 22 March 2021

A double-blind, randomized, placebo-controlled proof of concept study of the efficacy and safety of Lu AF11167 for persistent negative symptoms in people with schizophrenia

scientific article published in 2022

Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity

scientific article

Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

scientific article published on 12 July 2018

Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

scientific article

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

scientific article published on 17 June 2019

Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization

scientific article (publication date: 2011)

Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain.

scientific article published on 3 July 2014

Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.

scientific article

Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor.

scientific article published on 12 April 2007

Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.

scientific article

Molecular cloning and pharmacological characterization of serotonin 5-HT(3A) receptor subtype in dog.

scientific article published on 27 March 2006

OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome

scientific article published in February 2018

PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia ⬇️

scientific article published on January 1, 2011

PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

scientific article published on 14 September 2017

Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum

scientific article published on 16 March 2019

Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors ⬇️

scientific article published on November 17, 2010

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices.

scientific article published on 21 December 2017

The translationally relevant mouse model of the 15q13.3 microdeletion syndrome reveals deficits in neuronal spike firing matching clinical neurophysiological biomarkers seen in schizophrenia.

scientific article

Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations

scientific article published on 08 November 2019

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors ⬇️

scientific article published on April 30, 2011

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