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List of works by Gilles Freyer

A Joint Model for the Kinetics of CTC Count and PSA Concentration During Treatment in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 24 April 2015

A critical review of the analytical approaches for circulating tumor biomarker kinetics during treatment

scientific article

A dynamic model of hand-and-foot syndrome in patients receiving capecitabine

scientific article published on 10 December 2008

A model of vascular tumour growth in mice combining longitudinal tumour size data with histological biomarkers

scientific article

Actionable molecular alterations in advanced gynaecologic malignancies: updated results from the ProfiLER programme

scientific article published on 24 July 2019

Adherence to oral anticancer chemotherapy: What influences patients' over or non-adherence? Analysis of the OCTO study through quantitative-qualitative methods

scientific article published on 4 July 2015

Adjuvant docetaxel/cyclophosphamide in breast cancer patients over the age of 70: results of an observational study.

scientific article published on 11 May 2011

Administration of anticancer drugs: exposure in hospital nurses.

scientific article published on 5 March 2014

Advantages of prostate-specific antigen (PSA) clearance model over simple PSA half-life computation to describe PSA decrease after prostate adenomectomy.

scientific article published on 11 April 2008

Agreement for depression diagnosis between DSM-IV-TR criteria, three validated scales, oncologist assessment, and psychiatric clinical interview in elderly patients with advanced ovarian cancer

scientific article published on 13 July 2015

Antiangiogenic therapy in patients with HER2-positive metastatic breast cancer: a case series.

scientific article

Any clinical benefit from the use of oncofoetal markers in the management of chemotherapy for patients with metastatic colorectal carcinomas?

scientific article published in May 2004

Association between immune-related adverse events and long-term survival outcomes in patients treated with immune checkpoint inhibitors

scientific article published on 22 April 2020

Avelumab in Patients With Gestational Trophoblastic Tumors With Resistance to Single-Agent Chemotherapy: Cohort A of the TROPHIMMUN Phase II Trial

scientific article published on 27 July 2020

Bevacizumab for Newly Diagnosed Ovarian Cancers: Best Candidates Among High-Risk Disease Patients (ICON-7)

scientific article published on 04 April 2020

Biology of cancer and aging: a complex association with cellular senescence.

scientific article

CA-125 ELIMination rate constant K (KELIM) Is A Marker Of Chemosensitivity In Patients With Ovarian Cancer: Results from the Phase II CHIVA trial

scientific article published on 24 March 2020

Can we predict chemo-induced hematotoxicity in elderly patients treated with pegylated liposomal doxorubicin? Results of a population-based model derived from the DOGMES phase II trial of the GINECO.

scientific article published on 3 August 2012

Capecitabine, irinotecan, oxaliplatin (CAPIRINOX) and concomitant irradiation in advanced rectal cancer: the Lyon R-02-01 phase I trial

scientific article published on 11 April 2008

Carboplatin/cyclophosphamide or carboplatin/paclitaxel in elderly patients with advanced ovarian cancer? Analysis of two consecutive trials from the Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens.

scientific article published on 2 November 2006

Celecoxib and exemestane versus placebo and exemestane in postmenopausal metastatic breast cancer patients: a double-blind phase III GINECO study.

scientific article published on 20 November 2008

Changes in the Use of Comprehensive Geriatric Assessment in Clinical Trials for Older Patients with Cancer over Time

scientific article published on 01 February 2019

Changes in the use of end points in clinical trials for elderly cancer patients over time.

scientific article

Chemotherapeutic errors in hospitalised cancer patients: attributable damage and extra costs

scientific article

Chemotherapy may be delivered based on an integrated view of tumour dynamics

scientific article published in May 2009

Clinical efficacy of the optimal biological dose in early-phase trials of anti-cancer targeted therapies

scientific article published on 31 August 2019

Combined oral topotecan plus carboplatin in relapsed or advanced cervical cancer: a GINECO phase I-II trial

scientific article published on March 1, 2012

Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study

scientific article published on 10 August 2005

Concomitant drugs with low risks of drug-drug interactions for use in oncology clinical trials

scientific article

Contribution of modelling chemotherapy-induced hematological toxicity for clinical practice

scientific article

Cross-sectional study on comorbidities and adverse events in patients with advanced and recurrent ovarian cancer in France

scientific article

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for persistent and recurrent advanced ovarian carcinoma: a multicenter, prospective study of 246 patients

scientific article published on 24 July 2012

Development of a geriatric vulnerability score in elderly patients with advanced ovarian cancer treated with first-line carboplatin: a GINECO prospective trial.

