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List of works by Takeharu Sakamoto

A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism

scientific article

Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.

scientific article

Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system.

scientific article published on 28 July 2017

Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.

scientific article published on 21 July 2011

Electron microscopic observation of photoreceptor cells in directly inserted anesthetized Drosophila into a high-pressure freezing unit

scientific article published on 23 December 2018

Genetic Screening of New Genes Responsible for Cellular Adaptation to Hypoxia Using a Genome-Wide shRNA Library ⬇️

scientific article published on April 16, 2012

Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion ⬇️

scientific article published on August 27, 2011

Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.

scientific article published on 28 October 2013

Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.

scientific article published on 10 August 2009

Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase

scientific article published on 7 March 2017

Investigation of a MMP-2 activity-dependent anchoring probe for nuclear imaging of cancer

scientific article (publication date: 2014)

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

scientific article published on 27 April 2012

Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1

scientific article published on 21 August 2020

Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice.

scientific article

Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses

scientific article published on 03 October 2016

Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth.

scientific article published on 15 May 2017

Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus

scientific article

NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.

scientific article

Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.

scientific article published on 29 January 2018

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

scientific article published on 07 October 2021

Scaffold protein Lin7 family in membrane skeletal protein complex in mouse seminiferous tubules

scientific article published on 13 August 2019

Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.

scientific article published on May 2007

Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase

scientific article

The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux.

scientific article published on 26 July 2016

The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system

article

ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.

scientific article published on January 2011

ZF21 protein regulates cell adhesion and motility.

scientific article

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