List of works - Willem A. Van Otterlo

1-Benzyl-3,3-dichloro-1H-indol-2(3H)-one.

scientific article published on 10 February 2007

2-{[(4-Methylphenyl)sulfonyl]amino}phenyl 4-methylbenzenesulfonate

scientific article published on 28 April 2007

Alkaloids with Activity against the Zika Virus Vector Aedes aegypti (L.)—Crinsarnine and Sarniensinol, Two New Crinine and Mesembrine Type Alkaloids Isolated from the South African Plant Nerine sarniensis

scientific article (publication date: 27 October 2016)

Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

scientific article

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

scientific article published on 17 January 2019

Bidirectional racemic synthesis of the biologically active quinone cardinalin 3

scientific article published on 26 June 2007

Bioactivity-guided mapping and navigation of chemical space.

scientific article

Bulbispermine: A Crinine‐Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity toward Apoptosis‐Resistant Glioma Cells ⬇️

scientific article published on March 2, 2012

C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.

scientific article published on 24 December 2013

Composites of polyvinyl alcohol and carbon (coils, undoped and nitrogen doped multiwalled carbon nanotubes) as ethanol, methanol and toluene vapor sensors

scientific article published on 01 November 2011

Correction to CAN-Mediated Oxidations for the Synthesis of Xanthones and Related Products

scientific article published on 13 December 2018

Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite

scientific article published on 05 October 2020

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

scientific article published on 14 January 2018

Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase

scientific article

Have lichenized fungi delivered promising anticancer small molecules?

In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives

scientific article

In search of a treatment for HIV--current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs).

scientific article published on 22 May 2012

Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs.

scientific article

Metathesis in the synthesis of aromatic compounds.

scientific article published on August 2009

Metathesis reactions for the synthesis of ring-fused carbazoles.

scientific article published in December 2005

Nanocomposites of gold and poly(3-hexylthiophene) containing fullerene moieties: Synthesis, characterization and application in solar cells

Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.

scientific article

Novel indole based NNRTIs with improved potency against wild type and resistant HIV.

scientific article

Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores.

scientific article published on 24 May 2013

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

scientific article published on 17 October 2019

Sarniensine, a mesembrine-type alkaloid isolated from Nerine sarniensis, an indigenous South African Amaryllidaceae, with larvicidal and adulticidal activities against Aedes aegypti

scientific article published on 15 November 2016

Stealth lipoplex decorated with triazole-tethered galactosyl moieties: a strong hepatotropic gene vector.

scientific article

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

scientific article

Synthesis and characterization of single wall carbon nanotube-grafted poly(3-hexylthiophene) and their nanocomposites with gold nanoparticles

Synthesis of novel triazole-linked mefloquine derivatives: biological evaluation against Plasmodium falciparum

scientific article published on 13 October 2014

Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.

scientific article

Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins

scientific article (publication date: July 2014)

The Phylum Bryozoa: From Biology to Biomedical Potential

scientific article published on 09 April 2020

The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.

scientific article published on 22 July 2009

The synthesis of angularly fused polyaromatic compounds by using a light-assisted, base-mediated cyclization reaction.

scientific article published on 4 November 2004

List of works by Willem A. Van Otterlo

1-Benzyl-3,3-dichloro-1H-indol-2(3H)-one.

2-{[(4-Methylphenyl)sulfonyl]amino}phenyl 4-methylbenzenesulfonate

Alkaloids with Activity against the Zika Virus Vector Aedes aegypti (L.)—Crinsarnine and Sarniensinol, Two New Crinine and Mesembrine Type Alkaloids Isolated from the South African Plant Nerine sarniensis

Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Bidirectional racemic synthesis of the biologically active quinone cardinalin 3

Bioactivity-guided mapping and navigation of chemical space.

Bulbispermine: A Crinine‐Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity toward Apoptosis‐Resistant Glioma Cells ⬇️

C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.

Composites of polyvinyl alcohol and carbon (coils, undoped and nitrogen doped multiwalled carbon nanotubes) as ethanol, methanol and toluene vapor sensors

Correction to CAN-Mediated Oxidations for the Synthesis of Xanthones and Related Products

Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase

Have lichenized fungi delivered promising anticancer small molecules?

In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives

In search of a treatment for HIV--current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs.

Metathesis in the synthesis of aromatic compounds.

Metathesis reactions for the synthesis of ring-fused carbazoles.

Nanocomposites of gold and poly(3-hexylthiophene) containing fullerene moieties: Synthesis, characterization and application in solar cells

Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.

Novel indole based NNRTIs with improved potency against wild type and resistant HIV.

Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores.

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

Sarniensine, a mesembrine-type alkaloid isolated from Nerine sarniensis, an indigenous South African Amaryllidaceae, with larvicidal and adulticidal activities against Aedes aegypti

Stealth lipoplex decorated with triazole-tethered galactosyl moieties: a strong hepatotropic gene vector.

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Synthesis and characterization of single wall carbon nanotube-grafted poly(3-hexylthiophene) and their nanocomposites with gold nanoparticles

Synthesis of novel triazole-linked mefloquine derivatives: biological evaluation against Plasmodium falciparum

Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.

Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins

The Phylum Bryozoa: From Biology to Biomedical Potential

The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.

The synthesis of angularly fused polyaromatic compounds by using a light-assisted, base-mediated cyclization reaction.