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List of works by Jae H Chang

Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4.

scientific article

Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message.

scientific article

CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339.

scientific article published on 08 August 2017

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

scientific article

Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic Acid

scientific article published on 26 September 2019

Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.

scientific article published on 26 March 2014

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

scientific article

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

scientific article

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

scientific article published on 19 January 2016

Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927

scientific article published on 06 July 2019

Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.

scientific article published on 21 June 2013

Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.

scientific article published on September 2005

Insensitivity to pain upon adult-onset deletion of Na1.7 or its blockade with selective inhibitors

scientific article published on 09 October 2018

Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats

scientific article published on 06 September 2019

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

scientific article published on 20 February 2019

Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System

scientific article published on 12 July 2015

Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model

scientific article published on 18 August 2016

Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.

scientific article

Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers

scientific article published on 01 September 2019

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

scientific article published on 16 April 2019

The role of P-glycoprotein in the bioactivation of raloxifene

scientific article published on 07 September 2006

The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe.

scientific article

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study

scientific article published on 01 January 2019

Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse

scientific article published on 06 June 2018

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