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List of works by Takao Iwawaki

2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms

scientific article published on 27 August 2015

A transgenic mouse model for monitoring oxidative stress.

scientific article published on 19 January 2012

Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis.

scientific article

C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation

scientific article published on 17 February 2011

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

scientific article published on 9 May 2013

Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway.

scientific article published on 20 August 2013

Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells

scientific article published on 28 August 2015

Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury.

scientific article published on 7 October 2014

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

scientific article published on 12 January 2017

Deletion of inositol-requiring enzyme-1α in podocytes disrupts glomerular capillary integrity and autophagy

scientific article published on 20 April 2017

Detection of ER stress in vivo by Raman spectroscopy

scientific article published on 30 December 2010

Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice.

scientific article published on 10 December 2007

ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

scientific article published on 16 September 2013

Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells.

scientific article published on 19 June 2017

Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.

scientific article published on 12 December 2012

Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice.

scientific article published in July 2014

Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing

scientific article published on September 6, 2011

IRE1 signaling exacerbates Alzheimer's disease pathogenesis

scientific article published on 24 March 2017

IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.

scientific article published on 5 March 2018

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level ⬇️

scientific article published on September 27, 2010

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

scientific article published on 30 January 2012

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

scientific article published on 16 July 2018

IRE1α promotes viral infection by conferring resistance to apoptosis.

scientific article published on 6 June 2017

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival

scientific article published on 10 June 2020

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

scientific article

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

scientific article

Identification of a consensus element recognized and cleaved by IRE1 alpha.

scientific article published on 27 May 2010

Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue

scientific article published on 18 September 2013

Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST

scientific article published on 26 March 2013

Modulation of Unfolded Protein Response by Methylmercury

scientific article published in January 2017

Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles

scientific article published on 10 October 2017

Paneth cells as a site of origin for intestinal inflammation.

scientific article

Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice.

scientific article published on 29 September 2009

Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland

scientific article published on 30 September 2009

Positive contribution of IRE1α–XBP1 pathway to the expression of placental cathepsins ⬇️

scientific article published on March 26, 2013

Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.

scientific article

Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.

scientific article

Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress.

scientific article

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.

scientific article published on 22 November 2017

Regulation of human STARD4 gene expression under endoplasmic reticulum stress.

scientific article

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress

scientific article published on 8 October 2015

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

scientific article

Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1

scientific article

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

scientific article published in Nature Communications

Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury

scientific article published on 15 April 2014

The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

scientific article published on 18 March 2011

The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control

scientific article

The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.

scientific article published on 22 July 2010

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.

scientific article published on 19 January 2014

Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo

scientific article

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