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List of works by Kenta Haraya

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A.

scientific article published on October 2014

Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation

scientific article published in February 2014

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

scientific article published in PLoS ONE

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.

scientific article

Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.

scientific article published on 17 July 2014

Effect of streptozotocin-induced diabetes mellitus on the pharmacokinetics of nelfinavir in rats.

scientific article published in November 2008

Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131

scientific article

Engineered monoclonal antibody with novel antigen-sweeping activity in vivo.

scientific article

Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity

scientific article

Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

scientific article published on 7 April 2017

Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering

scientific article published on 01 November 2018

Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering.

scientific article published on 28 August 2015

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

scientific article published on 24 April 2017

Long-term pharmacokinetic efficacy and safety of low-dose ritonavir as a booster and atazanavir pharmaceutical formulation based on solid dispersion system in rats.

scientific article published in June 2008

PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody-antigen binding model.

scientific article published on 6 January 2016

Pharmaceutical approach to HIV protease inhibitor atazanavir for bioavailability enhancement based on solid dispersion system

scientific article published on 01 April 2007

Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey

scientific article

Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers.

scientific article published on 24 March 2016

Prediction of inter-individual variability on the pharmacokinetics of CYP2C8 substrates in human

scientific article published on 15 September 2017

Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human.

scientific article

Simple Approach to Accurately Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies after Subcutaneous Injection in Humans

scientific article published on 11 August 2020

Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.

scientific article published on March 2016

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