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List of works by Joaquin Arribas

A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers.

scientific article

ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin ⬇️

scientific article published on December 20, 2010

ADAM17 as a therapeutic target in multiple diseases.

scientific article published on January 2009

Cancer Therapeutic Resistance: Progress and Perspectives (April 7-8, 2016 - Barcelona, Spain).

scientific article

Cancer network activity associated with therapeutic response and synergism

scientific article published on 24 August 2016

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

scientific article published on 18 June 2019

Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.

scientific article published on 20 April 2010

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

scientific article

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

scientific article published on 20 August 2018

Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy.

scientific article published on 23 February 2018

Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting.

scientific article

Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence.

scientific article

Defective cyclin B1 induction in trastuzumab-emtansine (T-DM1) acquired resistance in HER2-positive breast cancer.

scientific article published on 18 August 2017

Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17.

scientific article published on November 2005

Effect of cellular senescence on the growth of HER2-positive breast cancers.

scientific article published on 13 May 2015

Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

scientific article

Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study

scientific article published on 28 December 2018

Enhancing the Biological Relevance of Secretome-Based Proteomics by Linking Tumor Cell Proliferation and Protein Secretion

scientific article published on 15 July 2014

Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

scientific article published on April 2007

Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer

scientific article published on 22 August 2018

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells

scientific article published on 23 May 2022

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer

scientific article published on 22 July 2016

Genetic alterations in the PI3K/AKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts

scientific article published on 27 March 2020

HER2 Fragmentation and Breast Cancer Stratification ⬇️

scientific article published on 03 August 2010

HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

scientific article published on 04 March 2019

High HER2 expression correlates with response to the combination of lapatinib and trastuzumab.

scientific article published on 2 December 2014

High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy.

scientific article published on 15 September 2015

Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.

scientific article published in April 2015

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells

scientific article published on 28 August 2019

MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors

scientific article published on 21 June 2019

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

scientific article

Matrix metalloproteases and tumor invasion

scientific article published on 01 May 2005

Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts.

scientific article published on September 2016

Modulation of the Multicatalytic Proteinase Complex by Lipids, Interconversion and Proteolytic Processing ⬇️

scientific article published on 01 January 1993

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

scientific article published on 21 September 2018

N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity.

scientific article published on July 2005

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

scientific article

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis.

scientific article published on 3 October 2017

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

scientific article published on 01 July 2018

Pancreatic cancer heterogeneity and response to Mek inhibition

scientific article published on 5 June 2017

Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies

scientific article published on 15 June 2015

Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.

scientific article published on 12 August 2014

Preclinical activity of PI3K inhibitor Copanlisib in Gastrointestinal Stromal Tumor

scientific article published on 05 May 2020

Pro-Tumor Necrosis Factor-α Processing Activity Is Tightly Controlled by a Component That Does Not Affect Notch Processing ⬇️

scientific article published on September 18, 1998

Publisher Correction: MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer.

scientific article

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.

scientific article published on 4 April 2018

Recycling of cell surface pro-transforming growth factor-{alpha} regulates epidermal growth factor receptor activation.

scientific article published on 29 August 2005

Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity

scientific article published on 7 July 2017

Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.

scientific article

Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth.

scientific article

TGFβ-activated USP27X deubiquitinase regulates cell migration and chemoresistance via stabilization of Snail1

scientific article published on 19 October 2018

TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells

scientific article published on 27 March 2019

Targeting the EGF/HER Ligand-Receptor System in Cancer.

scientific article

The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration

scientific article

The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells

scientific article published on 02 August 2012

Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer

scientific article published on 07 February 2019

Treating cancer's kinase 'addiction'.

scientific article published in August 2004

Who will benefit from treatment against EGFR?

scientific article published on 01 May 2005

p95HER2 and Breast Cancer ⬇️

scientific article published on February 22, 2011

p95HER2-T cell bispecific antibody for breast cancer treatment

scientific article published on 01 October 2018

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