scientific article published on 22 September 2013

Dose adaptation of capecitabine based on individual prediction of limiting toxicity grade: evaluation by clinical trial simulation

scientific article published on 2 August 2011

Dynamic modeling in ovarian cancer: an original approach linking early changes in modeled longitudinal CA-125 kinetics and survival to help decisions in early drug development

scientific article published on 12 April 2014

Dénoncer et bannir

book published in 2019

EPICC study: evaluation of pharmaceutical intervention in cancer care

scientific article published on 16 January 2015

EVESOR, a model-based, multiparameter, Phase I trial to optimize the benefit/toxicity ratio of everolimus and sorafenib

scientific article published on 12 January 2017

Early Modeled Longitudinal CA-125 Kinetics and Survival of Ovarian Cancer Patients: A GINECO AGO MRC CTU Study

scientific article published on 01 April 2019

Early prediction of treatment resistance in low-risk gestational trophoblastic neoplasia using population kinetic modelling of hCG measurements.

scientific article published on 16 April 2013

Etoposide pharmacokinetics and survival in patients with small cell lung cancer: a multicentre study.

scientific article published on 28 April 2008

Etoposide pharmacokinetics impact the outcomes of lymphoma patients treated with BEAM regimen and ASCT: a multicenter study of the LYmphoma Study Association (LYSA)

scientific article published on 21 September 2015

Expectation about maintenance therapy among the GINECO French ovarian cancer cohort from the European NOGGO/ENGOT-ov22 Expression IV survey

scientific article published on 12 March 2018

Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease

scientific article

Fractionation of daily dose increases the predicted risk of severe sorafenib-induced hand-foot syndrome (HFS).

scientific article

Front-Line Maintenance Therapy in Advanced Ovarian Cancer-Current Advances and Perspectives

scientific article published on 25 August 2020

Granulocyte-colony-stimulating factor in elderly patients receiving chemotherapy for breast and gynaecological cancers: results of a French survey

article

Identification of Most Aggressive Carcinoma Among Patients Diagnosed With Prostate Cancer Using Mathematical Modeling of Prostate-Specific Antigen Increases

scientific article published on 18 December 2015

Impact of geriatric assessment for the therapeutic decision-making of breast cancer: results of a French survey. AFSOS and SOFOG collaborative work.

scientific article published on 14 December 2017

Impact of geriatric risk factors on pegylated liposomal doxorubicin tolerance and efficacy in elderly metastatic breast cancer patients: final results of the DOGMES multicentre GINECO trial.

scientific article published in June 2013

Improved Androgen Receptor Splice Variant 7 Detection Using a Highly Sensitive Assay to Predict Resistance to Abiraterone or Enzalutamide in Metastatic Prostate Cancer Patients

scientific article published on 29 October 2019

Improving cancer patient care with combined medication error reviews and morbidity and mortality conferences

scientific article published on January 2013

Inclusion of elderly patients in oncology clinical trials.

scientific article published on 29 June 2016

Influence of Dosing Schedule on Organ Exposure to Cyclosporin in Pediatric Hematopoietic Stem Cell Transplantation: Analysis with a PBPK Model ⬇️

scientific article published on September 2, 2010

Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures

scientific article published on 01 October 2003

Les enjeux de l’observance pour les nouvelles chimiothérapies par voie orale : intérêt du modèle pharmacocinétique-pharmacodynamique

scientific article published on 01 March 2007

Links Between Cyclosporin Exposure in Tissues and Graft-Versus-Host Disease in Pediatric Bone Marrow Transplantation: Analysis by a PBPK Model ⬇️

scientific article published on October 21, 2010

Long-term survival in patients with epithelial ovarian cancer following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

scientific article published on 08 October 2018

Modeling and predicting optimal treatment scheduling between the antiangiogenic drug sunitinib and irinotecan in preclinical settings

scientific article published on 11 December 2015

Multiparameter Phase I trials: a tool for model-based development of targeted agent combinations--example of EVESOR trial

scientific article published on January 2015

Non-pegylated liposomal doxorubicin (NPLD, Myocet®) + carboplatin in patients with platinum sensitive ovarian cancers: A ARCAGY-GINECO phase IB-II trial

scientific article published on 14 November 2018

Open-label uncontrolled pilot study to evaluate complementary therapy with Ruta graveolens 9c in patients with advanced cancer

scientific article

Optimal management of breast cancer in the elderly patient: current perspectives

scientific article

Oral vinorelbine: feasibility and safety profile.

scientific article published in December 2001

Over-adherence to capecitabine: a potential safety issue in breast and colorectal cancer patients

scientific article published on 15 June 2018

PD-L1 Expression in Premalignant and Malignant Trophoblasts From Gestational Trophoblastic Diseases Is Ubiquitous and Independent of Clinical Outcomes.

