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List of works by Micheal J Zuscik

4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury

scientific article

5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.

scientific article published in May 2004

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

scientific article

A humoral immune defect distinguishes the response to Staphylococcus aureus infections in mice with obesity and type 2 diabetes from that in mice with type 1 diabetes

scientific article published on 23 March 2015

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

scientific article

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

scientific article published on January 2009

Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence

scientific article published on 20 March 2017

Aryl hydrocarbon receptor‐mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(α)pyrene ⬇️

scientific article published on March 1, 2012

Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis

scientific article published on 05 January 2019

Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.

scientific article

CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

scientific article published on 12 September 2015

COX-2 has a critical role during incorporation of structural bone allografts

scientific article published on 01 April 2006

Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice

scientific article published on 12 June 2019

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

scientific article published on 15 June 2017

Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis.

scientific article

Decreased BMP2 signal in GIT1 knockout mice slows bone healing.

scientific article published on 20 August 2014

Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus

scientific article

Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.

scientific article

Engineering superficial zone features in tissue engineered cartilage.

scientific article published on 27 December 2012

Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury.

scientific article published on 7 November 2016

Establishment of an index with increased sensitivity for assessing murine arthritis.

scientific article

Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering.

scientific article

Exacerbated Staphylococcus aureus Foot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity

scientific article published on 01 June 2018

Extraction of high-quality RNA from human articular cartilage.

scientific article

Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles.

scientific article published on 14 February 2005

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass

scientific article

Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling

scientific article published on 19 October 2012

High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury ⬇️

scientific article published on December 7, 2011

High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment

scientific article

Identification of a Conserved Switch Residue Responsible for Selective Constitutive Activation of the β2-Adrenergic Receptor ⬇️

scientific article published on February 6, 1998

Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur

scientific article published on 14 August 2013

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice

scientific article

Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

scientific article published on December 2005

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

scientific article published on October 2008

Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing

scientific article

Lead induces an osteoarthritis‐like phenotype in articular chondrocytes through disruption of TGF‐β signaling ⬇️

scientific article published on April 19, 2012

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

scientific article

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance

scientific article published on 30 October 2015

Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation and osteolysis during Staphylococcus aureus implant-associated bone infection

scientific article published on 11 December 2017

PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.

scientific article published in October 2004

Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.

scientific article published in September 2004

Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy

scientific article published on 01 March 2019

Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.

scientific article published in May 2004

RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.

scientific article

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

scientific article published on February 2009

Regulation of chondrogenesis and chondrocyte differentiation by stress.

scientific article published on February 2008

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.

scientific article published on 28 January 2008

Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.

scientific article published on August 2007

Shoulder arthritis secondary to rotator cuff tear: A reproducible murine model and histopathologic scoring system

scientific article published on 8 August 2016

Smad1 plays an essential role in bone development and postnatal bone formation ⬇️

scientific article published on March 21, 2011

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

scientific article

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

scientific article published on 27 May 2009

Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

scientific article published on 29 December 2015

Surgical induction of posttraumatic osteoarthritis in the mouse

scientific article published on 01 January 2014

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

scientific article published on 21 October 2013

Targeting the gut microbiome to treat the osteoarthritis of obesity.

scientific article published on 19 April 2018

Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes

scientific article

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

scientific article published on September 2011

Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects

scientific article

The gut microbiome-joint connection: implications in osteoarthritis

scientific article published on 01 January 2020

Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis.

scientific article

Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta

scientific article published on August 2005

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