List of works - Jean-François Guichou

A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

scientific article published on 18 June 2019

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study

scientific article published on 20 January 2016

Characterization of the anti-hepatitis C virus activity of new non-peptidic small-molecule cyclophilin inhibitors with a potential for broad anti-Flaviviridae activity.

scientific article

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography

scientific article

Crosslinking photosensitized by a ruthenium chelate as a tool for labeling and topographical studies of G-protein-coupled receptors.

scientific article published in January 2005

Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.

scientific article

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

scientific article

Fragment and conquer: from structure to complexes to function

scientific article published on 01 October 2012

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

scientific article

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity

scientific article

In-plate protein crystallization, in situ ligand soaking and X-ray diffraction

scientific article

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

scientific article

New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors.

scientific article

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.

scientific article published on April 2016

Novel and Selective TLR7 Antagonists among the Imidazo[1,2-a]pyrazines, Imidazo[1,5-a]quinoxalines, and Pyrazolo[1,5-a]quinoxalines Series

scientific article published on 19 July 2019

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

scientific article published on 13 April 2016

Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.

scientific article published on 11 June 2008

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations

scientific article

Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury

scientific article published on 20 July 2019

Strength and character of peptide/anion interactions.

scientific article

Structural basis for chemically-induced homodimerization of a single domain antibody

scientific article published in Scientific Reports

Structural basis for the interaction between focal adhesion kinase and CD4

scientific article

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

scientific article published in Scientific Reports

Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement

scientific article published on 06 July 2007

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity.

scientific article published on 31 January 2018

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

scientific article published on 28 March 2004

The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation

scientific article

The ellagitannin metabolite urolithin C is a glucose-dependent regulator of insulin secretion through activation of L-type calcium channels

scientific article published on 10 October 2019

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

scientific article published on 8 May 2018

Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution

scientific article

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA.

scientific article published on 30 October 2013

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design.

scientific article published on 26 April 2012

List of works by Jean-François Guichou

A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study

Characterization of the anti-hepatitis C virus activity of new non-peptidic small-molecule cyclophilin inhibitors with a potential for broad anti-Flaviviridae activity.

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography

Crosslinking photosensitized by a ruthenium chelate as a tool for labeling and topographical studies of G-protein-coupled receptors.

Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

Fragment and conquer: from structure to complexes to function

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity

In-plate protein crystallization, in situ ligand soaking and X-ray diffraction

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors.

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.

Novel and Selective TLR7 Antagonists among the Imidazo[1,2-a]pyrazines, Imidazo[1,5-a]quinoxalines, and Pyrazolo[1,5-a]quinoxalines Series

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.

Proceedings of the Frontiers of Retrovirology Conference 2016.

Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations

Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury

Strength and character of peptide/anion interactions.

Structural basis for chemically-induced homodimerization of a single domain antibody

Structural basis for the interaction between focal adhesion kinase and CD4

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity.

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation

The ellagitannin metabolite urolithin C is a glucose-dependent regulator of insulin secretion through activation of L-type calcium channels

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA.

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design.