scientific article published on 4 January 2017

Pancreatic Neuroendocrine Carcinoma Metastatic to the Breast as Part of the Multiple Endocrine Neoplasia Type 1 Syndrome

scientific article published on 01 January 1997

Pharmacodynamic models for discrete data

scientific article

Pharmacogenetic tailoring of irinotecan-based first-line chemotherapy in metastatic colorectal cancer: results of a pilot study.

scientific article

Pharmacology of cytotoxic agents: a helpful tool for building dose adjustment guidelines in the elderly.

scientific article published on November 2003

Phase I dose-escalation study of aflibercept in combination with docetaxel and cisplatin in patients with advanced solid tumours ⬇️

scientific article published on July 12, 2012

Phase I dose-escalation study of intravenous aflibercept in combination with docetaxel in patients with advanced solid tumors.

scientific article published on 18 January 2012

Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours

scientific article

Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study.

scientific article

Prediction of tumour response induced by chemotherapy using modelling of CA-125 kinetics in recurrent ovarian cancer patients.

scientific article published on 20 February 2014

Predictive values of hCG clearance for risk of methotrexate resistance in low-risk gestational trophoblastic neoplasias.

scientific article published on 12 February 2010

Predictors of prescription errors involving anticancer chemotherapy agents

scientific article published on 28 January 2012

Prognostic factors for overall survival in elderly patients with advanced ovarian cancer treated with chemotherapy: Results of a pooled analysis of three GINECO phase II trials

scientific article published on April 2016

Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure. CPT-11 F205, F220, F221 and V222 study groups

scientific article published on August 2000

Prognostic value of modeled PSA clearance on biochemical relapse free survival after radical prostatectomy

scientific article published in September 2009

Psychosocial impact of genetic testing in familial medullary-thyroid carcinoma: a multicentric pilot-evaluation

scientific article published in January 1999

Quality of life in patients at risk of medullary thyroid carcinoma and followed by a comprehensive medical network: Trends for future evaluations ⬇️

scientific article published on October 1, 2001

Randomized Phase II Trial of Everolimus in Combination With Tamoxifen in Patients With Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer With Prior Exposure to Aromatase Inhibitors: A GINECO Study ⬇️

scientific article published on May 7, 2012

Revisiting dosing regimen using PK/PD modeling: the MODEL1 phase I/II trial of docetaxel plus epirubicin in metastatic breast cancer patients

scientific article published on 22 March 2016

Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer.

scientific article published on 02 March 2009

Routine Clinical Practice for Patients With Recurrent Ovarian Carcinoma: Results From the TROCADERO Study

scientific article published on 8 January 2016

SIMMEON-Prep study: SIMulation of Medication Errors in ONcology: prevention of antineoplastic preparation errors

scientific article published on 18 October 2014

Subcutaneous trastuzumab: development of a new formulation for treatment of HER2-positive early breast cancer

scientific article published on 14 February 2013

Successful pregnancy in a cancer patient previously cured of a gestational trophoblastic tumor by immunotherapy

scientific article published on 11 March 2020

Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase II study

scientific article published on 01 March 2003

Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: a multicenter GINECO study

scientific article

Traitement des rechutes tardives du cancer de l’ovaire

scientific article published in May 2017

Validation of an online tool for early prediction of the failure-risk in gestational trophoblastic neoplasia patients treated with methotrexate

scientific article published on 04 June 2020

[CHIP and ovarian cancer]

scientific article published on 26 June 2019

[Cytotoxic chemotherapy in elderly patients: present and future]

scientific article published on 01 July 1995

[Geriatric oncology: an emergent subspecialty]

scientific article published on 18 May 2013

[Is geriatric assessment adapted to radiotherapy?]

scientific article published on 05 October 2008

[Metastatic prostate cancer treatment in the elderly]

scientific article published on 01 July 2007

[Neurosarcoma associated with neurofibromatosis 1. Apropos of a case and review of the literature]

scientific article published on 01 March 1997

[Node negative breast cancer. Beyond international consensus: a pragmatic approach]

scientific article published on 01 July 2011

[Pharmacology of anticancer drugs in the elderly: tools for dose-adjustment]

scientific article published on 01 May 2008

[Primary peritoneal tumors: report on a series of eight cases and review of the literature]

scientific article published on 01 April 2002

[Treatment of cancer: surgery, radiotherapy, chemotherapy, hormonal therapy. Multidisciplinary therapeutic decision making and informing the patient]

scientific article published on 01 January 2003

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