List of works - Gustavo Barja

ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism

scientific article published on June 1, 1997

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

scientific article published on 14 July 2011

Calorie restriction, oxidative stress and longevity

scientific article

Correlations with longevity and body size: to correct or not correct?

scientific article published on 25 February 2014

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

scientific article published on 15 March 2015

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

scientific article published on 01 April 2007

Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain

scientific article published on 01 April 2005

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

scientific article published on 28 November 2008

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

scientific article published on 08 May 2007

Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat

scientific article published in April 2001

Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

scientific article published on 05 July 2006

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

scientific article published on 01 January 2005

Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage

scientific article published on 01 May 2006

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

scientific article

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

scientific article published on 13 May 2012

Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.

scientific article published on 22 June 2012

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

scientific article

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

scientific article published on 18 October 2011

Free radicals and aging.

scientific article published in October 2004

Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity.

scientific article published on 13 July 2007

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

scientific article published on 8 December 2013

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

scientific article

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

scientific article published in December 2000

Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain.

scientific article

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans.

scientific article published on 18 January 2008

Membrane lipid unsaturation as physiological adaptation to animal longevity.

scientific article published on 17 December 2013

Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius

scientific article published on 04 May 2020

Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro.

scientific article

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

scientific article published on 01 June 2006

Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

scientific article

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals

scientific article published on 22 January 2020

Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

scientific article

Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies.

scientific article published on June 2007

Plasma long-chain free fatty acids predict mammalian longevity.

scientific article

Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

scientific article

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

scientific article published on 4 August 2016

Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8).

scientific article published on 28 September 2015

Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction.

scientific article published on 27 February 2013

Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria

scientific article published on 01 June 2004

Testing the vicious cycle theory of mitochondrial ROS production: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondria

scientific article published on 01 April 2006

The gene cluster hypothesis of aging and longevity

scientific article published on 31 October 2007

The mitochondrial free radical theory of aging

scientific article

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

scientific article published on 6 September 2010

Towards a unified mechanistic theory of aging

scientific article published on 05 June 2019

List of works by Gustavo Barja

ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

Calorie restriction, oxidative stress and longevity

Correlations with longevity and body size: to correct or not correct?

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat

Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

Free radicals and aging.

Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity.

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain.

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans.

Membrane lipid unsaturation as physiological adaptation to animal longevity.

Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius

Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro.

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals

Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies.

Plasma long-chain free fatty acids predict mammalian longevity.

Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8).

Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction.

Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria

Testing the vicious cycle theory of mitochondrial ROS production: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondria

The gene cluster hypothesis of aging and longevity

The mitochondrial free radical theory of aging

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

Towards a unified mechanistic theory of aging