List of works - Wolfram Bode

(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode

scientific article

1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase

scientific article published in July 2004

157 The “activation domain”: A highly cooperative entity within the catalytic domain of serine proteinases

A standard orientation for metallopeptidases

scientific article published on 30 April 2011

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

scientific article

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

scientific article published in February 2002

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

scientific article

Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.

scientific article

Conformational Variability of Chicken Cystatin

article

Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity

scientific article published in April 2004

Crystal structure of the apoptosis-inducing human granzyme A dimer

scientific article

Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides

scientific article

Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain

scientific article

Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity

scientific article

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

scientific article

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

scientific article

Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain

scientific article (publication date: 2000)

Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors

scientific article (publication date: 18 April 2003)

Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid)

scientific article

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes

scientific article

Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain

scientific article published in September 2002

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

scientific article published on 5 December 2002

Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine

scientific article published on 14 June 2004

Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).

scientific article published in February 2006

Macrocyclic statine-based inhibitors of BACE-1.

scientific article published on November 2007

Mutations of the PC2 substrate binding pocket alter enzyme specificity

scientific article published on 7 July 2005

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions

scientific article

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

scientific article

Pore-forming scissors? A first structural glimpse of gamma-secretase.

scientific article published on 4 August 2006

Properties of purified gut trypsin from Helicoverpa zea, adapted to proteinase inhibitors

scientific article published on January 2003

Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

scientific article published in January 2005

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

scientific article

Specific inhibition of insect alpha-amylases: yellow meal worm alpha-amylase in complex with the amaranth alpha-amylase inhibitor at 2.0 A resolution

scientific article

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

scientific article (publication date: September 2006)

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

scientific article

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation

scientific article published on 17 October 2005

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

scientific article

Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membrane

scientific article

Structural basis of matrix metalloproteinase function ⬇️

scientific article published on January 1, 2003

Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases

scientific article (publication date: November 2003)

Structural basis of the activation and action of trypsin

article

Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases

scientific article

Structural basis of the zinc inhibition of human tissue kallikrein 5

scientific article

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

scientific article published on 16 July 2018

Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex

scientific article

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

article

Structure and interaction modes of thrombin

scientific article

Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue

scientific article published on 9 September 2007

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

scientific article published on June 2008

The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase

scientific article

The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link

scientific article

The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features

scientific article

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS

scientific article

The NC1 dimer of human placental basement membrane collagen IV: does a covalent crosslink exist?

scientific article

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

scientific article (publication date: 29 April 2003)

The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region

scientific article

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

scientific article

The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.

scientific article published in January 2004

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved

scientific article published in October 2002

The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage

scientific article

The structure of thrombin: a janus-headed proteinase

scientific article

Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops

scientific article

Thrombin inhibitors identified by computer-assisted multiparameter design

scientific article

X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding

scientific article published on 15 December 2004

X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases

scientific article

X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition

scientific article published on 28 December 2005

List of works by Wolfram Bode

(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode

1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase

157 The “activation domain”: A highly cooperative entity within the catalytic domain of serine proteinases

A standard orientation for metallopeptidases

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.

Conformational Variability of Chicken Cystatin

Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity

Crystal structure of the apoptosis-inducing human granzyme A dimer

Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides

Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain

Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain

Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors

Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid)

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes

Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine

Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).

Macrocyclic statine-based inhibitors of BACE-1.

Mutations of the PC2 substrate binding pocket alter enzyme specificity

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

Pore-forming scissors? A first structural glimpse of gamma-secretase.

Properties of purified gut trypsin from Helicoverpa zea, adapted to proteinase inhibitors

Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

Specific inhibition of insect alpha-amylases: yellow meal worm alpha-amylase in complex with the amaranth alpha-amylase inhibitor at 2.0 A resolution

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membrane

Structural basis of matrix metalloproteinase function ⬇️

Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases

Structural basis of the activation and action of trypsin

Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases

Structural basis of the zinc inhibition of human tissue kallikrein 5

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

Structure and interaction modes of thrombin

Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase

The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link

The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS

The NC1 dimer of human placental basement membrane collagen IV: does a covalent crosslink exist?

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved

The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage

The structure of thrombin: a janus-headed proteinase

Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops

Thrombin inhibitors identified by computer-assisted multiparameter design

X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding

X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases

X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition